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Biomedical subjects

J Kinnman

Publications and source records attributed to J Kinnman.

At least 19 recordsLinked to original sources
PubMed2000

Effect of cooling suit treatment in patients with multiple sclerosis evaluated by evoked potentials.

The aim of the present study was to determine whether any significant alterations of evoked potentials could be detected after treatment of patients with multiple sclerosis with a cooling suit. All patients had previously experienced a positive effect of this treatment. Six patients were investigated with visual, sensory and motor evoked potentials and six further patients with only motor evoked potentials. All patients had relevant clinical lesions. The mean values for the group of patients were similar before and after cooling, but a few individuals showed a substantial improvement of motor evoked potentials after cooling, with increased amplitude and/or shortened central motor conduction time. There was also a weak, but significant, correlation between temperature decrements and the reduction of central motor conduction time. However, since the central motor conduction times of most patients were only slightly affected, this effect could explain only a small part of the beneficial effect of cooling. Effects on cognition and executive ability or improvement of spasticity may be of greater importance.

Adult↗
PubMed2000

Cooling suit for multiple sclerosis: functional improvement in daily living?

Eight cryopositive patients with multiple sclerosis used cooling suits for 40 minutes regularly one or more times daily for a six-week period. The patients were given repeated motor and mental tests by a physiotherapist in order to determine whether they had a continuous beneficial effect of cooling during this period. Additionally, selected activities of daily living performed in the patient's homes were evaluated and registered according to Assessment of Motor and Process Skills (AMPS). Six out of eight patients improved in at least one motor test and all patients improved according to AMPS. For one of the patients, who was profoundly handicapped, the effect of cooling was evaluated differently.

Activities of Daily Living↗
PubMed1984

Metoprolol and propranolol in migraine prophylaxis: a double-blind multicentre study.

In a double-blind, cross-over multicentre trial, the prophylactic antimigraine effect of the beta 1-selective beta-blocker metoprolol was evaluated and compared with that of the non-selective beta-blocker propranolol. Metoprolol was used in a dosage of 50 mg b.i.d. and propranolol in 40 mg b.i.d. 56 patients with classical or common migraine were included in the double-blind part of the investigation. 3 patients withdrew, but none because of side-effects. The data suggest that metoprolol is clinically equivalent in effectiveness to propranolol in migraine prophylaxis regarding parameters such as attack frequency, improvement in sum of severity score and subjective evaluation. Both drugs were generally well tolerated and the number of reported side-effects was similar to those reported during the run-in period (placebo).

Adolescent↗
PubMed1984

Intrathecal production of oligoclonal IgM and IgG in CNS sarcoidosis.

A longitudinal study of multiple paired CSF and serum specimens from a patient with CNS sarcoidosis revealed high CSF IgM and IgG indices as well as oligoclonal IgM and IgG bands in CSF reflecting intrathecal IgM and IgG production. The antibody specificity of intrathecally-produced IgM and IgG remained undefined despite analysis for antibodies against mycobacterium tuberculosis and Kveim suspension. Steroid treatment induced rapid and complete clinical remission, and also decrease of CSF IgM and IgG antibodies, while oligoclonal IgM and IgG persisted in CSF. Repeated determinations of these CSF variables together with cell count and CSF/serum albumin ratio as a variable of blood-brain barrier function, might be useful in assessing effect of therapy in CNS sarcoidosis.

Antibody Specificity↗
PubMed1983

Sequential methotrexate-5-fluorouracil treatment of squamous cell carcinoma of the head and neck.

Thirty-six patients with squamous cell carcinoma of the head and neck were treated with sequential methotrexate-5-fluorouracil followed by leucovorin rescue. The frequency of objective tumor regression obtained was 64% (complete response + partial response) with 19% complete regression. In 20 not previously treated patients, the objective response rate was 70%. Approximately the same result was obtained for tumors of different anatomical sites of the head and neck. The degree of differentiation of the squamous cell carcinoma did not seem to be of prognostic importance for the initial tumor response. Toxicity was very mild and usually disappeared when the interval between the chemotherapy courses was prolonged from 1 to 2 weeks. Radiotherapy could be added sequentially to the treatment without measurable escalated toxicity.

Carcinoma, Squamous Cell↗
PubMed1983

Methotrexate and 5-fluorouracil in head and neck cancer.

Since experimental data strongly suggest a synergistic cytotoxic effect when methotrexate (MTX) and 5-fluorouracil (5-FU) are administered sequentially, we investigated antitumor effects and toxicity with sequential MTX/5-FU followed by leucovorin rescue in 52 patients with carcinoma of the head and neck. MTX (200 mg/m2) was given as an i.v. infusion over 1 hr. At 2 hr, 5-FU (600 mg/m2) was started as an i.v. infusion for 2 hr. At 24 hr, the leucovorin rescue was started. The chemotherapy course was repeated every week until toxicity (mainly gastrointestinal) occurred, after which the interval between courses was prolonged to 2 wk. Toxicity was mild and usually disappeared when the interval between the chemotherapy courses was prolonged to 2 wk. The regression rate was 15% for complete and 48% for partial regression (response rate, 63%). In 31 of the patients not previously treated, the objective response rate was 74%. About the same results were obtained for tumors of different anatomic sites of the head and neck. Radiotherapy could be added sequentially without measurable escalation of toxicity. We conclude that sequential MTX/5-FU treatment, which produces a very mild toxicity to normal tissue, is effective in inducing antitumor response in patients with carcinoma of the head and neck.

Carcinoma, Squamous Cell↗
PubMed1981

Tuberculous meningitis: immune reactions within the central nervous system.

Cerebrospinal fluid (CSF) lymphocytes from two patients with tuberculous meningitis proliferated stronger than the corresponding peripheral blood lymphocytes (PBL) when stimulated with tuberculin purified protein derivative (PPD) in the lymphocyte transformation test after 3 days of culture. This might indicate an accumulation of specifically primed lymphocytes within the central nervous system. CSF lymphocytes and PBL from nine of ten patients with acute aseptic meningitis investigated as controls showed no or low responses when stimulated with PPD, whereas the remaining patient displayed a significant proliferation of CSF lymphocytes, which was more pronounced than that of PBL. Stimulation with the mitogens phytohaemagglutinin, concanavalin A, and pokeweek mitogen gave lower proliferation of CSF lymphocytes compared with PBL in tuberculous and aseptic meningitis. Evaluation of the proliferative response of CSF lymphocytes compared with PBL on stimulation with PPD might be a useful complement in the diagnosis of tuberculous meningitis.

Adolescent↗
PubMed1981

Characterization of antibody activity in oligoclonal immunoglobulin G synthesized within the central nervous system in a patient with tuberculous meningitis.

Thin-layer polyacrylamide gel isoelectric focusing of cerebrospinal fluid (CSF) and serum obtained from one patient 48 and 65 days after the onset of tuberculous meningitis revealed five oligoclonal immunoglobulin zones in CSF without any counterpart in serum, indicating local immunoglobulin production. Subsequent immunofixation with specific antisera revealed that three of the zones consisted of immunoglobulin G lambda present simultaneously. Immunofixation with Mycobacterium tuberculosis and bacillus Calmette-Guérin (BCG) as antigens and autoradiography revealed zones of specific antibodies in the CSF which, regarding mobility, corresponded to oligoclonal and polyclonal CSF immunoglobulin G zones. No antibody activity was detectable in the corresponding serum, indicating that the antibodies present in CSF were synthesized within the central nervous system. In seven control patients (three with multiple sclerosis, four with chronic inflammatory central nervous system diseases of unknown cause) with oligoclonal CSF immunoglobulin, no evidence for local production of antibodies against M. tuberculosis or BCG was detectable. Immunofixation with M. tuberculosis or BCG as antigens and autoradiography may prove to be a useful diagnostic complement to conventional techniques in patients with suspected tuberculous meningitis.

Adult↗
PubMed1981

Treatment of carcinoma of the head and neck with combined irradiation and chemotherapy.

Radiation therapy was combined with simultaneous administration of bleomycin, cyclophosphamide and 5-fluorouracil for the treatment of 33 patients with carcinoma of the head and neck. This combination increased the toxicity to the normal tissue. Complete response was obtained in 46 per cent, partial response in 36 per cent and no response in 18 per cent. Patients with a complete response had a significantly longer survival than patients with a partial or no response. An increased cytotoxicity was noted after the combined treatment when compared with irradiation alone. However, no evidence of an increased therapeutic effect was obtained with the addition of simultaneous chemotherapy to irradiation.

Bleomycin↗
PubMed1979

Studies on the humoral and cell-mediated immune response in a patient with Mollaret's meningitis.

A patient with Mollaret's meningitis with protracted course and a strong immune response within the central nervous system is described. The findings of IgG bands in agarose gel electrophoresis of CSF together with elevated CSF IgG index values are in accordance with intrathecal synthesis of IgG, possibly against an antigen persistent in the CNS. Subgrouping of CSF lymphocytes morphologically (B/T, active T cells) and functionally (stimulation with mitogens) showed that these cells differed from peripheral blood lymphocytes. A defect in the regulatory function of T cells may be responsible for the continuing pathologic process in Mollaret's meningitis.

Antibodies, Viral↗
PubMed1979

Measles-adherent lymphocyte phenomenon of Levy in multiple sclerosis: normal reactivity of blood lymphocytes.

The measles-adherent phenomenon described by Levy in multiple sclerosis was investigated by studying the rosetting effect of blood lymphocytes from multiple sclerosis patients and healthy controls on chronically measles infected heteroploid Hela cells (Lu 106). No significant difference in rosetting was observed, irrespective if a lymphocyte/virus infected Lu cell ratio of 10/1 or 50/1 was used. Therefore, the test is not discriminative for multiple sclerosis.

Adult↗
PubMed1979

Normal functional capacity of blood lymphocytes in multiple sclerosis measured by stimulation with mitogens.

The effect of phytohemagglutinin (PHA) and pokeweed mitogen (PWM) on blood lymphocytes was studied in multiple sclerosis, patients with acute CNS infections, and healthy controls. No significant differences in lymphocyte proliferation were registered between the group of MS patients and the two other groups, irrespective of mitogen used. The ratio between the PWM and PHA responses did not differ significantly from the ratios in the two other groups. The lymphocyte proliferation with PWM was significantly lower in the group with acute CNS infections compared with controls. The results indicate that alterations in cell-mediated immunity, if present in MS, are not confined to lymphocytes outside the CNS.

Adult↗
PubMed1978

Influence of measles virus antigen on leukocyte migration in multiple sclerosis and controls.

The leukocyte migration inhibiton test was used in multiple sclerosis patients and in healthy controls for investigation of sensitization of blood lymphocytes against preparations of measles virus, mumps, NDV virus, and PPD. Regardless of antigen used, no significant differences were found between the groups. There was a strong correlation between the leukocyte migration inhibition obtained with measles virus antigen and with PPD. The leukocytes from MS patients as well as from healthy controls showed a significantly more pronounced inhibiton when a Tween 80 and ether-treated preparation of measles virus was used, compared with the whole measles virus antigen. No correlations were found between the degree of leukocyte migration inhibition and the antibody titers against different components of measles virus in individual samples.

Adult↗