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Biomedical subjects

J Kirpensteijn

Publications and source records attributed to J Kirpensteijn.

At least 19 recordsLinked to original sources
PubMed2002

Prognostic significance of a new histologic grading system for canine osteosarcoma.

Histologic grade is an important determinant in clinical outcome of human osteosarcoma (OS). In this study, the histologic characteristics of primary and metastatic canine OS were evaluated using a new classification system. Histologic characteristics were classified in 166 primary and 34 metastatic canine OS. Prognostic variables for clinical outcome were determined using multivariate analysis. Most OS were histologically characterized by severe to extreme cellular pleomorphism, a variable number of mitoses, small to moderate amounts of matrix, a high percentage of tumor cells, and minimal to moderate amounts of necrosis. Tumor invasion into vessels was present in 117/152 (71%) tumors, and 12/50 (24%) of the regional lymph nodes had evidence of metastasis. Classification of the 166 tumors resulted in seven (4%) grade 1, 34 (21%) grade II, and 125 (75%) grade III OS. In the multivariate analysis, histologic grade III OS and elevated pretreatment plasma alkaline phosphatase (AP) levels were independent predictors of clinical outcome. Dogs with high-grade tumors and elevated AP should be carefully evaluated for the presence of metastatic disease before starting adjunctive therapy protocols.

Animals↗
PubMed2001

[Signs of estrus in an ovariectomized ferret].

Signs of oestrus, including vulvar swelling and alopecia are frequently seen in ovariectomized ferrets. Between 1997 and 1999, 25 ovariectomized ferrets presented with symptoms of vulvar swelling and symmetric alopecia at the University Clinic of Companion Animals. In 18 of these animals, ovarian remnants were found. To prevent failure to remove all ovarian tissue in the ferret, thorough identification of the ovaries, which are surrounded by large fat deposits, is necessary. The incision should be long enough to allow good visualization of the surgical field.

Alopecia↗
PubMed2001

Comparison of three closure methods and two absorbable suture materials for closure of jejunal enterotomy incisions in healthy dogs.

The macroscopic and histological appearance of jejunal antimesenteric incisions approximated with two different absorbable suture materials (monofilament versus multifilament) and three closure techniques (appositional single layer, crushing single layer, and double layer) were compared in healthy dogs at 14 or 28 days, postoperatively. No significant differences between the two suture materials were observed for most of the macroscopic or histological variables. However, the monofilament suture material caused significantly more fibrous tissue reaction in the muscular layer of the jejunum than did the multifilament suture material. Of the three enterotomy closure techniques used in this study, the appositional single-layer method proved to be the best. The double-layer closure method caused a significant decrease in the incisional circumference, the relative circumference, and volume of the jejunum, and a significant increase in jejunal wall thickness. Our findings suggest that canine jejunal enterotomy incisions can be closed using an appositional suture pattern with relatively rapidly absorbable monofilament suture material. The use of double-layer suture patterns for closure of jejunal enterotomy incisions should be avoided because the size of the intestinal lumen may be reduced.

Absorption↗
PubMed2001

Hepatic arteriovenous fistulae and portal vein hypoplasia in a Labrador retriever.

An 18-month-old male Labrador retriever was referred for investigation of chronic intermittent diarrhoea and vomiting of two months duration. A diagnosis of hepatic arteriovenous fistulae was made. These are extremely rare hepatic vascular anomalies which confer arterial pressure to the portal vein. Liver atrophy, portal vein hypoplasia, portal hypertension and multiple acquired portosystemic collateral vessels are the main complications. Surgical excision is a challenge as resection of large lesions may be associated with significant blood loss. In this dog, persistence of portal vein hypoplasia and extensive collateral pathways following surgery led to a reserved prognosis.

Angiography↗
PubMed2000

Ground reaction force analysis of large breed dogs when walking after the amputation of a limb.

Force plate analysis was used to measure ground reaction forces (GRF) and contact times, and calculate the centre of gravity at a walk of 10 dogs which had had a limb amputated, and the results were compared with the results from 22 normal dogs of the same weight. The loss of a limb caused significant changes in the GRF, impulses and contact times of the remaining limbs and in the location of the dogs' centre of gravity. The changes were greater in dogs which had lost a forelimb than in dogs which had lost a hindlimb.

Amputation, Surgical↗
PubMed1999

Adaptation of dogs to the amputation of a limb and their owners' satisfaction with the procedure.

Forty-four Dutch dog owners were interviewed by telephone about their experiences with their dog after it had had a limb amputated. Most of the dogs adapted to walking on three legs within a month, sooner than most of the owners had expected. There were few complications after the amputation, although changes in behaviour were observed in approximately one-third of the dogs.

Adaptation, Physiological↗
PubMed1997

[Tumor surgery].

Companion animals reach an older age because of advances in veterinary medicine. Pets with cancer are an important group of patients that are frequently presented to the general practitioner for diagnosis and treatment. In order to fulfill these demands it is essential to have basic knowledge about cancer and its treatment. The surgeon plays an important role in the treatment of companion animals with oncologic diseases. Surgery is one of the most successful treatment options for many tumor types. A radical surgery after an accurate diagnosis results in the best chance for a total cure. The goal of this article is to review the important principles of oncologic surgery. Topics such as biopsy techniques, and oncologic surgery techniques will be discussed.

Animals↗
PubMed1997

Influence of orchiectomy on canine behaviour.

One hundred and twenty-two dog owners were interviewed to obtain information about the effects of orchiectomy on the behaviour, unwanted side effects, and testosterone-dependent disease processes in their dogs. Behavioural problems were the main reason for orchiectomy, unwanted sexual behaviour being the most common, together with roaming, aggression, and abnormal urination behaviour. Objectionable sexual behaviour, inter-male aggression, roaming, and abnormalurination were reduced after orchiectomy in approximately 60 per cent of the dogs. The side effects of orchiectomy included increased bodyweight, increased appetite and decreased activity in less than 50 per cent of the dogs, and there was a significant relationship between increased appetite and bodyweight. The clinical signs of testosterone-dependent disease in most of the dogs either decreased or disappeared after orchiectomy.

Aggression↗
PubMed1997

P53 gene mutations in osteosarcomas in the dog.

Osteosarcomas in 18 dogs were examined for the presence of p53 mutations in exons 4-8 by single strand conformation polymorphism (SSCP) analysis, followed by sequence analysis in tumors demonstrating abnormal bands in the SSCP analysis. P53 mutations were found in four of the primary tumors in 17 dogs. Metastases studied in two of these dogs in which the primary tumor contained only wild type p53 did not contain mutations, nor those of one dog in which the primary tumor was not studied. The alterations that were found included three missense mutations and one 3 bp insertion.

Animals↗
PubMed1997

Comparison of two suture materials for intradermal skin closure in dogs.

The macroscopic and histological appearance of cutaneous incisions closed with polyglecaprone 25 (Monocryl) and polyglactin 910 (Vicryl) suture materials were compared in four dogs. Polyglecaprone 25 compared favourably to polyglactin 910 suture material for closure of canine skin incisions, and was associated with significantly less tissue reaction in the early phases of the healing process than was polyglactin 910 suture material. This difference was not present at later evaluation times.

Animals↗
PubMed1997

Lack of association of progestin-induced cystic endometrial hyperplasia with GH gene expression in the canine uterus.

Growth hormone (GH) is produced in progestin-induced hyperplastic ductular mammary epithelia in dogs. Progestins also induce the development of cystic endometrial hyperplasia (CEH) in this species. The study reported here investigated whether GH gene expression could also be demonstrated in progestin-induced hyperplastic epithelium in the canine uterus. Eight beagle bitches were treated with 10 mg medroxyprogesterone acetate (MPA) kg-1 body mass s.c. at intervals of 3 weeks, for a total of five times in four dogs (group I) and for a total of 13 times in the other four dogs (group II). Blood samples were collected twice during each 3 week period for measurement of plasma concentrations of GH, insulin-like growth factor I (IGF-I) and IGF-II. At the end of the series of injections uterine tissue was obtained by ovario-hysterectomy. Histological examination confirmed that CEH was present in all uteri after MPA treatment; the changes in the dogs of group I were less marked than those in group II. Immunohistochemical examination of the uterine tissues showed that immunoreactive(i) GH was present in a number of uteri with CEH. iGH was usually located in the cytoplasm of glandular epithelial cells. However, reverse transcriptase PCR using GH-specific primers failed to demonstrate mRNA encoding GH in the uterine tissue of all dogs. It is concluded that local production of GH is not involved in progestin-induced hyperplasia of uterine epithelial cells in dogs.

Animals↗
PubMed1995

Oncologic surgical emergencies.

Surgical oncologic emergencies are relatively common and pose a clinical and therapeutic challenge for the emergency clinician. This article provides a clear clinical reference for assessment and management of some common surgical emergencies in cancer patients.

Animals↗