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Biomedical subjects

J Kjaergård

Publications and source records attributed to J Kjaergård.

4 recordsLinked to original sources
PubMed1995

Cimetidine as an adjuvant treatment in colorectal cancer. A double-blind, randomized pilot study.

PURPOSE: To evaluate the influence of a H2 receptor antagonist (cimetidine) on survival in patients with colorectal carcinoma, a randomized, controlled pilot study was performed in three university hospitals in Copenhagen, Denmark. METHODS: A total of 192 patients, who had undergone a resection or an exploratory operation for adenocarcinoma of the colon or rectum between May 1988 and May 1991, were enrolled in the study. After a median observation time of 40 months, outcome was noted for each patient concerning cancer-specific mortality rate. RESULTS: In patients operated with curative intent (n = 148), no difference was found in cancer-specific mortality between the two treatments. However, a tendency toward reduction in mortality rate was found in patients with curatively operated Dukes Stage C carcinoma (P = 0.11, log-rank test; difference, 29 percent; 90 percent confidence interval, 2 to 57 percent) in the cimetidine-treated group. In patients with disseminated disease no total difference was found between the two treatment groups. CONCLUSIONS: Cimetidine does not seem to reduce mortality in patients with colorectal cancer, but there seems to be a tendency toward a survival benefit in patients undergoing surgery for Dukes Stage C carcinoma. Results seem to justify trials in this patient category to reveal a benefit of H2 receptor antagonists in adjuvant therapy of colorectal carcinoma.

Adenocarcinoma↗
PubMed1991

Fibrin adhesive in the treatment of perineal fistulas.

Fifteen patients who developed a persistent perineal sinus after excision of the rectum and eight patients with a perineal fistula appearing after treatment of perineal abscesses were treated with instillation of fibrin adhesive to close the sinus or fistula. In 12 patients, the sinus tracts or fistulas were completely and permanently closed (52 percent). In five patients (22 percent), the fistulas healed after two or three attempts, while, in six patients (26 percent), the method failed to provide lasting closure. The method seems to be a valuable alternative in the treatment of a persistent, long and narrow perineal sinus or fistula.

Administration, Topical↗
PubMed1986

Subcutaneously implanted injection system for epidural administration.

Six patients with advanced disseminated cancer were treated by operatively implanting a subcutaneous injection system for epidural opiate injection. The system consisted of an access port connected to an epidural catheter. The median period of treatment during hospitalization was 16 days (9-64). Two discharged patients were treated for 9 and 150 days, respectively. The median number of injections was 92 (48-542). Patient compliance was good in all cases. There was no case of displacement, kinking or occlusion of the catheters. All patients experienced sufficient pain relief, although four, before epidural opiate treatment, had their pain triggered by activity.

Humans↗