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Biomedical subjects

J Kleinheinz

Publications and source records attributed to J Kleinheinz.

At least 19 recordsLinked to original sources
PubMed2006

Free vascularized fibular grafting for reconstruction after tumor resection in the upper extremity.

BACKGROUND: Limb salvage is viable in the majority of patients with malignant bone tumors, but especially in case of extensive tumors and bad soft tissue conditions, it is challenging in upper extremity. OBJECTIVES/METHOD: The clinical and radiological results of 21 patients, who had free vascularized fibular grafts (VFG), for diaphyseal (14), and epipyseal (7) defect reconstruction of the upper extremity, are presented. The indications for VFG were resection after osteosarcoma (9 cases), Ewings sarcoma (9 cases), chondrosarcoma (1 case), rhabdomyosarcoma (1 case), and 1 case of fibrous dysplasia. The 20 malignant tumors were staged as follows: 2a (1), 2b (18), 3 (1). The mean follow-up was 43.6 months (min 6.0-max 131.9). Functional results were described and graded quantitatively according to the MSTS-score. RESULTS: Results were satisfactory with regard to pain, emotional acceptance, manual dexterity, and function. Lifting ability was decreased in two patients. Hypertrophy index was 31% (min 13%-max 71%). Main complications were fracture (5), pseudoarthrosis (4), prolonged wound healing (4), temporary nerve irritation (2), and deep infection (1). Re-operation was required in eight patients (12 operations). CONCLUSION: VFG offers a good possibility for biological reconstruction of large skeletal defects, with an acceptable complication and re-operation rate. When conservative treatment of complications was not successful, further surgery led to recovery in the majority of cases.

Adolescent↗
PubMed2005

[Aggressive fibromatosis in the jaw and facial region with bone involvement. A review].

BACKGROUND: Aggressive fibromatosis (AF) involving bones of the head is rare and surgery is often complicated by a high recurrence rate. Interdisciplinary treatment is of the utmost importance to avoid extensive, mutilating resection. Two cases emphasize the difficulties in the management. CASE REPORTS: A 67-year-old woman was referred to our unit with a blepharochalasis of the left upper palpebra and a palsy of the face on the left side. Her medical history included 12 operations over the previous 4 years for an extensive AF. MATERIAL AND METHODS: Our review includes all case reports of AF involving bones of the head published between 1960 and 2004. Additionally, our two cases are presented. Signs, symptoms and outcome were analyzed in relation to different treatment options. CONCLUSION: According to the literature, surgery is the most common treatment for AF in the head and neck region. Alternative modes of therapy must be considered because of the high recurrence rate and to avoid mutilating operations.

Aged↗
PubMed2005

Score system for elective tracheotomy in major head and neck tumour surgery.

BACKGROUND: This study was designed to evaluate prognostic parameters for respiratory failure after major oropharyngeal resections in head and neck cancer surgery, focusing on a score system to identify patients requiring an elective tracheotomy and to avoid tracheotomy under emergency conditions. METHODS: One hundred and fifty-two out of 928 patients with oropharyngeal cancers, treated between January 1993 and June 2000 at our hospital, fulfilled the inclusion criteria for a retrospective analysis. This collective underwent tumour resection in different regions of the oropharynx combined with bony resection of the mandible and neck dissection without primary tracheotomy. The reconstruction was accomplished using radial forearm flaps (n1 = 59) or local flaps (n2 = 93). These two groups were subdivided into patients treated post-operatively by tracheotomy due to respiratory failure (n1 = 26; n2 = 12) and those without such treatment (n1 = 33; n2 = 81). The database comprising tumour localization and size, staging, general medical condition, smoking and alcohol consumption was evaluated by logistic regression. RESULTS: We developed a score system which predicts the likelihood of post-operative respiratory failure. For indication of tracheotomy, tumour size and localization, multimorbidity, alcohol consumption and pathologic chest X-ray findings were identified as significant parameters with different weightings. The predictive value for tracheotomy (yes/no) using the score system was 96.7% for the total collective. CONCLUSION: The decision on whether or not an elective tracheotomy in major head and neck tumour surgery is necessary can be facilitated using this score system which is based on objective facts. It may reduce post-operative complications and contribute to safer treatment.

Adult↗
PubMed2004

[Peri-implant bone formation around cylindrical and conical implant systems].

BACKGROUND: The treatment of patients with early or immediately loaded dental implants has renewed interest in the behavior of osseointegration at the implant surface. Whereas it is generally accepted that peri-implant tissue formation and mineralization are dependent on the local mechanical environment in the interface zone, controversies exist concerning the impact of implant design on peri-implant bone formation. The aim of the present study was the in vivo evaluation of peri-implant bone formation by two different implant systems: cylindrical (ITI) versus conical (ILI). MATERIAL AND METHOD: A total of 60 implants (30 ITI and 30 ILI) were placed in the cranial and caudal part of the tibia of eight Göttinger minipigs. Half of the minipigs were sacrificed at 7 days and 28 days of osseointegration. Implant-containing bone specimens were prepared for histological and ultrastructural investigations. RESULTS: Histological and scanning electron-microscopic investigations showed a direct contact of bone-like minerals over the whole implant surface from day 7 of implant/bone interaction. Whereas the ILI implant showed direct contact up to the top of the crestal bone, ITI implants demonstrated a crestally located narrow gap without ossification over the whole experimental period. CONCLUSION: Our investigations support the hypothesis of an implant design-inherent emergence and maintenance of crestal bone.

Animals↗
PubMed2003

[Primary implant stability with different bone surgery techniques. An in vitro study of the mandible of the minipig].

The treatment concept of osseointegration is based on a stable embodiment of implants in bone and the maintenance of stability during functional load. A goal of the surgical preparation technique is therefore to obtain a stable and firm implant anchorage. The aim of this study was to evaluate implant stability after different surgical treatment of the bony implantation bed. Thirty cylindrical solid-screw-shaped implants with standard SLA ITI configuration were implanted into the explanted mandibles of five minipigs. The implant sites were prepared either by a conventional burr technique (group A), by burr technique with additional thread cutting (group B), or by the osteotome technique (group C). Primary implant stability was evaluated by resonance frequency analysis and removal torque test. The average value of the resonance frequency analysis (RFA) was 6000+/-469 cycles/s in group A, 5700+/-557 cycles/s in group B, and 5540+/-527 cycles/s in group C. Removal torque values of group A (507+/-57 Nmm) were significantly higher than those of group B (466+/-45 Nmm) and group C (240+/-31 Nmm) (between group A and C p<0.05, group A to B p=0.39, and B to C p<0.05). It can be concluded from this study that the conventional burr technique achieves a statistically significantly better primary bone anchorage than the osteotome technique.

Animals↗
PubMed2003

[Odontogenic foci--possible etiology of urticaria?].

Recent studies have shown that chronic odontogenic infections could pose a risk for myocardial infarction, cerebral ischemia, and arteriosclerosis. However, the correlation between urticaria and dental infections has rarely been examined so far. Therefore, we performed a case-control study using a standardized questionnaire and examination. We investigated 66 patients suffering from an acute or chronic urticaria and 65 age- and sex-matched healthy patients as a control group. Dental status was determined by a so-called total dental index (TDI) which primarily reflects caries, periodontitis, periapical lesions, and nonvital and missing teeth. All 66 patients were referred from the department of dermatology. After their treatment in hospital, all patients received a questionnaire with questions on intensity and localization of the urticaria. The TDI of the urticaria patients was slightly better ( n=66; 2.6+/-1.98) than that of the control group ( n=65, TDI=3.3+/-1.86). Subsequently, it was determined if the urticaria had receded after dental treatment. In conclusion, chronic dental infections do not seem to correlate with an increased risk for urticaria.

Adult↗
PubMed2002

[Evaluating angiogenesis and osteogenesis modified by vascular endothelial growth factor (VEGF)].

PURPOSE: This intention of this study was to investigate the influence of controlled release of vascular endothelial growth factor (VEGF) on angiogenesis and osteogenesis in a mandibular defect model. METHODS: A total of 56 rabbits were operated and bicortical holes were placed in the mandible. The defects were filled with collagen type I implants, collagen implants complexed with 0.8-microgram VEGF165, or left without any filling. After 3, 7, 14, and 28 days specimens were taken and histologic, histomorphometric, and immunohistologic analyses were carried out concerning density of vessels, total surface of vessels, bone surface, and bone density. RESULTS: The number of vessels was increased in all groups up to 14 days, followed by physiologic regression in the control groups, whereas the study group showed persistently high numbers. The density of regenerated bone was significantly higher in the study group. CONCLUSION: The activation of angiogenesis using VEGF165 leads to more intensive angiogenesis and bone regeneration.

Animals↗
PubMed2002

Salivary levels of vascular endothelial growth factor (VEGF) in recurrent aphthous ulceration.

BACKGROUND: Vascular endothelial growth factor (VEGF) is a multifunctional angiogenic cytokine involved in angiogenesis and wound healing. Its presence in recurrent aphthous ulceration has not been reported to date. The aim of this study was to investigate the association of salivary levels of VEGF with various stages of recurrent aphthous ulceration (RAU). METHODS: VEGF levels were determined in a group of 27 age and sex-matched healthy controls and in 30 patients with minor and major RAU grouped into the three stages: (I) early active stage, (II) active stage, and (III) remission period. VEGF levels (pg/ml; mean +/- SD) in unstimulated whole saliva were determined by enzyme immunoassay. RESULTS: Patients with major RAU - stages I and II - had decreased VEGF values (765 +/- 458 and 341 +/- 109, respectively) when compared both to healthy controls (1652 +/- 567; P < 0.01) and to stage III major RAU (1524 +/- 784; P < 0.005). CONCLUSION: Salivary VEGF levels seemed to be associated with ulcer development in major RAU, showing stage-dependent alterations during the course of this disorder.

Adult↗
PubMed2001

Natural immunity in recurrent aphthous ulceration.

In the present study we investigated immunophenotypes of peripheral blood lymphocytes, natural killer (NK) cell activity as well as spontaneous migration, ingestion, digestion and antibody-dependent cell-mediated cytotoxicity (ADCC) as effector functions of polymorphonuclear neutrophil granulocytes (PMNs) in 51 patients with acute stage recurrent aphthous ulceration (RAU), during remission, and 47 age-matched healthy individuals. Statistically significant lower B-lymphocyte (CD19) values were found between patients with acute RAU, and those during the remission period (P<0.001), when compared with those of the controls. Total T-lymphocyte (CD3) percentages were lower in patients with RAU, and also during the remission period, when compared with the controls (P<0.001). The percentages of CD4 lymphocytes were significantly lower in patients with RAU in comparison with those of the controls (P<0.001). T-suppressor cells (CD8) were unchanged in all three groups of participants. Significantly lower spontaneous migration and ingestion values were found in patients with acute RAU, when compared with those of the controls, and during the remission period (P<0.001). Digestion values differed insignificantly between the patients with acute RAU and during the remission period. During the remission period, digestion values were significantly elevated when compared with those of the controls (P<0.05). ADCC values were lower during the remission period (P<0.001), when compared with the values during acute RAU and with those of the controls. Significantly depressed NK activity (P<0.001) was observed in patients with acute RAU, when compared with that of the controls. During the remission period, values of NK activity were also lower (P<0.001) when compared with those of the controls. These results suggest either a specific or nonspecific immunological disorder in patients with RAU.

Adolescent↗
PubMed2001

Imaging of cartilage and mimic muscles with MRI: anatomic study in healthy volunteers and patients with unilateral cleft lip and palate.

OBJECTIVE: The aim of the study was to visualize different soft tissues in the perioral, nasal, and paranasal region by means of magnetic resonance imaging (MRI) in patients with unilateral cleft lip and palate (UCLP). DESIGN: In this descriptive study, images of different MRI systems were assessed and compared. METHOD: MRI was applied in five consecutive patients operated on for UCLP who underwent secondary lip and nasal correction, two patients who had not had UCLP operations, and five healthy volunteers as controls. The mimic muscles, vessels, and nasal cartilages were evaluated. RESULTS: It was possible to visualize different parts of the paranasal and perioral mimic muscles and their interlacement in the upper lip. The nasal cartilages were also visible, and the changes after operation were demonstrated. CONCLUSIONS: MRI shows differentiated visualization of soft tissues in the cleft region and their changes after surgery. It is a valuable tool in the preoperative planning and postoperative follow-up in patients with UCLP.

Adolescent↗
PubMed2000

[Prospective cephalometric evaluation of a new 3-dimensional adjustable osteosynthesis system for sagittal ramus osteotomy].

The aim of the study was the prospective cephalometric analysis of 58 patients who underwent sagittal split ramus osteotomy (SSRO). Stabilisation of the fragments was achieved with an adjustable monocortical bone fixation system. Lateral cephalograms were taken preoperatively, postoperatively, 6 months postoperatively, and 12 months postoperatively. The radiographs were digitised, and a computerised analysis was performed. The mean mandibular advancement was 8.5 mm with a mean relapse of 0.8 mm after 12 months (P < 0.05). The mean mandibular setback was 7.8 mm with a mean relapse of 1.2 mm after 12 months (P < 0.05). The results of the present study show a minimal relapse after mandibular advancement and setback for the SSRO and the new adjustable fixation system. Postoperative analysis reveals a safe intraoperative positioning of the condyles with subsequent prevention of an immediate relapse. The results after 12 months indicate sufficient long-term stability, although additional evaluations with results after 5 and 10 years are necessary for a final report.

Adolescent↗
PubMed2000

[Effect of implant geometry on strain distribution in peri-implant bone].

Recent developments and results in the field of mechanical bone stimulation have made it possible to define limits between physiological and non-physiological transmission of strength to the bone. Now it is necessary to investigate the different geometries of dental implants regarding biomechanical reliability. The aim of this study was to examine the distribution of strain on the bone along different basic forms of implants during loading using finite element analysis (FEA). The following implant designs were included in the study: cylinder, threaded cylinder, cylinder with steps, threaded cylinder with steps, and double-disk implants. All implants had a length of 12 mm and a diameter of 4 mm, the axial loading was defined as 300 N. Threaded implants showed more homogeneous distribution of strain than stepped implants, however, the maximum values were below the physiological range. Shortening of the implants led to an increase of the values, however, there was a zone of hypophysiological strain apically. Disk implants showed extremely low values at the disk margins, possibly due to the lack of physiological bone stimulus by the disks. Overall, none of the implants showed optimal distribution of strain, even though homogeneous strain distribution is decisive for long-term implant stability.

Alveolar Process↗
PubMed2000

Clinical anatomy and palpability of the inferior lateral pterygoid muscle.

STATEMENT OF PROBLEM: The intraoral palpation technique of the inferior belly of the inferior lateral pterygoid (ILP) muscle is a standard diagnostic examination method for temporomandibular joint dysfunction syndrome, although different studies have revealed inconsistent results. PURPOSE: This study assessed the feasibility of the ILP muscle palpation by a simulated clinical setting. MATERIAL AND METHODS: Three dentists performed a bilateral palpation of the ILP muscle in 53 fresh and unfixed human cadavers and decided whether the muscle was palpable or unpalpable. In a second step, it was observed through the dissected infratemporal fossa, whether the examiner's finger did or did not touch the ILP muscle by simulating the performed palpation. Palpatory findings were supplemented by 1-dimensional measurements for determination of topographic relations of the ILP muscle within the infratemporal fossa. For statistical analysis, sensitivity, specificity, and negative and positive predictive values of the palpation technique were calculated. Interexaminer agreement was estimated with the kappa value. RESULTS: In 86 of 106 dissected specimens, a superficial fascicle of the medial pterygoid muscle was found in direct proximity to the ILP muscle. In these cases, a residual distance of 7.8 +/- 3.2 mm remained between the ILP muscle and buccinator fascia indented by the tip of the examiner's finger. In 10 of 20 specimens with an absent superficial fascicle, the finger was able to reach the ILP muscle. CONCLUSION: It is recommended that the ILP muscle palpation technique should no longer be considered as a standard clinical procedure because it is nearly impossible to palpate the ILP muscle anatomically and because the risk of false-positive findings (by palpation of the medial pterygoid muscle) is high.

Facial Pain↗
PubMed2000

Oral findings in three different groups of immunocompromised patients.

The objective of this study was to determine the frequency of oral, dental and periodontal findings in three different groups of immunocompromised patients and in a healthy control group, to evaluate whether there is a correlation between manifestations of disease and immunologic parameters. The survey included 46 patients with a diagnosis of systemic lupus erythematosus, 48 heart transplant recipients, and 53 adult patients suffering from acute leukemias. Fifty matched healthy subjects were used as a control group. Each patient had to answer questions on medical and dental health and underwent a thorough oral, dental and serological investigation. Oral mucosal lesions were found in nearly half of all immunocompromised patients (49.6%), but in only 26% of control patients. No significant associations were found between different types of oral lesions and the underlying cause of immunosuppression. Leukemia patients showed age-unrelated higher scores in periodontal indices (P<0.05). Laboratory parameters failed to be significant in the assessment of oral health.

Adult↗
PubMed2000

Reconstruction of the severely resorbed (Class VI) jaws: routine or exception?

After disappointing results with conventional preprosthetic procedures endosseous implants in combination with alveolar ridge augmentation opened up new prospects in reconstructive surgery. A total of 64 patients who underwent three-dimensional reconstruction of the alveolar ridge and insertion of endosseous implants for severe resorption were evaluated retrospectively. Despite the postoperative infection rate of 20.3% (13 patients), only 4.1% of the 266 inserted implants were lost in the long term. This indicates that augmentation using free autogenous iliac bone grafts and implants have a success rate of approximately 96% despite difficult initial situations. This success was mainly related to the soft tissue condition covering the graft. A technique for soft tissue dissection, especially in the maxilla, is presented.

Adult↗
PubMed2000

Three-dimensional magnetic resonance imaging of the orbit in craniofacial malformations and trauma.

Craniofacial malformations and trauma often lead to changes in orbital soft tissues, requiring surgical correction of both hard and soft tissues. Computed tomographic scans and 3-dimensional reconstructions are the optimal tools for evaluation of the bony structures. However, there is no equivalent method for the orbital soft tissues. The aim of this study was to establish a 3-dimensional magnetic resonance imaging (3-D MRI) technique that allows a differentiated visualization of the different types of soft tissue in the orbit. A total of 8 patients with different pathologic conditions of the orbit was examined. Five of these patients underwent secondary correction after trauma, and 3 had craniofacial malformations. The 3-D reconstruction was performed in the volume-rendering technique after acquisition of 3-mm axial slices. It was shown that a differentiated visualization of the orbital soft tissues is possible. Although the thin bony structures have a weak signal and, therefore, the imaging is poor, reliable reconstruction of the globe was achieved by different radiologists because of its circular delimitation from the bone. This technique is an additional support in the planning of orbital surgery.

Craniofacial Abnormalities↗
PubMed1999

[Regeneration of mouth mucosa in the buccal plane following graft procurement for reconstruction of bulbar urethral stenoses].

The use of free buccal mucosal grafts in the treatment of urethral strictures has become very popular. In 1996 and 1997 we harvested free buccal mucosal grafts up to 7 cm long and 4 cm wide from 12 patients who underwent urologic surgery for urethral strictures. In 2 patients the donor site was closed primarily by sutures. Four patients received Lyodura and another 4 patients received Syspurderm as temporary wound coverage. In 2 patients Ethisorp patches were used. Donor site pain was judged by the patients on a visual analogue scale during the first postoperative week. The 2 patients who received the Ethisorp patches complained of more intense pain, probably caused by the rigidity of the material. In all patients regeneration of the donor site mucosa was good. During the follow-up period of 4-18 months scar formation at the lower vestibulum was noticed as the only complication. Permanent limitation of mouth opening, stenosis of the parotid duct or hypesthesia did not occur.

Adolescent↗