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Biomedical subjects

J Klemm

Publications and source records attributed to J Klemm.

At least 19 recordsLinked to original sources
PubMed1984

[Treatment of cerebral circulatory insufficiency. Double-blind study of the efficacy of a quinine-papaverine combination].

Four weeks of oral therapy with a combination of quinine and papaverine at a dose of 3 X 1 coated tablet per day cause a marked and--as compared with placebo--statistically highly significant increase (p less than 0.01) in cerebral blood flow of patients with a moderate impairment of the terminal vascular system of the brain. The combination of substances brings about a more pronounced improvement (p less than 0.05) in the cerebral blood flow than papaverine alone which itself is superior to placebo (p less than 0.05). The quinine contained in the combination evidently increases its efficacy. The results of platelet aggregation tests, performed simultaneously, suggest that rheological factors in the sense of an improvement of the flow properties of the blood might play a part in causing these effects. Clinical and neurological findings indicate a clear parallel with the results of the measurements of the cerebral blood flow, even though this was not statistically significant.

Cerebrovascular Circulation↗
PubMed1980

Microbiological quality of Queensland stockfeeds with special reference to salmonella.

One hundred Queensland stockfeeds were examined for their counts of total aerobic bacteria, coliforms, fungi and salmonellas. The total aerobic bacteria, coliform and fungal counts were significantly higher (P < 0.005) for mashes than for crumbles and pellets and salmonellas were isolated from significantly more (P < 0.005) mashes (64%) than pellets and crumbles (8%). Counts of less than 1 salmonella per 100 g were found in 36.4% of the 44 positive feeds. The remainder of the counts ranged from 1.2 per 100 g to greater than 147 salmonellas per 100 g feed.

Aerobiosis↗
PubMed1980

Tc-99m-labeled red blood cells for the measurement of red cell mass in newborn infants: concise communication.

In vitro and in vivo investigations were performed to examine the binding of Tc-99m to neonatal red blood cells (RBC). Labeling efficiency was about 90%, and unbound Tc-99m less than 3% after one washing, in premature and full-term newborns and in children. Thus presence of high percentages of fetal hemoglobin (Hb F) did not influence the labeling of RBCs with Tc-99m. RBCs of 11 newborns were hemolysed and the distribution of Tc-99m on RBC components was analyzed. Although Hb F percentage averaged (60.0 +/- 8.1)% (s.d.), only (11.9 +/- 3.7)% of Tc-99m was bound by Hb F, whereas (45.0 +/- 6.1)% was associated with Hb A. RBC membranes bound (13.7 +/- 4.3)% and (29.3 +/- 4.0)% were found unbound in hemolysates. These results indicate that Tc-99m preferentially binds to beta chains. In vivo equilibration of Tc-99m RBCs and of albumin labeled with Evans blue was investigated in five newborn infants. Tc-99m RBCs were stable in each case during the first hour after injection. Elution of Tc-99m from RBCs was (3.4 +/- 1.5)% per hour. Body-to-venous hematocrit ratio averaged 0.86 +/- 0.03.

Child↗
PubMed1977

[Adrevil improves the peripheral blood flow. Results of a study using the 133-Xe muscle clearance method on lower limbs].

The efficacy of Adrevil has been investigated in 35 patients suffering from arterial blood flow disorders in the lower limb. The patients were given a daily dose of 3 X 2 tablets over a period of 30 days. Changes in muscle perfusion were determined by means of the 133 Xenon muscle clearance. The perfusion volume was found to be increased by 8--12% depending on the severity of the clinical state before treatment. The effect of the drug was more pronounced in cases with severe pathological changes prior to treatment. No adverse reactions were observed.

Arterial Occlusive Diseases↗