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Biomedical subjects

J Klinger

Publications and source records attributed to J Klinger.

At least 19 recordsLinked to original sources
PubMed1991

[Treatment of gastric ulcer with sucralfate and famotidine].

We conducted a double blind random study on 79 patients with gastric ulcer: 39 received sucralfate, 1 g 4 times a day (Group 1) and 40 received a single evening dose of famotidine, 40 mg (Group 2). At 4 weeks, endoscopy revealed healing of the ulcer in 46% of patients in Group 1 and 40% in Group 2 (NS). At 8 weeks, corresponding figures were 90% and 75% (NS). All patients were able to complete treatment and minor side effects were reported from all patients, 36% with sucralfate and 28% with famotidine. Thus, sucralfate and famotidine are equally effective for therapy of gastric ulcer. The higher percentage of healing with sucralfate observed in this study was not statistically significant.

Adult↗
PubMed1990

[Primary biliary cirrhosis. The clinical experience in 31 patients].

We analyzed 31 patients with a diagnosis of primary biliary cirrhosis, 29 of them males, aged 23 to 72 years. Liver biopsy was diagnostic in all showing initial findings of the disease in 5. Echotomography and cholangiography demonstrated a patent biliary, tract. Anti-mitochondrial antibodies were present in 94% of patients. Alkaline phosphatase and biliary acid levels were useful for diagnosis. Pruritus was present with varying intensity in all patients, with premenstrual exacerbations in 5 females who had cholestasis of pregnancy or hepatitis caused by progestin drugs before developing cirrhosis. Recurrent urinary tract infection was present in 8 patients, osteoporosis in 24, Sjogren's syndrome in 24 and Crest syndrome in 4. Survival ranged from 1 to 12 years, death being caused by ruptured esophageal varices in 12 patients and by liver failure in 7. Persistence of pruritus and altered liver function tests after cholestasis of pregnancy or hepatitis caused by progestins should lead to investigation of biliary cirrhosis.

Adult↗
PubMed1989

[Campylobacter pylori in children and adults subjected to endoscopy, correlation of endoscopic, bacteriologic and histopathologic findings].

Campylobacter pylori has been associated to peptic ulcer and gastritis. We investigated the presence of C pylori in 17 children and 50 adults who needed endoscopy to investigate upper gastrointestinal symptoms. Gram stain, Whartin-Starry stain and the urease test were used to identify the germ; best results were obtained with the Gram stain. C pylori was present in 5.8% of children and 88% of adults, including all patients with peptic ulcer and 36 out of 39 with histologic evidence of gastritis. However, the germ was also found in 79% of patients with a normal mucosa. Our results suggest that C pylori is frequently present in gastric mucosa of children and adults with upper gastrointestinal problems. Further studies are needed to elucidate its possible pathogenic role in gastritis or peptic ulcer.

Adolescent↗
PubMed1988

Refraction and its components in Melanesian schoolchildren in Vanuatu.

Refraction and its components were measured on 788 Melanesian children and 39 children of other races, aged 6 through 19 years, in the South Pacific island nation of Vanuatu. Of the 788 Melanesian children, 766 (97.2%) were found to have uncorrected visual acuity of 6/6 or better, and 763 (96.8%) were found to have a spherical equivalent refraction between -0.25 and +1.00 D. Only 23 (2.9%) Melanesian children were found to have myopia greater than 0.25 D, only 2 (0.3%) were found to have hyperopia greater than 1.00 D, and only 2 (0.3%) were found to have refractive astigmatism greater than 1.00 D. Mean corneal refracting power was greater for girls than for boys, at all ages, but did not appear to change in any regular manner with age. Mean axial length and mean vitreous length were greater for boys than for girls, at all ages, each increasing approximately 1.0 mm from age 6 and 7 years to age 18 and 19 years. Although the low prevalence of ametropia may be considered to be due mainly to genetic factors, the possibility of environmental factors cannot be excluded.

Adolescent↗
PubMed1987

Immunological capture of nucleic acid hybrids and application to nonradioactive DNA probe assay.

Antibodies specific for DNA:RNA hybrids were coated onto polystyrene test tubes and applied to hybridization assays involving DNA and RNA. Synthetic DNA probes complementary to 16S rRNA of Campylobacter were labeled with biotin and hybridized to ribosomal RNA directly in lysates of bacterial cells. After hybridization, DNA:RNA hybrids were captured with immobilized anti-DNA:RNA antibody, and the biotinylated probe was detected with streptavidin-horseradish peroxidase (EC 1.11.1.7) conjugate. The assay was optimized to detect as few as 70,000 Campylobacter cells in a sample. We compared the utility of this hybridization assay with that of conventional microbiology methods by examination of 1448 stool samples from hospital clinical laboratories. The DNA hybridization assay had a sensitivity of 98.7% (75/76) and a specificity of 98.2% (1347/1372) and overall agreed with 98.2% of the conventional results for a test population that had a 5.2% incidence (76/1448) of Campylobacter infection. The assay is simple to perform and yields results within 2.5 h.

Antibodies↗
PubMed1987

[The bolus problem].

Explore the source record for details and available documents.

Administration, Oral↗
PubMed1985

Reaction of antibody in sera from cystic fibrosis patients with non-toxic forms of Pseudomonas aeruginosa exotoxin A.

Sera from 48 cystic fibrosis patients from two hospitals were screened for antibody against rods, non-toxic macromolecular structures which share antigenic determinants with Pseudomonas aeruginosa exotoxin A. A solid-phase radioimmunoassay employing (125I)-staphylococcal protein A was used to detect anti-rod IgG. Antibodies recognizing rods, exotoxin A, or both antigens, were demonstrated using a competitive radioimmunoassay in cystic fibrosis patient sera, and in sera from animals immunized with exotoxin A, rods, or infected with Pseudomonas aeruginosa. Anti-rod titers of cystic fibrosis patients (1.07 to 14 X control serum levels) inversely correlated with aggregate clinical evaluation scores, and in most instances, with X-ray scores. Since rods are non-toxic and cross-reactive with exotoxin A, they may represent therapeutically useful antigens for producing immunity to exotoxin A.

ADP Ribose Transferases↗
PubMed1984

Thromboxane, prostacyclin, beta-thromboglobin, and diabetes mellitus.

Plasma levels of beta-thromboglobin (beta-TH) and of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1-alpha, the stable metabolites of thromboxane A2 and prostacyclin, were determined by radioimmunoassay methods in eight patients with noninsulin-dependent diabetes before and after dietary treatment and after administration of the sulfonylurea drug glibenclamide. Blood examinations were performed when hyperglycemia was detected for the first time, four weeks after a dietary regimen was started, and four and eight weeks after glibenclamide treatment was begun. Drug treatment was instituted because, despite a suitable diet, patients' postprandial blood sugar was higher than 8 mmol/L (145 mg/dl). At the initial examination, elevated TXB2 and beta-TH levels indicating platelet hyperactivity and hyperglycemia were found. TXB2 and beta-TH levels decreased significantly after glibenclamide treatment was started, as did the blood glucose level. There was no change in 6-keto-PGF1-alpha. We interpret these results to indicate that diabetes is associated with hyperactivity of platelet aggregation and that control of blood glucose is important because a lower blood glucose level attenuates platelet hyperactivity. Whether the decrease in platelet hyperactivity is a direct result of the lowered blood sugar or reflects the influence of the drug treatment requires clarification.

6-Ketoprostaglandin F1 alpha↗