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Biomedical subjects

J Klopper

Publications and source records attributed to J Klopper.

7 recordsLinked to original sources

Excretion of gallium 67 in human breast milk and its inadvertent ingestion by a 9-month-old child.

The concentration of radioactivity excreted in breast milk following the administration of gallium 67 to 3 patients was measured in milk samples obtained for several days after injection. Similar values were obtained from all 3 patients, with milk samples obtained approximately 120 h after administration containing 4.3-5.7 Bq/ml per MBq of 67Ga administered. These values are lower than those previously reported. The image of a child who had inadvertently been breast-fed for 48 h after administration of 67Ga to the mother showed activity in the intestines only. Our results seem to confirm recommendations by other authors that gallium scintigraphy should be avoided in nursing mothers. Should the administration of 67Ga be inevitable, breastfeeding should be discontinued, since interruption periods of approximately 2 weeks may be required to reduce the effective dose equivalent to the infant below 1 mSv. However, close contact between mother and child need not be avoided.

Adult

Excretion of technetium 99m hexakismethoxyisobutylisonitrile in milk.

The amount of radioactivity excreted in breast milk following the administration of technetium 99m hexakismethoxyisobutylisonitrile (99mTc-MIBI) to a patient referred for cold spot myocardial scintigraphy was determined. During the first 24 h after administration, only 41.2 kBq 99mTc (0.0084% of the injected dose) was excreted in 448 ml milk with the highest concentration of 0.49 kBq/ml in the first sample. The images obtained show a high concentration of 99mTc-MIBI in the lactating breasts contrary to the very small percentage excreted in the milk. Comparison with various recommendations regarding nursing after administration of radiopharmaceuticals seems to indicate that the administration of 99mTc-MIBI does not necessitate an interruption of breast-feeding.

Adult

Excretion of radioiodine in human milk following a therapeutic dose of I-131.

An investigation of 131I excretion into human milk after a therapeutic dose of 5142 MBq (139 mCi) 131I, in a patient who has had a thyroidectomy is presented. During the first 36 h, 17.4% of the administered dose was excreted into the milk. In addition to the known radiation risk, this may affect the quantity of 131I retained by the thyroid and metastases.

Adult