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Biomedical subjects

J Koliopoulos

Publications and source records attributed to J Koliopoulos.

18 recordsLinked to original sources
PubMed1984

Acyclovir--a promising antiviral agent: a review of the preclinical and clinical data in ocular herpes simplex management.

Acyclovir (Aciclovir), previously known as acycloguanosine, has been found to be a potent and selective inhibitor of viruses of the herpes group. A clear therapeutic effect has been demonstrated in animals and in clinical studies, especially for herpes simplex virus (HSV) infection of the eye. Various reports indicate that acyclovir is as effective as or superior to other available antiviral agents with low host toxicity and mild side effects. The possibility of systemic use of this drug and the effect on HSV latency are encouraging, although more evaluation is needed. Acyclovir is a promising new antiviral agent for the topical treatment of HSV ocular infection.

Acyclovir↗
PubMed1983

Epidemiologic research on the role of studying and urban environment in the development of myopia during school-age years.

Four hundred seventy-four Greek male subjects received an ophthalmologic examination and completed a questionnaire. The following were found: (1) the years of studying and urban residence are factors that strongly influence the prevalence of myopia; discriminant factor analysis classified correctly 81% of the subjects into the myopic or the nonmyopic group; (2) the incidence of myopia is significantly higher in the studying v the nonstudying groups; (3) the prevalence of myopia is higher in the more educated group; (4) there is no statistical difference between the orientation of myopes and nonmyopes toward studies or other occupations; (5) although the presence of myopia is determined by the years of studying and urban residence, the degree of myopia is not influenced to a statistically significant level by these factors; and (6) the results indicate that the interaction of these two variables is more significant in their contribution to the onset of myopia than the sum of each variable alone.

Adolescent↗
PubMed1981

Visual correction of keratoconus with soft contact lenses.

Soft contact lenses were fitted on 96 eyes of 52 patients suffering from keratoconus. The visual acuity of 66 eyes was 4/10 or better with soft contact lenses alone. The amount of astigmatism corrected with soft contact lenses varied between 1.50 and 8.00 D, with an average of 2.80 D. Sixteen eyes had a residual astigmatism. Correcting this astigmatism with spectacles resulted in improved visual acuity, and finally, 71 eyes, or 74%, had a visual acuity 4/10 or better. Soft contact lenses of three manufacturers, Bausch & Lomb (the C series), Nusyte, and Bioflex, were used. Thicker lenses corrected more astigmatism and provided an improved visual acuity, especially the C series lenses of Bausch & Lomb, which presented certain advantages in visual correction of keratoconus patients.

Adolescent↗
PubMed1979

Excretion of vanilmandelic acid in the urine of retinoblastoma patients.

The idea of determining the urinary excretion of vanilmandelic acid (VMA) in children with retinoblastoma derives from the fact that elevated amounts of VMA were found in children with neurogenic tumours and especially neuroblastoma. The method of VMA analysis and the results are discussed. In view of the fact that in only 5 out of our 12 patients an elevated urinary VMA excretion was found, we cannot recommend this determination as a routine diagnostic procedure. However, further research in this direction is necessary.

Child, Preschool↗
PubMed1977

Family distribution of concomitant squint in Greece.

From a study of a large number of brothers and sisters suffering from concomitant squint, the following data were obtained: (1) 42-9% of the patients showed congenital strabismus. (2) In 96-5% of the sibs strabismus was of the same type. (3) The presence of a significant refractive error occurred in 82-8% of the patients. (4) In all twins strabismus appeared at the same age in both twins, and the squint and the refractive error were of the same type. (5) The distance of the patients' homes from Athens had no effect on either (a) the time intervening between the onset of squint and the first visit to the eye specialist, or (b) the effectiveness of treatment.

Age Factors↗
PubMed1976

Data concerning colour vision deficiencies amongst 29,985 young Greeks.

In this survey, 29,985 young Greek employees were screened by the Ishihara plates and if necessary by further more detailed methods (including anomaloscope). The examination of 21,231 young males revealed 212 (1.00%) protanopes, 241 (1.14%) deuteranopes, 254 (1.20%) protanomalous, 978 (4.61%) deuteranomalous and 2 with monochromatic vision. In total, 1,678 males (7.95%) had a colour vision disturbance. The examination of 8,754 young females revealed 1 (0.01%) protanope, 2 (0.02%) deuteranope, 3 (0.03%) protanomalous and 31 (0.35%) deuteranomalous; no case of monochromatic vision in females was detected. In total, only 37 (0.42%) females had a detectable colour vision disturbance with applied screening method. These results are discussed and compaired with the available bibliographic data.

Adolescent↗
PubMed1976

Experimental uveitis induced by prostatic antigens.

Experimental uveitis was induced in male rats following their repeated systemic and intravitreous immunization with prostatic antigen and CFA. The ensuing uveitis was proved histologically. Heteroimmunized rabbits and female animals showed less response and the level of antibodies detected was lower. Anti-prostatic antibodies were determined by the TRC flocculation and PCA techniques. Ouchterlony's method gave positive results not only for prostatic but also for other ocular antigens when tested against the same test sera.

Animals↗
PubMed1976

The third component of complement (C'3) level in patients with uveitis.

In 23 cases of endogenous uveitis the third component of the complement (C'3) system was determined by the immunodiffusion method. No statistical difference was found in uveitis patients as a whole in comparison with the normal controls; although a rather high value of C'3 was found in six cases of Eales' disease and in three cases of Behçet's disease. The significance of these results is discussed.

Adolescent↗
PubMedDate not supplied

Comparison of lodoxamide 0.1% ophthalmic solution and levocabastine 0.05% ophthalmic suspension in vernal keratoconjunctivitis.

PURPOSE: To compare the clinical efficacy and safety of lodoxamide 0.1% ophthalmic solution with levocabastine 0.05% ophthalmic suspension, each given four times daily (QID) for three months to patients with vernal keratoconjunctivitis (VKC). METHODS: The study was conducted multinationally according to a triple-masked parallel design in 95 VKC patients, with assessments at baseline then monthly during the three months of treatment. The primary efficacy variables were a Physician's Clinical Judgement Scale and a Patient's Overall Judgement Scale of improvements from baseline. Signs and symptoms of VKC were also assessed. RESULTS: Both primary efficacy variables showed significantly greater overall improvement of VKC from baseline with lodoxamide than levocabastine. The superiority of lodoxamide was demonstrated by the Physician's Clinical Judgement Scale at months 2 and 3, with a trend, at month 1, and by the Patient's Overall Judgement Scale at months 1, 2 and 3. All signs and symptoms of VKC improved significantly from baseline at all time points, regardless of treatment (p<0.001). However, relative to levocabastine, conjunctival discharge, photophobia and lacrimation were significantly reduced by lodoxamide at months 1, 2 and 3, itching at months 2 and 3, and bulbar conjunctiva at month 3. The temporal improvement of superior tarsal papillae did not differ significantly between treatments. Both were well tolerated. CONCLUSIONS: Lodoxamide 0.1% and levocabastine 0.05% eye drops, instilled four times daily for three months, were effective, safe and well tolerated by patients with VKC, but lodoxamide was significantly superior to levocabastine.

Adolescent↗