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Biomedical subjects

J Konja

Publications and source records attributed to J Konja.

26 records · Page 2Linked to original sources
PubMed1977

[Congenital aplastic anemias].

Congenital (constitutional) aplastic anemias in children are relatively rare compared to other diseases but as their outcome is nearly always fatal they are given full attention in pediatric-hematological literature. Although in many patients the number of white cells and thrombocytes as well as of red cells is diminished even in the first phase of the disease (or later in the course of the disease) so that these diseases are really pancytopenias, the term most frequently used to describe these clinical entities is aplastic anemia. The clinical and hematological characteristics of some aplastic anemias (Fanconi's anemia, Blackfan-Diamond's anemia, congenital dyserythropoietic anemia--type I, II, III and IV, etc.) are described. After considering the possible pathomechanisms which bring about aplastic anemia (pancytopenia), information is given about the method of treatment and prognostic prospects with reference to cases treated by the authors.

Anemia, Aplastic↗
PubMed1976

[Results in the treatment of acute lymphoblastic and acute myeloblastic leukemia in children (using Pinkel's and Clarkson's schedules)].

At the Center for the study and treatment of leukemia in childhood (Ward of Hematology, Department of Pediatrics Salata Zagreb) children with acute leukemia are treated by a combined therapy consisting of corticosteroids, chemotherapeutic agents and subjected simultaneously to radiotherapy. The authors present the results achieved in 40 children with acute leukemia (during the period from March 31, 1973 to March 31, 1975.) randomly distributed into three groups. Each group was treated according to a different protocol (using Pinkel's modified scheme for ALL and that of Clarkson for AML), with or without profilactic irradiation of the CNS.

Antineoplastic Agents↗
PubMedDate not supplied

[Sideropenic anemia in infants and toddlers].

Iron-deficiency anemia is the most common anemia in infants. In the routine pediatric care this problem is encountered every day. Numerous factors in infancy (low birth weight, rapid growth, insufficient nutrition) are involved in the development of iron-deficiency anemia, and they must be considered when establishing diagnosis, counselling parents, and prescribing oral iron preparations. Data on 119 patients aged up to two years treated in the Division of Gastroenterology and Nutrition, Pediatric Department, University Hospital Centre Zagreb Salata between 1994 and 1999, were analyzed. We were prompted to do so because of great frequency of iron-deficiency anemia as one of associated diagnoses, and unfortunately often the only diagnosis requiring hospitalization. Out of 119 patients with iron-deficiency anemia, nine (7.7%) patients (four premature newborns and three from twin pregnancy) had to receive transfusion of erythrocyte concentrate due to very bad general condition and low red blood count, accompanied by clinical signs of anemic hypoxia. We also analyzed prenatal and perinatal history, socioeconomic living conditions of these children, i.e. their nutrition, and if they had previously received oral iron preparations. Some of the results, such as inadequate alimentation with flour, as well as insufficient prophylaxis of iron deficiency, which were found in most cases of severe anemia, point to the need of paying greater attention to this problem, better parents education, and more adequate screening for iron deficiency anemia.

Anemia, Iron-Deficiency↗
PubMedDate not supplied

[Results of treatment in non-Hodgkin's lymphoma in children using the YU-77, YU-84 and YU-87 protocols].

Fifty-eight children with non-Hodgkin's lymphomas (NHL) were treated with three different chemotherapeutic protocols at the Division of Hematology and Oncology, Department of Pediatrics Salata during the period from 1977-1989. Twelve (20%) patients had lymphocytic and 46 (80%) lymphoblastic type of NHL. There was no statistical difference in the incidence of the 1st complete remission induced by different chemotherapeutic protocols (YU-77 86% YU-84 72% and YU-87 81%). However, the 1st relapse occurred in 8% of the patients treated with YU-87 protocol, compared to 30% in those treated with YU-84 and 58% treated with YU-77 (p < 0.01). The probability of 36-month survival was highest in patients treated with the most aggressive chemotherapeutic protocol YU-87 (81%), whereas it was 63% in those treated with YU-84 and 32% treated with YU-77 (p < 0.01). All patients that did not enter the 1st complete remission died during the first year of treatment. The median survival of patients that achieved the 1st complete remission was 28.3 months, while the probability of 36-month survival was 62% (p < 0.001). The survival strongly correlated with the protocol employed and clinical stage, but was independent of the histologic type of NHL.

Adolescent↗
PubMedDate not supplied

[Case report of a female patient with autoimmune hemolytic anemia and cold agglutinin antibodies].

We report a case of acute transient cold agglutinin disease, the etiology of which we could not determine with the available methods. Cold autoagglutinins had anti I specificity, high titers of the autoantibody (> 1:1,000) and the thermal range was relative wide. Our patient had severe haemolysis and immunosuppressive therapy with methylprednisolone and cyclophosphamide was administered. It is a question how much these immunosuppresive agents influenced the recovery, and in what extent it was a self limited disease with spontaneous recovery.

Agglutinins↗