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Biomedical subjects

J Kopacz

Publications and source records attributed to J Kopacz.

11 recordsLinked to original sources
PubMed1999

gamma delta T-cells may interfere with a productive immune response in Plasmodium yoelii infections.

Mice lacking alpha beta T-cells or gamma delta T-cells were infected with Plasmodium yoelii 17X NL (non-lethal) and followed for parasitaemia and cytokine production. While the parasitaemia in wild type mice resolved after reaching a peak value of 30 to 50%, it persisted in the -alpha beta T-cell mice until death. However, in the -gamma delta T-cell mice the peak parasitaemia was 12.5% of the levels seen in the wild type and -alpha beta T-cell mice and resolved faster than in the wild type mice. Higher levels of IL-10 and IFN-gamma were consistently found in the wild type and -gamma delta T-cell mice but not in the -alpha beta T-cell mice.

Animals↗
PubMed1999

Murine gamma delta T lymphocytes elicited during Plasmodium yoelii infection respond to Plasmodium heat shock proteins.

gamma delta T cells accumulate during Plasmodium infections in both murine and human malarias. The biological role of these cells and the antigens that they recognize are not clearly understood, although recent findings indicate that gamma delta T cells in general influence both innate and antigen-specific adaptive host responses. We examined the accumulation of gamma delta T cells elicited during infection with virulent and avirulent Plasmodium yoelii parasites in relatively susceptible and resistant strains of mice. Our results indicated that in nonlethal malaria infections, gamma delta T cells comprise a larger proportion of splenic T cells than in lethal infections and that only a live infection is capable of inducing an increase in the percentage of gamma delta T cells in vivo. Furthermore, we demonstrate that gamma delta T cells elicited during a P. yoelii infection respond by proliferation in vitro to P. falciparum heat shock proteins (HSPs) of 60 and 70 kDa, suggesting a possible immunological involvement of parasite HSPs in this arm of the cellular immune response during malarial infection in mice.

Animals↗
PubMed1990

[Surgical treatment of Smith and Barton type fractures].

The method and the results of surgical treatment of Smith and Barton fracture of the distal radial epiphysis has been presented in 10 patients. Dislocation of fragments is reduced after exposure of the palmar side of the distal radial bone. Stabilization is secured by a metal plate, which supports the epiphysis and is fixed to the proximal fragment by screws. It prevents from redislocation of fragments and helps to recover full activity of the hand, which was obtained in 8 patients. Delayed reduction or stabilization of fragments by Kirschner wires in 2 persons has failed.

Adolescent↗