Insulin, thyroxine and glucose in plasma of suckling lambs on low and high fat milk diet.
Explore the source record for details and available documents.
Aging↗
Biomedical subjects
J Koppel
Publications and source records attributed to J Koppel.
Food intake of suckling rats after administration of glucose and amino acids.
The changes of food intake after administration of glucose or a mixture of amino acids were determined in rat pups from the 5th to the 23rd day of life. The milk intake was significantly reduced 90 min after glucose treatment in 17 day-old pups, while decreased food intake after injection of aminoacids was observed only after the 23rd day of life. It is being concluded that the regulation of food intake in correlation to the blood concentrations of various key metabolic factors develops gradually during the suckling period, depending on the development of the CNS and on changes in diet composition.
Amino Acids, Essential↗
Effect of subcutaneous and intraperitoneal administration of insulin on the milk intake of suckling lambs.
Intraperitoneal or subcutaneous injections of Neutral Zn-insulin (4 U/kg b.w.) were given to suckling lambs. Milk intake was significantly increased 8 h and 22 h after intraperitoneal insulin administration; the subcutaneous injection was ineffective. Insulin levels and serum glucose changes were similar in both experimental groups, but we observed significant decrease in total lipids /2 1/2 h, 5 1/2 h), a rise in serum triglycerides (7 3/4 h) and increased serum thyroxine levels (5 1/2 h, 7 3/4 h) after intraperitoneal insulin administration. It is assumed, that intraperitoneal (not subcutaneous) insulin evokes specific biological responses resulting in long lasting hyperphagy in suckling lambs.
Animal Population Groups↗
Effect of insulin and 2-deoxy-d-glucose on the food intake of infant rats.
The effects of glucoprivation on the food intake have been determined in infant rats up to weaning. It was found that insulin reduced the milk intake of 9, 13 and 17-day-old males and females for three hours after treatment. In 24-day-old pups food intake increased for three hours after insulin administration, and decreased during the next 21-hour period. 2-deoxy-D-glucose increased the food intake in 28-day-old rat pups only. It was concluded that the inability of rat pups to correct glucoprivation by a subsequent increase of food intake is a consequence of the inadequate development of hypothalamic regulatory mechanisms. Glucoprivation stimuli are ineffective inducers of short-term hyperphagia of rat pups until the age of 24-28 days.
Animal Population Groups↗
[Changes in blood sugar after administration of xylazine and adrenergic blockers in the rat].
Xylazine (rompun) has sedative, analgetic and myorelaxative effects; in addition to this, it also influences the homeostasis of glucose in the organism. The changes in glucose tolerance were studied in young rats after the administration of xylazine in combination with the blockers of adrenergic receptors. Xylazine caused hyperglycaemia and glucose intolerance in young rats and the administration of the beta-adrenergic blocker (propranolol) prolonged this diabetogenic effect. On the other hand, glucose tolerance after the administration of xylazine with alpha-adrenergic blocker (phentolamine) is close to the normal level. It is supposed on the basis of our results that xylazine-induced glucose intolerance and hyperglycaemia are mediated by the stimulation of the alpha-adrenergic system. Besides inhibition of insulin secretion, hepatic glycogenolysis probably also increases.
Animals↗
The effect of androgen and estrogen on food intake and body weight in rats--age dependency.
The age dependency of changes in food intake and body weight in Wistar rats after androgen and estrogen treatment was followed. The 5 age categories of female rats were treated by androgen and the 6 age categories of male rats were treated by estrogen. The androgen treatment induced an expressive increase in weight gains in all age categories of female rats, except the 1st (after birth), during 25 days from the beginning of the experiments. The increase of weight gains resulted in significantly higher body weight on the 25th day of experiments in the experimental rats. The differences in weight gains among the individual experimental groups after androgen treatment show a rising effect with the age of the animals. There was only a slight increase of food intake in the older experimental groups during the androgen treatment. The estrogen treatment in male rats induced an expressive decrease in weight gains in the 2nd age category (after weaning) and losses of body weight in older experimental groups during 20 days from the beginning of the treatment. The body weight of experimental animals on the 20th day was significantly lower than in the control ones. The losses of the body weight after the estrogen treatment rose with the age of the rats. The food intake was also considerably decreased by estrogen treatments, approximately equally in all experimental groups. The comparison of magnitude of the changes in food intake and body weight after androgen and estrogen treatments indicates that the primary effect of these hormones is their anabolic or catabolic activity which secondarily induces the changes in food intake and its utilization.
Aging↗
Nucleic acids and protein content of some fetal and neonatal rat organs after insulin treatment.
In 17 1/2--21 1/2 day-old fetuses and 1--4 day-old rats the DNA, RNA and protein content of the liver, heart and brain was daily investigated 6 hours after injecting approximately 40 mU . g-1 insulin. The DNA content in the mentioned organs was not affected by the insulin. The RNA content in the fetal and neonatal brain and neonatal heart was significantly elevated, while the liver RNA was not altered. Only in the 4 day-old brain did the protein content increase. The experimental dates indicate that the cell RNA content of some perinatal tissues can be elevated by insulin depending on the type of tissue and its developmental stage.
Animals↗
[Food intake in suckling rats after glycerol administration].
The influence of administered glycerol on the food intake was followed in suckling rats in five age periods (on the 5th, 9th, 13th, 17th and 23rd day of life). Glycerol significantly reduced the food intake (P less than 0.01) in the last three age categories. This finding indicates that from the 13th day of life glycerol becomes one of the limiting factors of food intake for suckling rats in connection with a gradual functional maturing of their control mechanism, regulating the food intake.
Animal Population Groups↗
[The insulin receptor system].
Explore the source record for details and available documents.
Animals↗
Effect of serum glucose changes on milk intake of suckling lambs.
Explore the source record for details and available documents.
Animal Population Groups↗
[The development of the regulation of food intake during ontogenesis--the effect of hyperalimentation on body weight gain in suckling rats].
In an experiment, the number of young rats per nest was reduced to two in time intervals from the 1st to the 6th, from the 6th to the 11th, from the 11th to the 16th, and from the 16th to the 21st day after birth (groups P1, P2, P3 and P4 respectively). The plenty of milk available to the young for a period of five days positively influenced the body weight of the rats in group P2, whereas in the remaining groups the total weight showed no significant change in comparison with normally fed animals. The subsequent normalization of nutrition in the test young (the number of the young in nests was increased to eight) induced a decrease in weight gains in the older test animals (groups P3, P4), whereas in the 6- to 11-day-old rats (P2) the higher weight gains were retained in the next growth stages. The results give evidence that an external interference in the nutrition of rats (hyperalimentation) in the period from the 6th to the 11th day of life can influence, for a longer time, feeding behaviour and weight gains. The relative stability of the body weight of the young after the 11th day of life suggests to the functional involvement of the regulatory mechanisms controlling feed intake in this period of life.
Animal Population Groups↗