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J Koren

Publications and source records attributed to J Koren.

5 recordsLinked to original sources
PubMed2005

[Adenomatoid tumor of the right adrenal gland: a case report].

Adenomatoid tumor of adrenal gland is a very rare primary tumor with favourable prognosis. The mesothelial origin of this tumor was confirmed by multiple studies of various authors. This origin was proven by immunohistochemical and ultrastructural examinations. In our case report, we present an interesting case of the adenomatoid tumor of the right adrenal gland in a 55-year-old woman. Our case is the second well-documented case of this tumor occurring in a female adult patient. We emphasize the presence of an intraluminal thread-like bridging strands, generally considered to be a characteristic histologic feature of this tumor, which have not yet been reported in literature in adenomatoid tumor located in adrenal glands.

Adenomatoid Tumor↗
PubMed2004

[Columnar cell carcinoma of the thyroid gland--case report].

Columnar cell carcinoma of the thyroid gland is a very rare malignant tumour with characteristic histological features. The tumour is characterized by typical aggressive behaviour and unfavourable prognosis. We describe a case of this carcinoma in 69-year-old man. We present clinical and histological features of this tumour. In addition, we present features of this tumour in fine-needle aspirates, which were described only in a few cases in literature so far.

Aged↗
PubMed2002

[Pseudomalignant changes in benign phyllodes breast tumor].

Phylloides tumor of the breast is well known entity in pathology for a long time. It includes fibroepithelial tumors of the different biological character. They are generally divided into three groups: benign, low-grade malignant (borderline) and high-grade malignant. Adenoses of the breast are a group of the benign lesions, the main feature of which is the proliferation of the glandular component of the breast. More frequent adenoses occurring in practice are: blunt duct adenosis, sclerosing adenosis, nodular adenosis, adenosis tumor and florid adenosis. The less frequent adenoses are: microglandular adenosis, tubular adenosis, apocrine adenosis, and myoepithelial (adenomyoepithelial) adenosis. In this article two histologically unusual lesions of the breast in middle-aged women are presented, consisting of the benign variants of the phylloides tumor, modified distinctly by various types of adenoses, which can cause, together with intensive myoepithelial proliferation, great diagnostic problems, especially on frozen sections. They may be mistaken with invasive ductal or lobular cancer. Reliable differentiation between these entities is possible only by using of the immunohistochemical methods.

Adult↗
PubMed1996

Susceptibility and reactivity of sheep to Trichinella spiralis infection.

Susceptibility and reactive manifestation to Trichinella spiralis infection were studied in atypical hosts (sheep) for the period of 247 days. Sheep produced anti-Trichinella antibodies as early on Day 11 (low titer 1:200), with maximum reached at Day 35 (titer 1:800). From Day 42 the antibody level was declining with a negative result of examination on Day 70. Mice exhibited anti-Trichinella antibodies only on Day 32 (titer 1:200). This level was rising, reaching high titer (1:1600) on Day 56. This antibody level persisted until Day 156. In the following period, a rapid decrease in the titer was observed (Graph). On Day 32, T. spiralis larvae in sheep were present in all groups of the muscles examined. The highest larval counts during the entire experiment were detected in the masseter. The initially high counts in the diaphragm and tongue were reduced to only 1/4 or 1/10 at the end of the experiment. In mice, the larvae occurred evenly throughout the entire experiment (Tab. I). The first appearance of a capsule around the T. spiralis larva in muscles was observed on Day 32 p. i. No cell response was detected around the capsule (Fig. 1). Neither was any response observed around necrotizing larvae, even though the surrounding myofibrils were caused to die off (Fig. 2). Certain differences in the degree of myofibril degradation by larvae were evident as early as on Day 32. The least damaged myofibrils were those in the masseter, tongue and diaphragm. This finding correlates with the histological recovery of a different number of necrotized larvae from the individual muscle groups examined. Fresh blood extravassations around larvae were observed on Day 59 (Fig. 3). They could be caused by the migration of larvae to a parasitation site. Live uncapsulated larvae were also found on Day 115 p. i. (Fig. 4). An increased cellular presence around some larvae was observed on Day 84. The larvae surrounded by lymphocytes consequently died off, those without lymphocytic responses formed capsules and survived (Fig. 5). The necrotizing larvae were subject to a powerful phagocytic process, presented by histiocytes, forming multinuclear symplasms (Fig. 6). On Day 11 p. i., larvae inside a capsule were dying off as well. The initial stage of larval necrosis in a capsule is also accompanied by an increased lymphocytic response (Fig. 7). The condition of larvae in capsules and the cellular unresponsiveness as late as on Day 247 indicate the long-lasting viability of the larvae. The capsules surrounding T. spiralis larvae in mice were distinctly seen as early as on Day 32 p. i. Lymphocytic aggregations around the capsule were observed throughout the entire experiment (247 days)-Fig. 8.

Animals↗