PubMed Health⌕ Search

Biomedical subjects

J Kornafel

Publications and source records attributed to J Kornafel.

23 records · Page 2Linked to original sources
PubMed1984

[Endodermal sinus tumor--a contribution to the clinical aspects of ovarian tumors].

Two cases of endodermal sinus tumor (EST) are described in a 19-year-old girl and a 50-year-old menopausal women, respectively. Exstirpation uteri totalis cum adnexis was carried out in both cases. According to the FIGO the tumors were classified as Ic. The histologic diagnosis of EST was based on the presence of elements such as extraembryonic mesoderm, yolk sac mesoderm, vascular structures with Schiller-Duval bodies, PAS-positive globules in Duval sinus spaces. In the first case, where the proposed chemotherapy was refused, the patient died 4 months later with symptoms of abdominal metastases. In the other case, chemotherapy was applied according to the VAC program. At 13 months of the treatment a relaparotomy was made and the lymphatic nodes taken showed no metastases. Three months later, the tumor relapsed and the patient died at 22 months of the therapy. In the light of their observations and literature data the authors recommended a radical surgical intervention combined with intense polychemotherapy as the only effective approach to the problem.

Adult↗
PubMedDate not supplied

Lactoferrin-induced up-regulation of zeta (zeta) chain expression in peripheral blood T lymphocytes from cervical cancer patients.

Alteration of T-cell-associated signal transduction molecules has recently been implicated in immune suppression in tumour-bearing hosts. Here we report the immunoregulatory effects of human lactoferrin (LF) on zeta-chain expression in peripheral blood T lymphocytes from cervical cancer patients and healthy donors. By quantitative flow cytometry analysis, we demonstrated that the mean zeta-chain expression was significantly higher in freshly-isolated T lymphocytes from healthy donors (69%), compared with the patients (38%). Following 3-day culture under standard conditions, zeta-chain expression in T lymphocytes from the patients increased significantly, whereas it dropped in the cells from healthy donors. Anti-CD3 MoAb as well as LF, significantly increased expression of zeta-chain in T cells both from patients and control subjects. The addition of LF to the anti-CD3 MoAb cell cultures resulted in an even higher stimulation of the zeta-chain expression. The results suggest that, in patients with cervical cancer, zeta-chain defects could be corrected by the therapeutic application of LF.

Antibodies, Monoclonal↗
PubMedDate not supplied

[CA-125 antigen in patients with cancer of the uterine body].

In 72 patients with malignant neoplasms of uterine body the serum concentration was determined of CA 125 antigen. In 38 cases serum samples were taken before oncological treatment and in 34 cases after the first stage of treatment. It was found that CA 125 concentration was significantly higher in patients before the treatment, with higher values in more advanced cases and in poorly differentiated tumours. The sensitivity of the CA 125 test was however low in the studied material (19.4%) at cut-off threshold 35 IU/ml, and routine determination of this antigen in serum to be without diagnostic value in uterine body malignancy.

Adenocarcinoma↗