Biomedical subjects

J Korsukewitz

Publications and source records attributed to J Korsukewitz.

12 recordsLinked to original sources

PubMed1985

[Idiopathic ventricular tachyarrhythmia. Spontaneous variability and effect of various antiarrhythmic agents].

20 patients with idiopathic complex ventricular arrhythmias received propafenone 450 mg/d, disopyramide 600 mg/d and metoprolol 100 mg/d. Before commencement of the 3-week treatment period the 95% normal range for spontaneous changes in ventricular extrasystoles (VES), as couplets and runs, were determined from three 24 h-ECG recordings in each patient under drug-free conditions. A drug effect was assumed when the rate of VES/24 h for the control period decreased by greater than or equal to 83.5% or increased by greater than or equal to 505% in the test period. The frequency dependent normal range for couplets varied between a decrease from 100% to 92% (greater than or equal to 16 to greater than or equal to 44/d) and an increase from 650% to 1000% (greater than or equal to 3 to greater than or equal to 38/d) and for runs between a decrease from 100% to 85% (greater than or equal to 6 to 32/d) and an increase from 600% to 1000% (greater than or equal to 1 to 14/d). A decrease in all rhythm disturbances under the action of the 3 drugs could be shown for the whole group (P less than 0.01). On the basis of the calculated normal range, ventricular extrasystoles in the patients decreased significantly by 26-37%, couplets by 13-33% and runs by 0-55% depending to the drug. A drug dependent arrhythmogenic effect occurred in 4 patients. A preference for one or other of the drugs could not be established statistically.

Adult↗

PubMed1985

Late potential-like deflections in the ST segment of normal subjects.

Irregular high frequency deflections of low amplitude have been found within the ST segment immediately following the QRS complex and in the T wave of high resolution bipolar recordings (lead V4-V7) in single beats as well as in averages of 100 beats. The signals in the T wave, found in six out of 22 normal subjects, coincide with the apex of the T wave in standard lead II. Their amplitude depends on the phase of the respiratory cycle. They were most pronounced during expiration. The occurrence of these signals depends on the position of the electrodes relative to the position of the equivalent current dipole, which is determined from simultaneous magnetocardiographic measurements. When electrode V4 is systematically shifted these signals vanish or increase, respectively become measurable.

Adult↗

PubMed1985

[Follow-up of late potentials and complex tachycardiac arrhythmias following myocardial infarct over a 2-year period].

50 patients (mean age 53.8 +/- 9.2 years) were studied at 1.5 to 2 months (U1), 12 months (U2) and 24 months (U3) after acute myocardial infarction. Late potentials were registered at the body surface using the signal-averaging technique and a digital Butterworth filter with high pass cut-off frequencies DC, 25, 50, 100 Hz and a low pass cut-off frequency 300 Hz, 18 db/octave, and a 24-hour ECG was recorded. All patients underwent coronary angiography at U1. Late potentials were found at least once during the observation period in 56% of patients, and 18% of patients demonstrated late potentials at all three examinations but up to 38% at one of the three examinations. Complex tachyarrhythmias (Lown class IV) were found at least once in 48% of patients and at all three examinations in 18% but up to 38% at one of the three examinations. Only four patients demonstrated late potentials and complex tachyarrhythmias at all three examination dates. In contrast, 36% of patients showed neither late potentials nor complex tachyarrhythmias at all three examinations. When late potentials and complex arrhythmias were present simultaneously, the former were most often detected at the cut-off frequencies DC, 25 to 300 Hz (p less than 0.05). The median of the duration of late potentials was significantly longer at U1 and U2 when complex arrhythmias were also present. There was a significant relation between late potentials and complex arrhythmias at U1 and U2 (p less than 0.01 and p less than 0.025) and between the latter and disorders of regional wall motion at all examination dates (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1983

[Relation between late potentials, ventricular arrhythmias, left ventricular dysfunction and occlusion time following intracoronary thrombolysis].

25 patients who had undergone intracoronary thrombolysis (ICT) during acute myocardial infarction were studied an average of 9.8 months after the event in order to test the effect of the procedure on the incidence of complex ventricular tachyarrhythmias, late potentials determined by the signal-averaging technique, ejection fraction, and left ventricular asynergy. The relationships between these findings were tested. ICT was successful in 17 patients. There was a statistically significant relationship (p less than 0.05) between demonstrable akinesia and dyskinesia, late potentials, and complex ventricular tachyarrhythmias. Akinesia and dyskinesia and complex tachyarrhythmias were found more often in the 8 patients in whom ICT was unsuccessful than in the remaining 17 subjects (p less than 0.05). In the latter group no relationship was found between duration of occlusion and the incidence of asynergy, complex tachyarrhythmias, and late potentials; occlusion time was more than 200 min in 7 patients and less than 200 min in 10 patients. It is desirable to hold occlusion time below 200 min if there is no collateral circulation to the jeopardized myocardium.

Arrhythmias, Cardiac↗

PubMed1977

[Botulism after eating country smoked ham (author's transl)].

14 persons ate from a country smoked ham in which botulin was found. From this group, two had complaints which suggested a nonspecific food poisoning; two persons died. Of the dead, clinical symptoms of a botulinus intoxication could be ascertained from other people. In one case, botulinus toxin could be demonstrated in the blood, in the other the botulinus toxin was identified on forensic examination in suspensions of the preserved organ and body fluids, in spite of advanced putrefaction. Histological examination of the brain and of the cerebral and peripheral nerves provided no clear indication of the primary disease.

Adult↗

PubMed1973