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Biomedical subjects

J Kosanetzky

Publications and source records attributed to J Kosanetzky.

5 recordsLinked to original sources

Status and outlook of coherent-x-ray scatter imaging.

X-ray scattering, including coherent, incoherent, and resonance (fluorescent) phenomena, is of fundamental importance in contemporary science as a tool to probe the structure of matter at an atomic level. This elevated status is in sharp contrast to the role of x-ray scatter in medical and industrial radiography, where it is generally regarded as an unmitigated nuisance to be corrected for or, preferably, eliminated. We introduce a novel x-radiographic technique [x-ray diffraction computed tomography (CT)] based on measurement of coherent scatter. The physical background to coherent scattering is described in a simple, classical way, and its importance in conventional radiography is demonstrated by using Monte Carlo analysis. Some diffraction patterns of plastics and animal tissues are presented to illustrate the relevance of coherent scattering to material characterization and diagnosis in industrial and medical radiology. An experimental first-generation (single-pencil-beam) CT system has been constructed to demonstrate the feasibility of x-ray diffraction CT. Some diffraction CT and coherent scatter projection images of simple objects are presented. Possibilities for improving the ratio of image contrast to noise and increasing the momentum resolution of the technique are illustrated.

Animals

Coherent scatter in radiographic imaging: a Monte Carlo simulation study.

The significance of coherently scattered radiation in radiographic imaging is investigated using the Monte Carlo simulation technique. Recent data on the form factor of liquid water, which take into account intermolecular interference effects, have been used for the calculation of the coherent differential cross section. The spatial distribution of scattered radiation in the detection plane was calculated separately for coherent and incoherent single and multiple scattering. In the pencil beam geometry, it is found that coherent scattering leaving the object, is almost exclusively single scattering, is concentrated near but not exactly at the transmitted primary beam and dominates over multiple incoherent scattering in this region even for thick objects and polyenergetic radiation. Some consequences concerning the performance of grids, the choice of phantom materials and a new imaging method are given.

Humans

X-ray diffraction computed tomography.

Coherent scattering of x-ray photons leads to the phenomenon of x-ray diffraction, which is widely used for determining atomic structure in materials science. A technique [x-ray diffraction computed tomography (CT)] is described, analogous to conventional CT, in which the x-ray diffraction properties of a stack of two-dimensional object sections may be imaged. The technique has been investigated using a first generation (single pencil beam) CT scanner to measure small angle coherent scatter, in addition to the customary transmitted radiation. Diffraction data from a standard CT performance phantom obtained with this new technique and with an x-ray diffractometer are compared. The agreement is satisfactory bearing in mind the poor momentum resolution of our apparatus. The dose and sensitivity of x-ray diffraction CT are compared with those of conventional transmission CT. Diffraction patterns of some biological tissues and plastics presented in a companion paper indicate the potential of x-ray diffraction CT for tissue discrimination and material characterization. Finally, possibilities for refinement of the technique by improving the momentum resolution are discussed.

Computers

X-ray diffraction measurements of some plastic materials and body tissues.

X-ray diffraction allows the investigation of the atomic or molecular structure of materials. The combination of diffractometry with computerized tomography enables spatially resolved imaging of the diffraction properties of extended objects as described in more detail in a companion article [Harding et al., Med. Phys. 14, 515 (1987)]. We present measured diffraction patterns of some plastics and several biological materials, which allow further optimization of our method and the selection of suitable application areas.

Humans