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J Kröll

Publications and source records attributed to J Kröll.

8 recordsLinked to original sources
PubMed1994

The mitochondrial F1-ATPase and the aging process.

A progressive dysfunction of the mitochondrion probably plays a decisive role in the aging process. In the present hypothesis it is suggested that the functional defect specifically concerns the catalytic subunit of the mitochondrial F1-ATPase. This proposal is based on observations concerning two classical models of the aging process. 1. The Werner syndrome of premature aging is autosomally recessive; meaning that this disorder--in analogy with other recessive inborn errors of metabolism--results from a single specific mutation, typically resulting in an enzyme defect. 2. The strong association between the ATPase activity of the SV40 T-antigen and the process of cellular immortalization in vitro, suggests that the putative enzyme dysfunction could concern an ATPase. The decrease with aging in the activity of the mitochondrial F1-ATPase--the main producer of ATP--could lay behind the progressive lack of homeostasis observed in senescence.

Adenosine Triphosphate↗
PubMed1978

[Verification of the plum pox virus (PPV) using the tray test (author's transl)].

A comparison of 6 host plants reacting by local lesion if infected by the Plum Pox Virus (PPV) demonstrated that beside Chenopodium foetidum Schrad. also Nicandra physaloides (L). Gärtner, Nicardra physaloides violacea Bitter and Verbena officinalis L. are pretty well suitable to verify the PPV serving as locally reacting test plants. Using the tray test, the PPV was verifiable by separated leaves of C. foetidum Schrad., N. physaloides violacea Bitter, N. physaloides (L.) Gärtner and V. officinalis L. Applying experimental conditions precisely defined, an abridgement of the period between infections and development of the symptomes by three days was acquired here, compared with the plant test.

Methods↗