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Biomedical subjects

J Kronenberg

Publications and source records attributed to J Kronenberg.

105 records · Page 6Linked to original sources
PubMed1983

Diagnosis of jugular paraganglioma by radionuclide angiography: concise communication.

Jugular paraganglioma is a highly vascular tumor, slowly growing, extending into the surrounding structures and causing otologic and/or neurologic symptoms according to its location in the jugular bulb region or the middle-ear. In our study, modified vertex and posterior head scintiangiography was used in seven cases. Scintiangiography was positive in all seven, whereas concomitant radiographic studies were limited: four of the seven gave positive findings by transmission computerized tomography (TCT). Only four patients underwent angiography, with positive results in two. Hypocycloidal tomography was positive in three cases. However, some radiographic studies, particularly TCT, may be useful in detecting local extension, bone destruction, and soft-tissue infiltration. Radionuclide angiography proved highly reliable and should be used initially whenever a jugular paraganglioma is suspected.

Aged↗
PubMed1981

The disposition of 10-10' oxybisphenoxarsine (OBPA) in rats, rabbits and guinea pigs.

The disposition of 10-10' oxybisphenoxarsine (OBPA), a potent, wide spectrum anti-microbial agent widely used in plastics, was investigated in rats, guinea pigs and rabbits. All animals were given a single dose of [U-14C]OPBA by gavage. Urine and feces were collected daily for 7 days, at which time the animals were sacrificed and tissue samples removed for analysis. In all three species, approximately 90% of the administered dose was excreted within 7 days. The rabbits and guinea pigs excreted about 58% via the feces and 32% via the urine. The rats, however, excreted 82% via the feces and 10% via the urine. There were significant differences in the tissue distribution of radio-activity between the three species. The most prominent difference was that the erythrocytes of the rat retained 3.2% of the administered radiolabel while only 0.08% and 0.03% of the dose remained in the erythrocytes of the guinea pig and rabbit, respectively.

Animals↗
PubMedDate not supplied

Clozapine for tardive dyskinesia in adolescents.

Thousands of adolescents use neuroleptic drugs over extended periods of time for a wide range of mental disorders. One of the most severe adverse effects of neuroleptic drugs is tardive dyskinesia (TD), for which no successful treatment is currently available. Clozapine is a known atypical neuroleptic drug with few extrapyramidal side effects. It has been suggested that clozapine may be beneficial for the treatment of tardive dyskinesia in adolescents. However, the efficacy of the drug in adolescents is unknown. This report describes the beneficial effect of clozapine on tardive dyskinesia in two adolescents with schizophrenia.

Adolescent↗
PubMedDate not supplied

Peritonsillar abscess: recurrence rate and the indication for tonsillectomy.

Two hundred ninety patients treated for peritonsillar abscess (PTA) between 1970 and 1982 were reviewed. The patients were divided into those with a history of recurrent tonsillitis prior to developing PTA (72 patients, 25%), and those without (218 patients, 75%). The patients in the first group had four times more recurrences than those in the second group (40% versus 9.6%). Patients older than 40 years were found to have a lower incidence of throat infections than younger patients, and no PTA recurrences were observed. Neither subsequent tonsillitis nor recurrent PTA was observed among 72 patients (25%) who underwent tonsillectomy 6 to 12 weeks after PTA. The pre-PTA history was found to be a dominant factor in determining the need for tonsillectomy. In patients who suffered from recurrent tonsillitis prior to PTA, tonsillectomy is recommended. In those with a single episode of PTA and no history of tonsillitis, tonsillectomy is not indicated.

Female↗
PubMedDate not supplied

Rapidly progressive hearing loss as a symptom of polyarteritis nodosa.

The hearing loss that occurs in polyarteritis nodosa is due largely to middle ear effusion but usually appears as a mixed type. Pure perceptive hearing loss is rare; only two cases have been reported previously in which sensorineural hearing loss was the initial sign of the disease. A case of profound, rapidly deteriorating perceptive hearing loss in which the etiology was not clear is described. One year after the onset of hearing loss, other manifestations of polyarteritis nodosa led to the diagnosis.

Aged↗
PubMedDate not supplied

Coincidental supraorbital neuralgia and sinusitis.

Headache interpreted as treatment failure may be encountered after FESS or pharmacological treatment for chronic sinusitis. This persistent symptom may lead, even in the presence of minimal sinus disease, to frequent office visits, medical treatment, primary surgery, and revision procedures. A prospective study of patients with a documented history and imaging-verified sinus disease with persistent atypical refractory headache were evaluated. Diagnostic measures included injection of local anesthetic and response to carbamazepine. Severe neuralgia of the supraorbital nerve was identified in 11 patients with chronic sinusitis, treated either medically or surgically before inclusion in the study. Eight of the patients underwent surgery for sinus disease, and five of them had revision surgery because of persisting complaints. All patients responded favorably to the local injection, and eight were treated with carbamazepine. In certain cases, headache in sinusitis patients may be caused or aggravated by supraorbital neuralgia. Sinus disease is possibly a causative factor but conceivably plays the role of a "red herring." This readily diagnosed and treated coexistence may be more prevalent than recognized formerly.

Adult↗
PubMedDate not supplied

Functional endoscopic sinus surgery: experience with the first 100 patients.

Retrospective analysis of the data on the first 100 rhinosinusitis patients who had undergone functional endoscopic sinus surgery (FESS) is presented. High rate of good-excellent results (79%) and low rate of complications (17%, all minor) are satisfactorily comparable to those reported from other centers.

Adolescent↗