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J Kuhlman

Publications and source records attributed to J Kuhlman.

6 recordsLinked to original sources
PubMed1995

Digital chest radiography: comparison of unprocessed and processed images in the detection of solitary pulmonary nodules.

PURPOSE: To compare the accuracy with which simulated solitary pulmonary nodules can be identified on digital images of the chest that are unprocessed, processed with adaptive spatial filtering, or processed with global filtering. MATERIALS AND METHODS: Six experienced chest radiologists evaluated 408 test radiographs (136 from each of the three types, half with simulated nodules) and judged whether a nodule was present. Data from the 2,448 observations were evaluated by means of a receiver operating characteristic curve with location methods. RESULTS: Accuracy was significantly better with the adaptive filter technique than with the global technique (P < .05), and it was better with adaptive filtering than with no processing in the detection of pulmonary nodules in the mediastinal-subdiaphragmatic areas (P < .05). No significant difference was found between no processing and global filtering. CONCLUSION: Adaptive filtration is superior to global filtration in the identification of solitary pulmonary nodules and is superior to no processing in nodules projected over the radiopaque areas of the thorax on digital images.

Algorithms↗
PubMed1995

Pancreatic adenocarcinoma: CT versus MR imaging in the evaluation of resectability--report of the Radiology Diagnostic Oncology Group.

PURPOSE: To compare findings with computed tomography (CT) and magnetic resonance (MR) imaging in pancreatic adenocarcinoma and to determine optimal pulse sequences for MR imaging. MATERIALS AND METHODS: CT scans and MR images were compared of 189 adult patients with known or suspected adenocarcinoma of the pancreas. Levels of confidence were correlated with surgical and pathologic results. RESULTS: The accuracy of CT was 0.73 and of MR imaging was 0.70. The negative predictive value of CT was 0.28 and of MR imaging was 0.23. The positive predictive value of CT was 0.89 and of MR imaging was 0.88. Gradient-echo and T1-weighted spin-echo sequences ranked equally in evaluation of vascular invasion, T1-weighted spin-echo sequences were preferred for assessing lymphadenopathy, and T2-weighted spin-echo sequences were preferred for detecting hepatic metastases. CONCLUSIONS: Cross-sectional imaging modalities are useful in the identification of unresectable pancreatic carcinoma. CT is recommended for initial imaging assessment.

Adenocarcinoma↗
PubMed1993

T-cell lymphokine response to orally administered proteins during priming and unresponsiveness.

Feeding antigens induces an immunological unresponsiveness termed oral tolerance but under some conditions, for example following the administration of cyclophosphamide (CY), immunity can be induced. These observations have usually been made by studying antibody production and delayed hypersensitivity with little attention given to other measurements of cellular activation. We have therefore examined the lymphokines produced by T cells obtained after the induction of oral tolerance or intragastric priming. Cells isolated from the spleen and Peyer's patches (PP) of tolerized mice could secrete high levels of interferon-gamma (IFN-gamma) and moderate levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) in response to antigen while interleukin-2 (IL-2), IL-3 and IL-4 could not be detected. Mesenteric lymph node (MLN) cells of tolerized mice did not respond to antigen unless spleen adherent cells were added to the cultures where IFN-gamma and GM-CSF were produced. Intragastric priming was achieved by feeding antigen to CY-treated mice. T cells from the spleen, MLN and PP of these mice could produce GM-CSF, IFN-gamma, some IL-3 but little or no IL-2 and IL-4. The ability of MLN cells to proliferate with antigen in vitro was low and corresponded to low IL-2 production. Thus T cells from fed mice secrete a defined pattern of lymphokines which differs in tolerizing and priming regimes.

Administration, Oral↗
PubMed1989

Computed tomography of uterine sarcomas.

Uterine sarcomas are rare tumors, comprising only 2% of uterine malignancies. Abdominal and pelvic computed tomography (CT) of 14 patients with pathologically proven uterine sarcomas were reviewed. The average age of patients in our series was 64 years. The primary tumor measured between 4 and 30 cm. CT characteristics of uterine sarcomas included a low density mass within the uterine cavity in 12 of 14 cases. In two cases the mass was nearly isodense with uterus. Tumor necrosis was present in eight cases. Two patients presented with sarcomatosis, two demonstrated nodal spread, and one had liver metastases. Hydronephrosis was seen in three cases.

Aged↗
PubMedDate not supplied

CT evaluation following Whipple procedure: potential pitfalls in interpretation.

A series of 41 CT examinations in 14 patients who had undergone a Whipple procedure for pancreatic cancer followed by adjuvant chemotherapy and radiation therapy were reviewed to determine the spectrum of CT findings, as well as to identify potential sources of error in interpretation. Thickening of the wall of the gastric antrum and proximal duodenum from 5 to 10 mm (9 of 14 patients) occurred as early as 1 month after completion of radiotherapy and simulated recurrent tumor. Unopacified anastomotic bowel loops in the porta hepatis in 23 of 41 examinations (56%) also mimicked recurrent tumor or adenopathy. Five of 14 patients showed liver metastases and 4 of 14 had recurrent disease in the pancreatic bed. Pneumobilia (33 of 41 examinations) was a frequent normal finding.

Adult↗