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Biomedical subjects

J Kulhánková

Publications and source records attributed to J Kulhánková.

At least 19 recordsLinked to original sources
PubMed1997

[Squamous intraepithelial lesions in young female university students].

The authors investigated the frequency of squamous intraepithelial lesions (SIL) in young women, in particular university students with special attention to morphological signs of the presence of human papilloma virus (HPV) in SIL low grade-SIL, LG-HPV. As compared with data in the world literature, they revealed a significantly lower rate of SIL LG, HPV-2.81% as compared with 5.5% reported in WHO studies of young women. The authors analyzed the biological behaviour of SIL, LG-HPV. As compared with data in the literature on known values of spontaneous regression which are 50-62% in the course of three years, they demonstrated during a time interval from 3 months to 2 years spontaneous regression in 39.1%. Further possibilities of regression in a longer time interval are expected in the group of clinically latent cytologically persistent LG lesions (18.1%) and in the group of patients which after termination of their studies were lost from the records (24.3%). During the investigated time interval no case of progression to a higher grade lesion was recorded. The authors reflect on diagnostic and therapeutic procedures with regard to the application of results of HPV typing.

Adolescent↗
PubMed1989

[Inverted papillomas].

Inverted papilloma is a relatively rare benign tumour of nasal mucosa and paranasal sinuses which approx. in 15% is connected with malignancy. The morphology, occurrence, etiology and biological behaviour of this tumour are dealt with. A group of 8 patients is presented. The significance of nasal polyps routine histologic investigation for early detection of these tumours is stressed. Various treatment possibilities are discussed and a therapeutic procedure based on radical surgery is suggested.

Adult↗
PubMed1986

Monoclonal antibodies against human leucocyte antigens. I. Antibodies against beta-2-microglobulin, immunoglobulin kappa light chains, HLA-DR-like antigens, T8 antigen, T1 antigen, a monocyte antigen, and a pan-leucocyte antigen.

Monoclonal antibodies against several human leucocyte cell surface antigens were prepared and characterized: B2M-02, a non-cytotoxic antibody against beta-2-microglobulin; MEM-09 and MEM-40, against immunoglobulin kappa-type light chains; MEM-12, MEM-24G and MEM-32B, all against a monomorphic determinant in MHC class II antigens, presumably HLA-DR, dependent on the association of alpha and beta chains; MEM-15 and MEM-18, against a monocyte antigen of 55 kDa; MEM-28, against a 200 kDa antigen expressed on all leucocytes; MEM-31, against the T8 antigen of the cytotoxic/suppressor T-lymphocyte subpopulation; MEM-32, against the T1 antigen of T lymphocytes.

Animals↗
PubMed1985

[Peripheral T-malignant lymphoma (PTML)].

Twelve cases representing variants of peripheral T malignant lymphoma were described for the first time in this country. Rosette test and immunocytology were crucial for their identification. Convoluted nuclei were a dominant histologiial feature as well as a voluminous water-clear cytoplasm which kept being surprisingly well demarked. Basic features were analogous to the Far East cases. Nevertheless, hypercalcemia and substantial pulmonary lesion were not observed.

Adult↗
PubMed1984

[More detailed criteria for distinguishing lymphatic and reticular cells using electron microscopy].

About 100 illustrative cases of malignant lymphoma and non-tumorous lymph node processes studied by electron microscopy were revised. Some distinguishing features were stressed as about nuclear patterns and intercellular relations of basic lymphatic elements. The centrocyte is unique in a fine chromatin pattern of the cleft nuclei and in varied superficial qualities. It tends to form junctions with dendritic cells and bilateral dense bodies remaining from severed cellular projections. The centroblast and immunoblast represent a different structural line related to plasmacytes and macrophages or epitheloid cells. The T-line tends to form characteristic junctions with interdigitating cells as well as dense invaginations of cytoplasmic membrane on the both sides of junctions. There is a limited number of similar junctions with pericytes. Dense bodies produced at the junction of lymphatic and stromal reticular cells are discussed.

Humans↗
PubMed1984

[Persistent atypical epitheloid component of malignant lymphomas].

Three cases of immunoblastic B sarcoma were found in a group of 38 patients suffering from lymphoepitheloid malignant lymphoma where atypical epitheloid cells did not occur temporarily. Taking some morphological and even histochemical features of tumour cells they reminded of hybrid forms. This stimulating finding was difficult to explain. Persons in the study were of higher age, case histories showed high grade malignancy with a rather good reaction to cytostatic treatment. The picture is to be followed further as a subunit isolated from the wide rank of lymphoepitheloid malignant lymphoma.

Epithelium↗
PubMed1984

[Histocytology of lymphatic tissue].

A more detailed analysis of lymphatic tissue showed its sophisticated cytology. About 35 types of cells shared in structure in a confined space. Their most important diagnostic criteria in the light and electron microscopy, histochemistry, and immunohistology were reviewed. Testing group features in advance seemed to be advantageous beginning with lymphocytes, lymphoplasmatic elements, polymorph lymphatic cells, lymphoblasts, histioreticular and vascular cells. A further subgrouping is mostly feasible especially by electron microscopy.

Humans↗
PubMed1980

[Pulmonary lymphangioleiomyomatosis].

The second and third cases of this rare entity reported on in Czechoslovak literature were observed in two females, one 59, the other 24 years old. In both, there was typical diffuse pulmonary involvement with honeycomb transformation, recurrent spontaneous pneumothorax, and cor pulmonale decompensation. In the older patient, there was, at the same time, pronounced paraoesophageal node leiomyomatosis. In the younger one, there were associated renal and hepatic angiomyolipomas such as are found in tuberous sclerosis.

Adult↗