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Biomedical subjects

J Kulig

Publications and source records attributed to J Kulig.

At least 19 recordsLinked to original sources
PubMed1992

Dietary practices in households as risk factors for stomach cancer: a familial study in Poland.

In the framework of a nationwide case-control study of risk factors for stomach cancer, a household survey was conducted on those food habits at the family level which were considered relevant for stomach cancer. The practices of 741 case and 741 control households were compared and relative risks calculated by the unconditional maximum likelihood method. For each household, the person responsible for cooking completed the survey. Respondents to the household survey were 35% of the cases and 40% of the controls of the case-control study and otherwise other household members. Case households relied more frequently on their own gardens as a major source of vegetables and fruit, and they cooked their vegetables more often than control households. The vegetable and fruit consumption during the summer period per family member was significantly less in case households compared to control households. The difference in per capita vegetable and fruit consumption between case and control households persisted, but was considerably less pronounced when the consumption of the index person (case or control) was subtracted from the household consumption. The consumption of mainly wholemeal bread showed a relative risk (RR) of 0.18 (95% CI 0.07-0.44) compared with mainly white bread consumption, whereas frequent frying and stewing of meat was associated with an increased risk compared to boiling of meat (RR = 2.06, 95% CI 1.48-2.87). No association with risk was found for long-term refrigerator use or other storage modalities.(ABSTRACT TRUNCATED AT 250 WORDS)

Case-Control Studies↗
PubMed1992

T-cell-dependent popliteal lymph node reactions to platinum compounds in mice.

The requirements for sensitization to complex salts of platinum were investigated in a mouse model by means of the popliteal lymph node (PLN) assay. A single subcutaneous injection of dissolved hexachloroplatinates without adjuvant induced a vigorous primary immune reaction in the draining PLN. Dose-dependent lymph node activation was determined by an increase in both PLN weight and cellularity. In C57BL/6 mice, peak reactions were obtained around day 6 after administration of 90-180 nmol Na2[PtCl6] or (NH4)2[PtCl6] per animal. Mice primed to [PtCl6]2- mounted an enhanced response upon local restimulation with suboptimal doses of the same but not unrelated compounds, indicating a specific secondary response. T cells were required to elicit PLN reactions to [PtCl6]2-, because athymic nude mice completely failed to respond, in contrast to their +/nu littermates. Differences between various inbred strains of mice revealed that Pt-induced PLN responses are genetically controlled. Moreover, the immunogenicity of Pt salts in mice is not confined to hexachloroplatinates, but other compounds, such as the antineoplastic agent cis-dichlorodiamine platinum, are able to induce comparable PLN reactions.

Animals↗
PubMed1992

[Tobacco smoking and alcohol consumption as risk factors for stomach cancer in different locations and histologic types].

A multicancer hospital based case-control study involving interviews with 741 incident male and female gastric cancer cases under the age of 75 years and an equal number of age and sex matched controls has been carried out in Poland. Smoking cigarettes without filter increased the risk for intestinal cancer in the cardia part of the stomach (OR = 3.72, 95% CI: 1.35-10.23). Relative risk of the intestinal type of cancer in the distal part of the stomach was augmented with the increasing frequency and amount of vodka drinking. Subjects who drank vodka at least once a week had about 4.5 times the risk of intestinal cancer of the gastric corpus compared to non-drinkers (RR = 4.45, CI: 2.26-8.75). The relative risk of intestinal carcinoma in the distal stomach due to vodka drinking among those who used to drink vodka on an empty stomach was also elevated (RR = 3.28, CI: 1.33-8.13), but the effect of years of vodka drinking habit failed to show significant association with gastric cancer. A weak interaction effect between smoking and vodka drinking was found for intestinal cardia cancer. Diffuse type gastric carcinoma or mixed type carcinoma were not significantly related to smoking or vodka drinking habits.

Aged↗
PubMed1991

Does microhistology improve the cytological diagnosis of liver and pancreatic tumours?

Guided percutaneous fine needle aspiration cytodiagnosis of the liver, retroperitoneum and pancreas was performed in 197 patients. In 42 cases, material left after the smears were prepared was embedded in paraffin wax for histological examination. Six liver tumours and seven pancreatic tumours were identified in this material. In two cases the diagnosis of liver cell carcinoma was made only after microhistological examination. Re-examination of the cytological material in both cases disclosed features of liver cell carcinoma which were underestimated in the first examination and diagnosed only broadly as cancer cells. On the other hand, in another case cancer cells were present only in the smear and absent in the microhistological preparation. Diagnosis of pancreatic tumours was generally not improved by microhistological examination. In one case cancer cells were present only in the cytological material. In another case a cytological diagnosis of suspected cancer was confirmed as adenocarcinoma by microhistology. The diagnosis of non-neoplastic material in the remaining 29 cases were identical by cytopathology and microhistology. It is concluded that the microhistology of needle aspirate material complements cytological examination and can refine diagnosis although it increases cost.

Biopsy, Needle↗
PubMed1990

Maternal role of women in clerical jobs in southern Brazil: stress and satisfaction.

The number of women in the work force in Brazil is increasing, and a pattern of early work participation and a later decline continues to be manifested. The maternal role is a central role for these women. We investigated the quality of the maternal role as perceived by women who hold clerical jobs in a southern Brazilian city. Qualitative and quantitative data were collected from a random sample of 60 women. Thirty-three of these women were mothers with one or more children. Maternal role likes, dislikes, and stresses were obtained through questionnaires. Coping strategies and resources to cope with the maternal role needs were also obtained. Analytical categories were developed for each of these variables and the analysis was completed through the use of a qualitative computer program.

Adaptation, Psychological↗
PubMed1990

[Value of ultrasonography for the diagnosis of cholelithiasis in light of surgical verification].

Up to the age of ultrasonography the cholelithiasis diagnostics has been based on the radiologic examination that is on the peroral cholecystography introduced by Graham and Cole in 1924 as well as on the intravenous cholangiography performed for first time by Langecker and Harwat in 1952. During last years the cholelithiasis diagnostics is more and more frequently based on the ultrasonographic examination. The purpose of this study was in evaluation of ultrasonography in detection of cholelithiasis. The diversity of ultrasonographic images according to the cholelithiasis type and the accompanying alterations in the wall and surrounding area of the gallbladder has been taken into account. The USG diagnostic value and that of routine radiologic methods in diagnosis of cholelithiasis has been additionally compared.

Cholelithiasis↗
PubMed1989

A multiclinic trial evaluating arbaprostil [15(R)-15-methyl prostaglandin E2] as a therapeutic agent for gastric ulcer.

A randomized, double-blind, placebo-controlled, multiclinic trial evaluated arbaprostil [15(R)-15 methyl prostaglandin E2] for the treatment of acute gastric ulcer, achieving an overall enrollment of 124 patients (of which 113 were considered evaluable). This 6-wk trial used an arbaprostil dose of 10 micrograms q.i.d., which has little gastric acid antisecretory activity. Endoscopies were performed after 21 and 42 days of treatment, at which times the arbaprostil and placebo healing rates, respectively, were 6/59 (10.2%) and 4/53 (7.6%) on day 21 and 25/59 (42.4%) and 16/50 (32.0%) on day 42. No significant differences between the treatment groups were found for pain relief, antacid consumption, and mucosal healing. This trial documents that a 10-micrograms dose of arbaprostil (which may be considered cytoprotective because of its small effect on gastric acid secretion), although safe and associated with no side effects, is not efficacious in healing acute gastric ulcers.

Acute Disease↗
PubMed1978

Significance of intraoperative fibercholangioscopy in the diagnosis of biliary tract disorders.

Intraoperative fibercholangioscopy allows direct inspection of the entire biliary tree up to the secondary distributaries. In 100 patients with suspected biliary tract pathology on account of endoscopic retrograde cholangiography the following findings were obtained: choledocholithiasis (solitary or multiple) in 66, biliary mud in 4, stricutres in 15, common bile duct carcinoma in 8, choledochal cyst in 1 and extrinsic lesions in 6. Peroral direct transpapillary cholangioscopy is still in an experimental stage but its results are promising.

Biliary Tract Diseases↗