[Patho-morphological picture of stress myopathy in pigs].
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Animals↗
Biomedical subjects
J Kursa
Publications and source records attributed to J Kursa.
[Use of the ECG in bovine cysticerosis].
In two calves with massive cysticercosis and one healthy control calf the method of electrocardiographic examination was applied to a preciser determination of the clinical finding. The examination was performed on the 75th day after the experimental infection. Singly recorded electrocardiographic findings provided no characteristic symptoms indicating an injury of the conductive system of the heart. However, in both infected calves a lowering of the pulse frequency was found and in one of them also a flattening and a change of the polarity of the T wave. Autopsy and histological examination of the heart of the infected calves performed 111 days and 250 days after the infection revealed an attacking of the cardiac muscle by cysticerci and dispersed chronic myocarditis. This finding and the investigated dynamics of pathological changes in the course of cysticercosis in other experimental animals indicate that at the time of the electrocardiographic examination cysticercoid myocarditis at a stage of rest was recorded.
Animals↗
[Electron microscopic studies in enzootic muscular dystrophy in cattle].
Electron microscopy was used to examine the sekeletal muscles of young cattle, aged between 13 and 24 months, with spontaneous enzootic myodystrophy (nutritional myodegeneration due to selenium deficiency, white muscle disease). The animals had been received from Sumava District, Southern Bohemia, an area known for shortage of selenium. Outbreaks of clinical illness were recorded from them between four and 18 days from the beginning of grazing. Most of the ultrastructural changes included decomposition of myofibrils and hyalinisation of fibres as well as defective fibril synthesis (Z-striation abnormality), some of the latter phenomena recordable even from regenerating fibre. However, minor disorders only were established from the mitochondria, sarcoplasmic reticulum, components of sarcoplasm, and vessels. There were far-reaching ultrastructural similarities to nutritional myodegeneration of sheep. The changes recorded are likely to suggest a specific role played by selenium in the formation and preservation of myofibril proteins.
Animals↗
Osmotic and oxidative haemolysis of erythrocytes in calves with white muscle disease.
The stability of erythrocytes to both osmotic and oxidative haemolysis was studied in naturally occuring cases of white muscle disease of calves two to 14 weeks old. During clinical and subclinical disease the incidence of haemolysis when erythrocytes were exposed to 0-588 per cent NaCl was 74-3 +/-18-8 per cent and 76-6+/-18-6 per cent respectively, whereas in clinically healthy animals receiving 30 mg vitamin E per kg feedstuff the incidence of haemolysis was only 55-9+/-12-7 per cent. Erythrocytes of the calves receiving vitamin E supplements were completely resistent to peroxidative haemolysis whereas in the clinical and preclinical cases approximately 12-5 per cent of cells were lysed.
Animals↗
[Proteinemia in young cattle during nutrition-induced muscular dystrophy].
The origin and course of enzootic white muscle disease affecting young cattle in spring months after transfer from stables to pastures were accompanied by an apparent tendency to dysproteinemia. Clinically diseased animals showed a decrease of total protein in the blood serum and considerable changes in the protein spectrum. In comparison with findings in the set of clinically healthy controls, the animals affected by the white muscle disease showed a depression of albumins and a simultaneous increase of alpha- and beta-globulins and a decrease of gamma-globulins.
Alpha-Globulins↗
[Selenium content in cattle hair in areas with incidence of nutrition-induced muscular dystrophy].
In the South Bohemian Region which is an area of enzootic incidence of nutritional muscle dystrophy selenium content in the fur of dairy cows and young cattle was determined. In the breeds in which the "white muscle disease" appeared in the past years in young cattle, lambs and calves the lowest mean selenium values in the fur dry matter found were: 0.18 +/- 0.07, 0.19 +/- 0.06, and 0.21 +/- 0.08 ppm, with repeated findings of mere 0.09 ppm Se. 60 to 100 per cent samples from these farms showed selenium values below the 0.25 ppm level. The fur of heifers which recovered from nutritional muscle dystrophy and were treated 10 days prior to sampling with a selenium preparation in injection form (Selevit inf. SPOFA) contained 0.29 ppm selenium (+/- 0.11). In other breeds 0.30 +/- 0.07 to 3.33 +/- 0.16 ppm selenium was found in the fur of cows and young cattle. The initial field essay of selenium content in cattle fur indicated a relation of low selenium values to the frequency of clinical forms of nutritional muscle dystrophy in domestic ruminants.
Animals↗
[Activity of some serum enzymes in calves suffering from white muscle disease].
The paper described the findings of the activity of aspartate amino transferase (GOT) and alanine amino transferase (GPT), lactate dehydrogenase (LDH), alkaline phosphatase (AP), and aldolase in the blood serum of calves examined for white-muscle disease (WMD). Relapsing mass accurrence of the disease was reported from various agricultural enterprises where calves were fed a milk replacer without vitamin E. In comparison with clinically healthy calves fed a feed mixture with vitamin E, calves suffering from the clinical form of WMD showed an alkaline phosphatase level decrease from 32.3 +/- 7.6 u. K. A. to 15.1 +/- 8.2 u. K. A. On the other hand, the activites of ALD, GOT, GPT, and LDH showed a statistically significant increase. The acute and sub-acute course of the disease increased enzyme activities as follows: ALD from 4.2 +/- 1.1 mumol (= 70.0 +/- 17.0 i.u.) to 9.7 +/- 2.1 mumol (= 163.0 +/- 33.2 i. u.), GOT from 0.9 +/-0.5 mumol (= 68.0 +/- 5.8 i.u.) to 16.7 +/- 11.7 mumol (= 567.0 +/-40.0 i. u.) GPT from 0.2 +/- 0.8 mumol (= 5.0 +/- 12.4 i. u.) to 9.8 +/- 2.8 mumol (= 330.0 +/- 40.4 i.u.), LDH from 46.1 +/- 5.4 mumol (= 765.0 +/- 40.0 i.u.) to 72.7 +/- 24.3 mumol (= 1,207.0 +/- 403.0 i.u.). In WMD-affected herds, similar enzyme activity fluctuations were observed even in calves showing no clinical signs of the disease. It follows from the study that the examination of serum enzymes provides a method to demonstrate the clinical and pre-clinical forms of white-muscle disease and that it can be included in the set of tests for the diagnosis of diseases in calves. The significant differences in all calves in the affected herds show that the disease is a danger to all animals in the herd fed a deficient mixture.
Alanine Transaminase↗
[Activity of various serum enzymes in calves suffering from nutritionally-induced muscular dystrophy].
The paper described the findings of the activity of aspartate amino transferase (GOT) and alanine amino transferase (GPT), lactate dehydrogenase (LDH), alkaline phosphatase (AP), and aldolase in the blood serum of calves examined for white-muscle disease (WMD). Relapsing mass accurrence of the disease was reported from various agricultural enterprises where calves were fed a milk replacer without vitamin E. In comparison with clinically healthy calves fed a feed mixture with vitamin E, calves suffering from the clinical form of WMD showed an alkaline phosphatase level decrease from 32.3 +/- 7.6 u. K. A. to 15.1 +/- 8.2 U. K. A. On the other hand, the activities of ALD, GOT, GPT, and LDH showed a statistically significant increase. The acute and subacute course of the disease increased enzyme activities as follows: ALD from 4.2 +/- 1.1 mumol (= 70.0 +/- 17.0 i. u.) to 9.7 +/- 2.1 mumol (= 163.0 +/- 33.2 i. u.), GOT from 0.9 +/- 0.5 mumol (= 68.0 +/- 5.8 i. u.) to 16.7 +/- 11.7 mumol (= 567.0 +/- 40.0 i. u.), GPT from 0.2 +/- 0.8 mumol (= 5.0 +/- 12.4 i. u.) to 9.8 +/- 2.8 mumol (= 330.0 +/- 40.4 i. u.), LDH from 46.1 +/- 5.4 mumol (= 765.0 +/- 40.0 i. u.) to 72.7 +/- 24.3 mumol (= 1,207.0 +/- 403.0 i. u.). In WMD-affected herds, similar enzyme activity fluctuations were observed even in calves showing no clinical signs of the disease. It follows from the study that the examination of serum enzymes provides a method to demonstrate the clinical and pre-clinical forms of white-muscle disease and that it can be included in the set of tests for the diagnosis of diseases in calves. The significant differences in all calves in the affected herds show that the disease is a danger to all animals in the herd fed a deficient mixture.
Acute Disease↗