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Biomedical subjects

J L Alvarez-Sala

Publications and source records attributed to J L Alvarez-Sala.

At least 19 recordsLinked to original sources

[Spontaneous rupture of the spleen in chronic pancreatitis].

The appearing of splenic complications in the evolution of acute or chronic pancreatitis is a known fact, even though it is not that frequent. A case of splenic rupture happens during an acute bout of chronic pancreatitis. The possible pathogenic mechanisms implied are analysed as well as the forms of presentation and the approximation to diagnosis. The great difficulty in the diagnosis is determined by the scarce specificity of the clinical and biochemical manifestations. Therefore, it is called the attention upon the eventuality of this complication and the therapeutic attitudes which should be adopted.

Chronic Disease

A new Spanish family with Hb Louisville.

The clinical, hematological, and biochemical characteristics of a new family with heterozygous hemoglobin (Hb) Louisville are described. The family showed a decrease in both oxygen affinity and cooperativity with the normal Bohr effect. This family has the greatest number of affected members reported to date. Among the descendants, two first cousins (III-10 and III-11), both of whom are affected by the heterozygous trait of Hb Louisville, had had three abortions of undetermined causes.

Adult

A new family with hereditary choreo-acanthocytosis.

We describe a new family with hereditary choreo-acanthocytosis. Two members of this family were affected; neither of them suffered from anaemia or signs of haemolysis. The acanthocytes showed an impaired deformability with an increase in whole blood viscosity. The composition of the plasma and erythrocyte membrane lipids was normal, as was the fatty acid composition of the erythrocyte ghost membranes. The only alteration found was a decrease in the fluidity of the erythrocytic membrane.

Acanthocytes