Biomedical subjects

J L Barrat

Publications and source records attributed to J L Barrat.

6 recordsLinked to original sources

PubMed2005

Nucleation in hydrophobic cylindrical pores: a lattice model.

We consider the nucleation process associated with capillary condensation of a vapor in a hydrophobic cylindrical pore (capillary evaporation). The liquid-vapor transition is described within the framework of a simple lattice model. The phase properties are characterized both at the mean-field level and with Monte Carlo simulations. The nucleation process for the liquid to vapor transition is then specifically considered. Using umbrella sampling techniques, we show that nucleation occurs through the condensation of an asymmetric vapor bubble at the pore surface. Even for highly confined systems, good agreement is found with macroscopic considerations based on classical nucleation theory. The results are discussed in the context of recent experimental work on the extrusion of water in hydrophobic pores.

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PubMed2004

Intrusion and extrusion of water in hydrophobic mesopores.

We present experimental and theoretical results on intrusion-extrusion cycles of water in hydrophobic mesoporous materials, characterized by independent cylindrical pores. The intrusion, which takes place above the bulk saturation pressure, can be well described using a macroscopic capillary model. Once the material is saturated with water, extrusion takes place upon reduction of the externally applied pressure. Our results for the extrusion pressure can only be understood by assuming that the limiting extrusion mechanism is the nucleation of a vapor bubble inside the pores. A comparison of calculated and experimental nucleation pressures shows that a proper inclusion of line tension effects is necessary to account for the observed values of nucleation barriers. Negative line tensions of order 10(-11) J m(-1) are found for our system, in reasonable agreement with other experimental estimates of this quantity.

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PubMed2001

Phase separation in a chaotic flow.

The phase separation between two immiscible liquids advected by a bidimensional velocity field is investigated numerically by solving the corresponding Cahn-Hilliard equation. We study how the spinodal decomposition process depends on the presence-or absence-of Lagrangian chaos. A fully chaotic flow, in particular, limits the growth of domains, and for unequal volume fractions of the liquids, a characteristic exponential distribution of droplet sizes is obtained. The limiting domain size results from a balance between chaotic mixing and spinodal decomposition, measured in terms of Lyapunov exponent and diffusivity constant, respectively.

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PubMed2000

Fluctuation-dissipation relation in a sheared fluid.

In a fluid out of equilibrium, the fluctuation-dissipation theorem (FDT) is usually violated. Using molecular dynamics simulations, we study in detail the relationship between correlation and response functions in a fluid driven into a stationary nonequilibrium state. Both the high temperature fluid state and the low temperature glassy state are investigated. In the glassy state, the violation of the FDT is similar to the one observed previously in an aging system in the absence of external drive. In the fluid state, violations of the FDT appear only when the fluid is driven beyond the linear response regime, and are then similar to those observed in the glassy state. These results are consistent with the picture obtained earlier from theoretical studies of driven mean-field disordered models, confirming the similarity between these models and simple glassy systems.

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PubMed2000

Dynamic ultrametricity in spin glasses.

We investigate the dynamics of spin glasses from the "rheological" point of view, in which aging is suppressed by the action of small, nonconservative forces. The different features can be expressed in terms of the scaling of relaxation times with the magnitude of the driving force, which plays the role of the critical parameter. Stated in these terms, ultrametricity loses much of its mystery and can be checked rather easily. This approach also seems a natural starting point to investigate what would be the real-space structures underlying the hierarchy of time scales. We study in detail the appearance of this many-scale behavior in a mean-field model, in which dynamic ultrametricity is clearly present. A similar analysis is performed on numerical results obtained for a three-dimensional spin glass: In that case, our results are compatible with either that dynamic ultrametricity is absent or that it develops so slowly that even in experimental time-windows it is still hardly observable.

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PubMed1989

[Value of the isoprenaline test in arrhythmogenic heart diseases].

The sympathetic nervous system seems to play a major role in the genesis of ventricular arrhythmias. The authors studied this adrenergic factor prospectively by exercise stress testing and intravenous isoprenaline in 107 patients referred for evaluation of arrhythmias or symptoms thought to be due to arrhythmias: 30 patients had morphologically normal hearts (15 ventricular extrasystoles, 15 bursts of ventricular tachycardia); 55 patients had dilated cardiomyopathy and 22 had probable or proven arrhythmogenic right ventricular dysplasia. Exercise testing was carried out with 30 watt increments every 3 minutes. Ventricular tachycardia was induced in 6 patients with apparently normal hearts (17%), 13 patients with dilated cardiomyopathy (31%) and 7 patients with arrhythmogenic right ventricular dysplasia (40%). Isoprenaline was infused for 3 minutes at a dose of 8-12 g/min: ventricular tachycardia was induced in 7 patients with apparently normal hearts (24%) and 23 patients with dilated cardiomyopathy. In some patients presenting with syncope, an arrhythmogenic response to isoprenaline was the only abnormality detected by the study protocol. An arrhythmia was induced by isoprenaline in 17 of the 18 patients with confirmed right ventricular dysplasia (94%), 12 of whom had sustained mono or polymorphic ventricular tachycardia. Two of these patients did not have significant right ventricular wall motion abnormalities. Four asymptomatic subjects related to patients with right ventricular dysplasia underwent the isoprenaline test; bursts of ventricular tachycardia were recorded in 3 of them. Polymorphic ventricular tachycardia was specifically associated with cardiac disease. The maximum heart rate attained by exercise testing (148 +/- 19/min) was higher than that attained with isoprenaline (148 +/- 22/min).(ABSTRACT TRUNCATED AT 250 WORDS)

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