[Action of sublingual nifedipine on left ventricular filling in hypertensive crisis].
UNLABELLED: We studied the left ventricular filling before and 15 minutes after sublingual absorption of one Nifedipine capsule in 33 untreated hypertensive patients (mean age: 68.6) without other cardiac disease and presenting an hypertensive access. This study was carried out with Doppler-echocardiography. Sample volume was set at the tips of mitral leaflets. The protocol included: early peak filling velocity (VE), atrial peak velocity (VA), mitral pressure half-time (T1/2), isovolumic relaxation time (TRIV), velocity time integral of total mitral curve (VTIT) and velocity time integral of atrial curve (VTIA). We also studied VE/VTIT ratio which has been correlated to peak filling rate/mitral stroke volume ratio in radionuclide angiography. RESULTS: [table: see text] The variations of VA/VE, VTIA/VTIT, VE/VTIT and T1/2 are statistically significant but decrease of TRIV is not significant. The arterial blood pressure decreases from 184/103 to 153/83 and cardiac rate increases from 81.8 to 87.9 beats/minute. CONCLUSION: On hypertensive emergencies sublingual nifedipine significantly improves rapid left ventricular filling without change of TRIV. Acceleration of cardiac rate is moderate.