Activity of 3beta-hydroxy-delta5-steroid dehydrogenase/delta5-delta4-isomerase in the ovine corpus luteum.
Explore the source record for details and available documents.
3-Hydroxysteroid Dehydrogenases↗
Biomedical subjects
J L Caffrey
Publications and source records attributed to J L Caffrey.
The activity of ovine luteal cholesterol esterase during several experimental conditions.
Explore the source record for details and available documents.
Animals↗
Catecholamine-induced stimulation of progesterone and adenosine 3',5'-monophosphate production by dispersed ovine luteal cells.
Explore the source record for details and available documents.
Animals↗
A simple method for preparing suspensions of luteal cells.
Explore the source record for details and available documents.
Animals↗
Role of adrenal 5alpha-reductase activity in determining the responsiveness of hypophysectomized rats to ACTH.
Studies were conducted to examine the contribution of adrenal 5alpha-reductase to the phenomenon of diminished adrenal "responsiveness" to ACTH after hypophysectomy in rats. Rats hypophysectomized for 1 week secreted small amounts of corticosterone (B), 5alpha-dihydrocorticosterone (DHB) and 3beta,5alpha-tetrahydrocorticosterone (R) acutely after ACTH. Adrenal reductase activity in vitro at that time was high. After replacement with ACTH for 24 h, B,DBH, and R secretion increased slightly. Reductase activity remained high. Treatment with ACTH for 2 days further stimulated secretion of DHB and R but not B. Reductase activity was unaffected. Enzyme activity declined at 3 days concomitant with a proportionately greater increase in B than DHB and R secretion. Only after 7 days of ACTH did B secretion exceed DHB and R output. At that time, reductase activity was still lower. The results establish the functional significance of 5alpha-reductase activity as a regulatory site for the action of ACTH in determining the composition of adrenocortical secretory products in hypophysectomized rats.
Adrenal Glands↗
Modulation of the uptake and retention of estradiol-17beta in the ovine corpus luteum by luteinizing hormone.
The uptake and retention of 3H-estradiol by the ovine corpus luteum (induced by superovulation) was maximal through days 8-12 of the cycle with little or no uptake and retention during luteinization or regression. LH, but not FSH or prolactin, inhibited the uptake and retention of estradiol via stimulation of progesterone synthesis.
Aminoglutethimide↗
Effects of hypophysectomy and ACTH on adrenocortical function in the rat.
Explore the source record for details and available documents.
Adrenal Glands↗
Interaction of growth hormone and ACTH in the regulation of adrenocortical secretion in rats.
Explore the source record for details and available documents.
Adrenal Glands↗
Effects of steroid suppression and gonadectomy on adrenal 5alpha-reductase activity and corticosterone production in rats.
Explore the source record for details and available documents.
Adrenal Cortex Hormones↗