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J L Case

Publications and source records attributed to J L Case.

5 recordsLinked to original sources
PubMed1990

A comparative acoustic analysis of the Laugh responses of 20- and 70-year-old males.

Several studies have documented age-related changes in speech or voice characteristics, but no study has reported differences across age groups in human laughter. The purpose of this investigation was to identify, describe, and compare the measurements of five acoustic correlates of elicited, spontaneous laughter in twenty- and seventy-year-old males. Five acoustic characteristics of laugh responses including Initial Laugh Fundamental Frequency (ILFo), Mean Laugh Fundamental Frequency (MLFo), Peak Laugh Fundamental Frequency (PLFo), Duration Laugh Response (DLR), and Laugh Bursts (LB) as well as Speech Fundamental Frequency (SFF) were analyzed across groups. Statistically significant differences were found between twenty- and seventy-year-old males in ILFo, MLFo, PLFo, and in the number of laughs per minute. Older respondents produced a relatively compressed fundamental frequency range of laugh behavior and fewer laugh responses per minute. These differences are congruent with age-related changes in speech and voice but also might be explained by other physiological or sociological variables.

Acoustics↗
PubMed1985

Clearance of intravitreal 3H-fluorouracil.

The clearance of intravitreally administered 5-fluorouracil (5-FU) was studied under five experimental conditions. The same nontoxic dose resulted in similar initial intravitreal concentrations and cleared rapidly from all eyes (approximately 90% clearance within eight hours). Half-life values ranged from 46 to 168 minutes. The longest half-life occurred in aphakic-vitrectomized eyes in which hyaluronic acid (Healon) was substituted for vitreous (168 minutes). A similar half-life was found in normal eyes (150 minutes). The shortest half-life occurred in aphakic-vitrectomized eyes postoperatively (46 minutes). Intermediate half-life values occurred in vitrectomized but phakic eyes postoperatively (67 minutes) and in aphakic-vitrectomized "quiet" eyes (at least two weeks postoperatively) (82 minutes).

Animals↗
PubMedDate not supplied

Auditory dysfunction caused by multiple sclerosis: detection with MR imaging.

We reviewed the MR examinations of 167 patients who presented over a 3-year period with a chief symptom of hearing loss and/or tinnitus. In 14 of these patients the only MR abnormality was the presence of multiple parenchymal high-signal foci on T2-weighted images. Nine of the 14 had clinical evidence of multiple sclerosis; the remaining five had no clinical evidence of multiple sclerosis. Lesions in the auditory pathways, potentially responsible for the patients' symptoms, were identified in only five cases. We recommend T2-weighted images of the whole brain in addition to T1-weighted images of the internal auditory canals and cerebellopontine angles in patients with hearing loss. In some patients, lesions found at higher levels in the periventricular white matter may provide the only clue to the origin of auditory abnormalities.

Adult↗