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Biomedical subjects

J L Chabanais

Publications and source records attributed to J L Chabanais.

12 recordsLinked to original sources
PubMed1978

[Contusion and permeability of the hemato-aqueous barrier to fluorescein. Effect of a pretreatment by local indometacine (author's transl].

An experimental study, by angiography of the anterior segment of rabbit's eye, estimates the permeability of the hemato-aqueous barrier, using fluorescein. A trauma of the eye (contusion) leads to a rapid and significant increase in this permeability. However, local pretreatment, using an ophthalmic solution of 0,33% indometacine, almost completely stabilizes the hemato-aqueous barrier, even for elements as diffusible as fluorescein. These results suggest that application of a similar preparation to the human eye could be useful in the treatment of ocular contusions, chemical burns and angle-closure glaucoma. But the best perspective could be the application of the indometacine solution to the eye, before an operation, to reduce the sideeffects of surgery relative to the surgical break of the hemato-aqueous barrier.

Animals↗
PubMed1976

[Local indomethacin and early postcontusive ocular reaction in rabbits].

The local administration of a solution of indomethacin into the conjunctival fornix of the rabbit eye before anterior segment contusion has a marked inhibition on early post-contusion hypertonia. This result strongly suggests that local indomethacin could be of value in the treatment of accidental trauma to the eye as well as in the prevention of reactions following surgical trauma.

Administration, Topical↗