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Biomedical subjects

J L Curry

Publications and source records attributed to J L Curry.

At least 19 recordsLinked to original sources

Spontaneous dissection of internal carotid arteries. Spontaneous resolution documented by serial ocular pneumoplethysmography and angiography.

Spontaneous dissection of the internal carotid artery can appear on an angiogram as a total occlusion of this vessel. This appearance differs from that typical of atherothrombotic occlusion. In four patients with spontaneous dissections of internal carotid arteries, serial ocular pneumoplethysmography demonstrated spontaneous restoration to functional patency. Repeated angiography confirmed the noninvasive testing in all four patients.

Carotid Artery Diseases

Cellular immunity to cytomegalovirus in a patient following bone marrow transplantation.

Cell-mediated immunity to cytomegalovirus (CMV) was studied in a bone marrow transplant patient with evidence of active CMV infection. The lymphocytes from this patient were found to specifically recognize and respond in vitro by transformation to CMV-infected Wistar-38 fibroblasts and by production of macrophage migration inhibition factor to CMV antigen. In addition, plasma and spinal fluid from the patient were found to contain blocking factor that specifically inhibited the lymphocyte response in the above assays. Biochemical, biophysical, and immunological studies indicate that the blocking factor may be an antigen-antibody complex.

Adolescent

Thorium induced hepatic hemangioendothelioma. Roentgen-angiographic findings in two additional cases with clinical "inform and consent" problems.

1. Two additional cases of presumed, thorium-induced hemangioendothelioma of the liver are reported. 2. The angiographic pattern of large venous lakes conforms closely to the pathologic descriitions of this malignancy. 3. To our knowledge, angiography of the thorotrast (and vinyl chloride) liver, before the clinical evolution of malignancy, has not been recorded and may provide information of prognostic and therapeutic value. 4. Incidental identification of thorium deposits in the tissues of clinically healthy patients creates perplexing "inform and consent" problems. Presumably, these must be solved on an individual basis. 5. Because the use of thorotrast has been discontinued since the early 1950s, all physicians reviewing chest and abdominal roentgenograms should be aware of the characteristic appearance of human thorotrast deposits, especially in the liver, spleen and celiac lymph nodes. 6. The number of living thorotrast "carriers" and previous deaths from thorotrast related malignancy seems highly uncertain at this time.

Autopsy