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Biomedical subjects

J L Debru

Publications and source records attributed to J L Debru.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Data on the echocardiogram, pressure profile during exertion, and ambulatory blood pressure measurements in borderline arterial hypertension].

Comparative study is performed between echocardiographic measurements (TM), exercise test blood pressure profile (ETP) and ambulatory blood pressure load (BPL) in 26 borderline hypertensive subjects (19 males, 7 females). An abnormal ETP is found for 15 subjects (57 p. 100), an abnormal BPL for 10 subjects (38 p. 100). The diastolic interventricular septum thickness (IVS) and the diastolic posterior wall thickness (PWT) are abnormal (greater than 11 mm) for 6 and 3 subjects. Patient with pathologic ETP or/and BPL have greater IVS and PWT than other subjects (p less than 0,001). A good correlation is found between individual activity systolic blood pressure or 24 hours systolic blood pressure means values and PWT, IVS or left ventricular mass. These 3 examinations lead to a better assessment of cardiovascular strain and allow a better diagnosis and therapeutic approach in borderline hypertensive patients.

Adult↗
PubMed1983

Internuclear ophthalmoplegia in patients with toxic coma frequency, prognostic value, diagnostic significance.

Internuclear Ophthalmoplegia (INO), a dysfunction of the medial longitudinal fasciculus, is frequently seen in toxic coma (7 out of 70 cases). INO is most often bilateral and can be associated with different stages of coma. Such an association is a strong argument for the toxic etiology of a coma. But INO has no value in determining the source of intoxication and is no prognostic indicator for the outcome.

Adult↗
PubMed1983

[Ambulatory measurement of arterial pressure by a noninvasive procedure. Study of its variability in 18 normotensive subjects and 25 hypertensive patients. Research on criteria of normality].

Ambulatory blood pressure monitoring by an automatic non-invasive procedure allows the measurement of a large number of blood pressures and provides information in the variations of blood pressure during normal activity. The development of a programme on a minicomputer has helped simplify the expression of the results by: --a graphical representation of the evaluation of the blood pressure with respect to time (chronogramme); --a histogramme showing the distribution of the blood pressure values; --a representation of the pressure load with respect to time. By stocking the individual results a statistical study could be undertaken of the whole population. Eighteen normotensives, 15 borderline hypertensives and 12 permanent hypertensives were monitored for 24 hours. A circadien variation of blood pressure was observed in all three groups. Over an arbitrary chosen period (9 am-9 pm) the mean blood pressures and heart rates were: --Normotensives: SBP = 134 +/- 19; DBP = 79 +/- 11; HR = 79 +/- 14; --Borderline hypertensives: SBP = 151 +/- 30; DBP = 90 +/- 16; HR = 86 +/- 18; --Permanent hypertensives: SBP = 157 +/- 27; DBP = 102 +/- 17; HR = 83 +/- 17. An interpretation of these results requires information about the normality of the blood pressure levels during normal activities which remains to be studied. Resting values measured in the doctor's surgery need to be compared to ambulatory values in these three groups in order to judge the real significance of this method of measurement, and, in particular, to determine if the resting values are predictive of the blood pressure levels during activity.

Adult↗
PubMed1982

[Reproductibility of catecholamine and plasma renin activity values during exercise testing in normal subjects].

The authors studied the reproductibility of the measures of the haemodynamic (HR-SAP-DAP) and hormonal (PRA-plasma catecholamine) parameters at rest and during stress. 11 normotensive male subjects, age 20-26 years, have release 2 stress tests on ergometric bicycle spaced from 8 to 180 days (mean 54.2 days). The measure of haemodynamic parameters is reproducible during stress. The PRA measures is reproducible at stress instead of individual variations of natriuresis between 3-10 g. The measure of plasma norepinephrine levels is reproducible for strict rest and during stress. This express an identical participation of the sympathetic system for the same physical work load. This results express the interest of stress tests for the definition of a normal blood pressure and hormonal profile.

Adult↗
PubMed1982

[Changes in heart rate and blood pressure in a series of normotensive subjects before and after beta-blocker treatment (double-blind) during physical, dynamic, static and psychosensorial stress].

23 normotensive subjects in good health are submitted to a "test de l'exposé" and 17 others are submitted to a test on an ergometric bicycle and a hand grip stress test. These tests are performed twice at one week interval, with or without treatment with acebutolol, in double blind. HR,SBP and DBP are measured simultaneously before, during and after each test. Every stress is responsible for a marked increase in the parameters according to different modalities. With ACEBUTOLOL treatment, during the test described and during dynamic stress on ergometric bicycle, HR and SBP are always less elevated. The decreases are dependent either on the stress level or on the reactivity of the subjects. DBP is however basely modified. Under static stress, there is a decrease in HR, in SBP, but also in DBP; actually increase in this parameter is important during this type of stress.

Acebutolol↗
PubMed1982

[Value of the study of trigeminal nerve evoked potentials in chronic trichloroethylene poisoning. Preliminary results].

Results of a study concerning the trigeminal nerve impairment as the one caused by trichlorethylene chronic intoxication by somatosensory evoked potential reveal three kinds of anomalies: increase of the stimulation voltage, excessive latency delay with morphological anomalies and excessive graph amplitude. These anomalies confirm clinical disturbance (hypoesthesia in the trigeminal area) and open a debate about the real mechanism of the trichlorethylene neurotoxicity.

Adult↗
PubMed1981

[Automatic measure of arterial pressure using the oscillometric method (Dynamap 845)].

The reproducibility and reliability of measurements performed with an automatic blood pressure measuring device based on the oscillometric method were assessed by comparison with the results obtained by the indirect auscultation using a mercury manometer. The results of the mean values, of the correlation between successive values and of the variation of the values of systolic and diastolic blood pressure show that the readings obtained by the automatic method are very reproducible.

Adult↗
PubMed1981

[Data from a study of variations of arterial pressure during exercise in boys aged 11 to 16].

Systolic, diastolic BP and heart rate were measured in 106 boys aged between 11 and 16 years old, at rest and during exercise on a bicycle ergometer. The results show: -- at rest: an increase in systolic and diastolic BP with age, and a decrease in heart rate; -- during exercise: an increase in systolic BP without an increase, or with a decrease in diastolic BP. The blood pressure readings were higher in overweight and post pubertal subjects. The value of this study lies in the high number of reproducible readings obtained and in the suppression of the effects of emotivity. It completes the observations made at rest in subjects suspected of having hypertension.

Age Factors↗
PubMed1979

[Physiological variations of arterial pressure and heart rate in the first 5 minutes after moving from a supine to an upright position].

The physiological variations of blood pressure and heart rate were studied in the first five minutes of orthostatism in conditions identical to those encountered in clinical medicine. An increase in heart rate and diastolic blood pressure was observed from the first minute. The value of systolic blood pressure decreased as the subject got up and then rose to the value measured when lying down. At the fourth and fifth minute the three parameters were stable at significantly higher values than observed when lying down for the heart rate and diastolic blood pressure, but at an identical level for the systolic blood pressure. This study shows the necessity of measuring the orthostatic blood pressure using a precise technique which detects postural abnormalities when measured in the minute of orthostatism and which gives an assessment of the standing blood pressure when measured at the fifth minute.

Adult↗
PubMed1979

[Evaluation of an automatic device for arterial blood pressure determination : the Arteriosonde 1217].

The reproductibility and reliability of measurements made with an automatic device for measuring blood pressure was assessed with reference to the results obtained by indirect auscultation with a mercury manometer. The results of the study of the average values of the correlation between successive values, and of the variability of the values of the systolic and diastolic blood pressure show that the measurement obtained by this method are very reproducible.

Adult↗
PubMed1979

[Value of continous 12-hour electrocardiography during the rehabilitation period in patients convalescing from myocardial infarction. Apropos of 40 cases].

The results of continuous 12-hour electrocardiography in 40 convalescent patients after myocardial infarction undergoing a programme of readaptation on average 4 weeks after the initial infarction are reported. The frequency and alarming nature of the VES observed in 75% patients who had already undergone selection for the coronary readaptation programme, 30% of whom were receiving antiarrhythmic therapy, is emphasized. The observation of a progressive increase in the number of VES during the day prompts the following suggestions: the possibility of limited continuous ECG monitoring at the end of the day, the need to adapt the dosage of antiarrhythmic drugs during this most critical period. The comparison of the results of continuous ECG with those of repeated exercise ECG seems very positive, but some reservations are made and it would seem logical to associate these two complementary methods of investigation.

Adult↗