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Biomedical subjects

J L Doppman

Publications and source records attributed to J L Doppman.

At least 397 records · Page 22Linked to original sources
PubMed1975

Intrathyroidal parathyroid adenoma or hyperplasia. An occasionally overlooked cause of surgical failure in primary hyperparathyroidism.

In six surgically proved intrathyroidal parathyroid tumors, neither thyroid scan nor gross appearance of the thyroid at surgery allowed reliable detection of parathyroid glands wholly within the thyroid. Preoperative selective catheterization of thyroid veins with radioimmunoassay for parathyroid hormone facilitated successful removal of hyperfunctioning intrathyroidal parathyroid tissue in all five cases in which it was performed.

Adenoma↗
PubMed1975

Hypercalcitonemia in bronchogenic cancer. Evidence for thyroid origin of the hormone.

Retrograde venous catheterization in a hypercalcitonemic patient with adenocarcinoma of the lung demonstrated that the thyroid gland was secreting a very large amount of hormone (14-fold higher than the peripheral level), while the venous drainage from the tumor deposits was similar in concentration to that of the periphery. Conceivably, the calcitonin is being elaborated in response to metastatic and humoral bone resorption or both. Radiotherapy resulted in a decrease in the calcitonin level. Further studies are needed to determine the diagnostic or prognostic implications of serum calcitonin in bronchogenic cancer.

Calcitonin↗
PubMed1975

Localization of hyperfunctioning parathyroid tissue. Radioimmunoassay of parathyroid hormone on samples from the large veins of the neck and thorax and selectively catheterized thyroid veins.

Radioimmunoassay of parathyroid hormone on samples obtained from the large veins of the neck and thorax was utilized for localization in twenty-one patients with hyperparathyroidism. In seventeen of these patients, as many of the thyroid and mediastinal veins as possible were also sampled. This study reveals that sampling of the large veins of the neck and thorax is an insensitive means of adenoma from hyperplasia. Anatomic variations in the drainage of the inferior thyroid veins and dilution of the parathyroid venous effluent by the large veins of the neck and thorax seem to explain this insensitivity and the occasionally misleading results of large vein sampling. Sampling of the small thyroid veins, however, is a sensitive and specific means of localization and permitted preoperative differentiation of adenoma from hyperplasia in fourteen of our seventeen patients. Communications between the inferior thyroid and thymic veins and the fact that mediastinal adenomas frequently bring their blood supply down from the cerevical area suggest that sampling of the small thyroid veins may be of only limited value in identifying a mediastinal adenoma.

Adenoma↗
PubMed1975

Congenital pelvic arteriovenous fistulas: report of a case and review of the literature.

The fifth male patient with a congenital arteriovenous fistula of the pelvis is described. This disorder has been reported previously in 11 female patients. Most patients gave a long history of symptoms before a diagnosis was made. Preoperative angiography is vital to delineate the vascular supply to the fistula and operative treatment consists of ligation of the feeding vessels and resection of the fistula.

Hemangioma, Cavernous↗
PubMed1975

Atypical radiographic features in Pneumocystis carinii pneumonia.

The chest films in 30 proved cases of Pneumocystis carinii pneumonia were reviewed to determine the incidence of atypical radiographic findings. Seventeen of 30 patients or 56% presented at least one atypical radiographic finding during the course of the disease. Unilateral distribution, lobar involvement, abscess formation, fulminant progression, and atelectatic changes were observed in more than half the patients. A classic radiographic presentation, justifying treatment without biopsy, was seen in only 13 of the 30 patients.

Diagnosis, Differential↗
PubMed1975

The localization of abnormal mediastinal parathyroid glands.

The venous drainage of parathyroid glands ectopically located in the mediastinum is generally caraniad into the inferior thyroid veins. Parathyroid glands in the neck can cause elevated concentrations of parathyroid hormone in mediastinal veins because of thyroidalthymic anastomoses. Therefore venous sampling alone cannot distinguish cervical from mediastinal adenomas. Arteriography can localize mediastinal parathyroids and should be perfomred before any repeat exploration.

Adenoma↗
PubMed1975

Treatment of hyperparathyroidism by percutaneous embolization of a mediastinal adenoma.

Percutaneous embolization of parathyroid adenomas was attempted in three hypercalcemic patients with previously unsuccessful neck explorations. Two adenomas were in the mediastinum and the third was within the thyroid lobe. Autologous clot, Gelfoam, and silicone rubber were used to obstruct feeding arteries. The intrathyroidal adenoma failed to respond but both mediastinal adenomas were infarcted. Hyperparathyroidism recurred after 7 months in one patient but the other remains normocalcemic 8 months postembolization.

Adenoma↗