PubMed Health⌕ Search

Biomedical subjects

J L Elliott

Publications and source records attributed to J L Elliott.

44 records · Page 3Linked to original sources
PubMed1992

Presence of insulin-like growth factor-I receptors and absence of growth hormone receptors in the antler tip.

Red deer antler tips in the growing phase were removed 60 days after the recommencement of growth for autoradiographical studies and RRAs. Sections were incubated with radiolabeled GH or insulin-like growth factor-I (IGF-I), with or without excess competing unlabeled hormones, and were analyzed autoradiographically. There was negligible binding of [125I]GH in any histological zone of antler sections. [125I]IGF-I showed highest specific binding in the chondroblast zone to a receptor demonstrating binding characteristics of the type 1 IGF receptor. The lowest specific binding of [125I]IGF-I was to prechondroblasts. RRAs on antler microsomal membrane preparations RRAs on antler microsomal membrane preparations confirmed the absence of GH receptors and the presence of type 1 IGF receptors found by autoradiography. These findings suggest that IGF-I may act in an endocrine manner in antler growth through a receptor resembling the type 1 IGF receptor. The presence of type 1 receptors in the chondroblast zone implicates IGF-I involvement in cartilage formation through matrixogenesis. There is no support for IGF-I having a major role in mitosis in the antler.

Animals↗
PubMed1988

Swallowing disorders in the elderly: a guide to diagnosis and treatment.

Swallowing disorders are common in the elderly. They are most commonly seen in patients with cognitive-perceptual changes or neurologic deficits. The history and physical exam may be useful to increase your index of suspicion but cannot determine if a patient is at risk for aspiration. The modified barium swallow using videofluoroscopy is the most useful modality we have at this time for diagnosing swallowing disorders and determining appropriate interventions. Frequently, swallowing problems can be addressed with changes in dietary consistencies, by changes in positioning, or by techniques to improve oral control and sensitivity to food in the mouth.

Aged↗
PubMed1983

The acquired immunodeficiency syndrome and Mycobacterium avium-intracellulare bacteremia in a patient with hemophilia.

A 27-year-old previously healthy man with hemophilia presented with Pneumocystis carinii pneumonia. The patient had several episodes of oral candidiasis followed by disseminated infection with Mycobacterium avium-intracellulare. He was not homosexual nor did he take illicit drugs, but he had been self-administering two to four monthly infusions of factor VIII concentrate for 7 years. In-vitro lymphocyte studies showed findings consistent with the acquired immunodeficiency syndrome that had previously been reported only in homosexual men, drug addicts, and Haitian refugees. The cause of this syndrome is unknown, but the possibility that it is associated with a transmissible agent acquired through the use of blood products such as factor VIII concentrate must be considered.

Acquired Immunodeficiency Syndrome↗
PubMed1979

Methods for determining long-term survival in a population based study.

A 98.8% response rate was achieved in a follow-up study of a community based health survey. The follow-up methodology used in contacting the residents of 1700 households in a suburban upper-middle class community is presented. Study subjects, who were predominantly white, older adults, participated in the original health survey during 1972 and 1973. When the follow-up study was conducted three years later to determine the vital status of study participants, 30% of the households had moved. Follow-up response of two sets of mailings totaled 76.1%. An additional 12.1% response was obtained by calling residents at their last known address. The final 10.5% of the contacted households were located by intensive telephone tracing. A wide variety of sources of information, both local and non-local, were used to locate these "hard to trace" households. They were different from all other contacted households with respect to mobility rate, household size, and death rate. A 15.5% underestimate of the three-year death rate would have occurred if the hard to trace group had not been contacted. These results emphasize the importance of complete follow-up in prospective studies.

Adolescent↗