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Biomedical subjects

J L Eseverri

Publications and source records attributed to J L Eseverri.

At least 19 recordsLinked to original sources
PubMed1999

Parietaria allergy in children.

Parietaria, a grassy plant belonging to the Urticaceae family which is commonly found in urban environments, tends to grow on fences, walls and soils with a high content in nitrogen. Since 1983 the Xarxa Aerobiologica de Catalunya (Catalonian Aerobiological Network) has been using Hirst and Court sensors to monitor the daily concentrations of its pollen with respect to the weather conditions (wind, rain, temperature) in various sites in Catalonia and the Balearic Islands. This pollen is present practically all year round in our area, mainly during cold, rainy and seaside areas. Studies at a pediatric level are scarce and this is why we reviewed our data in this field. The study included a total of 12,650 case histories of first time attendances to our Pediatric Allergology Unit; 449 children showed sensitivity to Parietal pollen. Exclusive sensitivity to Parietaria in this age group of 1 and 15 years olds tended to be very low. However, we observed that after initial preferential sensitization to domestic allergens, Parietal pollen became the most frequent cause of sensitivity as the patients grew older. Although rhinoconjunctival manifestations predominate, at least at a pediatric level, the implication of Parietal pollen as a cause of bronchial asthma cannot be ignored.

Adolescent↗
PubMed1998

Allergy to pine nuts in children.

BACKGROUND: Allergy to nuts is a common and well-known disease. Despite the fact that pine nut is a widely eaten food, only nine cases have been described in literature. OBJECTIVE: To describe four paediatric patients suffering from allergy reaction on ingestion of pine nuts and compare them with cases described in literature, taking into account clinical symptoms, epidemiological and diagnostic methods. METHODS: The immuno-allergic study was carried out with skin tests (prick tests) using a commercial and native extract, and specific IgE serum test. An oral provocation test was performed in one case. RESULTS: Ages ranged from 12 months to 6 years. All patients had a personal history of atopy. Symptoms on ingesting pine nut were severe systemic reactions in three cases. Two of the children had allergic reactions to other nuts. In all cases, both the skin test and the specific IgE serum test were positive. The oral provocation was positive in the case for which it was performed. CONCLUSIONS: A typical clinical reaction of immediate hypersensitivity to this nut took place in all four children. The skin tests and in vitro studies confirm an IgE-mediated response. We currently have a commercial prick test for pine nut for the diagnosis, which has proven its sensitivity and specificity. In our region, due to the large consumption, the rate of allergic reactions to pine nuts would probably be greater and earlier on in life than in other areas.

Allergens↗
PubMed1996

Effect of conditions in obtaining blood samples for ECP testing in children.

Eosinophil Cationic Protein (ECP) is a basic protein found in eosinophil granules. This cell and its mediators are currently considered to be potential indicators of the severity of inflammation in the organism. ECP concentration can be reliably tested using several RIA or ELISA methods. It is well known that the conditions of sample obtention can affect the ECP values in blood. The aim of this study is to establish which parameters affect ECP testing during regular blood sample collection and how they affect it. Blood samples taken for the routine study of five children attended in our department were analysed: four were asthmatic and one child had atopic dermatitis. In the results we observed that ECP was not detected in the blood samples taken with EDTA tripotassium. In both the plasma samples taken with heparin as well as with serum, more ECP was released at a higher temperature. In the release of ECP obtained by coagulation, samples at 37 degrees showed values of between 4 and 20 higher than those obtained for an hour at 0 degrees. There is a considerable variability in the testing of ECP depending on the blood test extraction conditions, the range is bigger in the samples with eosinophils. These results imply the need to define a stricter protocol for obtaining samples than that suggested at present.

Adolescent↗
PubMed1996

[Ebastine : treatment of perennial rhinitis in the child].

Ebastine is H1 receptor antagonist, powerful and selective for histamine. Its efficacy has been evaluated in control of symptoms of persistent rhinitis, appearance of secondary effects and tolerance of the drug, in 30 children who were suffering from persistent rhinitis, of which the diagnosis included:- clinical history, skin tests (prick test) nasal and conjunctival provocation tests, total and specific IgE. All the children had treatment for 30 days. The parameters followed were:- clinical score, skin tests, nasal and conjunctival provocations and evaluation of secondary effects, of the start and 10 days after the end of treatment. The results obtained were a disappearance or reduction of the weals from histamine and specific antigens, disappearance or reduction of the response in nasal and conjunctival provocation with carbachol or specific antigens, clear clinical improvement in 22 patients, in 2 small improvement and no response in 6 patients. We conclude that Ebastine improved the clinical symptoms in persistent rhinitis, the skin test is inhibited and sensitivity of the shock organ is reduced. No secondary effects were seen on the Central Nervous System (SNC) and the tolerance of the drug was very good.

Adolescent↗
PubMed1995

Budesonide: treatment of bronchial asthma during childhood.

Nowadays inhaled corticosteroids are the first step in treating inflammation of the airways. It is evident that these drugs are not free of side effects; however, the fact that at present the most commonly used method is by inhalation and that these drugs undergo metabolic changes in the lung, makes them safe in that a part of the side effects, which are observed when they are administered systemically, disappear. Budesonide was one of the last corticosteroids for topical application to appear on the market and its powerful anti-inflammatory action together with in versatility (it can come in aerosol form using MDI or in solution for nebulizers as well as in dry powder) make it possible to use during all stages of a child's development. In 75 children treated with Budesonide over a long period (18-24 months) we were able to evaluate the drug's clinical efficacy in the reduction in number and intensity of attacks registered together with their accompanying symptoms. Significantly (p < 0.001) it were able to restrict the bronchodilatory medication needed to control their asthma. Similarly, we were able to verify that the FEV1 was normalized and that the Peack Flow was stabilized. We were not able to find any interruption in the hypothalamo-hypophysio-suprarenal axis and the weight-height curves continued to evolve chronologically. With regards to the side effects, three cases of colonization candidiasis were recorded through there were no clinical repercussions and treatment did not need to be suspended.

Administration, Inhalation↗
PubMed1993

Specific IgE antibodies in nasal secretions: correlation with serum values and clinical tests.

The presence of specific IgE in external secretions and the possibility of quantifying it has aroused the interest of many research workers. Nevertheless, there is still disagreement with regard to how useful this practice is from a clinical point of view. We have compared the presence of Dermatophagoides pteronyssinus (Dp) specific-IgE in the nasal secretion of 17 patients suffering from rhinitis with the results of prick tests and nasal and/or conjunctival challenge tests. As a preliminary step we have updated techniques and made a correlation between the parameters mentioned. The results for total IgE (n = 17) show a correlation coefficient (r = .39, NS) between serum values (251 +/- 239) U/L and those obtained in nasal secretion (28 +/- 36) U/L. (2) Serum and nasal-Dp-specific-IgE values (13 +/- 15 and 5 +/- 9, respectively: (r = .72, P = .0011) match in 14 of the 17 determinations. In two of them, the serum values of Dp-specific-IgE, but not the nasal ones, match the in vivo tests. In the others, it is the nasal secretion determination that matches the in vivo tests while the serum and nasal determinations match (82%). These results match in 86% of cases with prick tests and in 93% with nasal/conjunctival challenge tests.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1992

Mustard allergy. Two anaphylactic reactions to ingestion of mustard sauce.

Two cases of anaphylactic reactions set off by the ingestion of a small amount of mustard sauce are described. Mediation by specific IgE to mustard was determined by skin prick tests and radioimmunoassay, which suggested a type I hypersensitivity mechanism. Despite the antigenic potency of mustard, a spice that is consumed frequently, very few cases of hypersensitivity from ingestion have been described.

Adolescent↗
PubMed1991

Semiquantitative determination of serum IgE by reagent strips: PRIST/TOTALE correlation.

Due to its great simplicity, the determination of total and specific IgE with a reagent strip could be a screening method for in vitro allergy diagnosis if a correlation with classical techniques is verified. The TOTALE reagent strip for semiquantitative determination of total serum IgE is one of these methods and unites the now classical foundation (anti-IgE/IgE/anti-IgE labeled sandwich) and the ease of the reagent strip technique. In a preliminary evaluation of these methods we compared the PRIST isotopic method to the TOTALE one for serum total IgE. In summary, the most relevant consequences from this comparison are the following ones: a) The initial sample is the same for both: serum. b) No additional equipment or materials other than the serum sample are needed for TOTALE practising. c) The reagent strip has a lower cost and is faster than the PRIST method. d) Correlation coefficients were 0.89 (n = 35) in the range of measurement under study and 0.93 (n = 23) in the range from 5 to 200 U/L.

Child↗
PubMed1991

Asthma trough to Parietaria in pediatrics.

We selected 183 patients with asthma, rhinitis and/or conjunctivitis. They responded positively to Parietaria Judaica skin prick-tests. In the first test 91 were positive. Of those 11 were monosensitive and 80 polysensitive. In the follow-up tests 92 were positive, of which 5 were monosensitive and 87 polysensitive. There were 54 cases of rhinitis, of which 23 developed asthma. Of 129 asthma cases, 90 developed asthma with rhinitis. The main seasons are Spring and Autumn and activity declines during winter. 18.57% are perennial. IgE was greater in the re-examination of the polysensitive cases. The monosensative cases confirmed the clinical symptoms most characteristic of rhinitis syndrome, 16.893% and asthma with rhinitis, 49.18%.

Asthma↗
PubMed1988

Inducement test in cow's milk allergy.

Results of practical tests with whole milk and the three most allergenic proteins were compared in 32 children who were suspected of showing allergy to milk. Diagnosis was composed of a suggestive clinical history, familial atopy, positive in vitro and in vivo tests and regression of symptoms under an exclusion diet. Tests of re-introduction were done with 11 children. Better agreement between the provocation tests and the other elements of the diagnosis was found when the tests were made with the fractions, rather than whole milk. Furthermore, the finding of reduced allergy to casein allows consideration of re-introduction of milk in the form of cheese.

Administration, Oral↗
PubMed1984

Aspirin-induced recurrent urticaria and recurrent angioedema in non-atopic children.

Recurrent urticaria and recurrent angioedema are frequent adverse reactions in non-atopic patients who do not tolerate aspirin. Of 1,632 infants and children who visited our allergy department for the first time, nine children (0.55%), five males and four females, presented recurrent urticaria or recurrent angioedema after taking aspirin. No evidence of atopy was disclosed either by clinical history (personal and family), skin testing, eosinophil levels or total IgE. Aspirin intolerance was established by oral challenge. Only three of the nine patients reported aspirin intolerance in their histories.

Angioedema↗