PubMed Health⌕ Search

Biomedical subjects

J L Faure

Publications and source records attributed to J L Faure.

54 records · Page 3Linked to original sources
PubMed1987

[Endoscopic treatment of vesico-ureteral reflux].

Submucosal injection of Teflon for treatment of vesicoureteral reflux (the sting of O'Donnell) was used in 43 patients (66 ureters-21 bilateral cases). 14 patients were on dialysis and reflux was diagnosed at medical evaluation during pretransplantation work-up; correction of reflux was indicated as a preparation for renal transplantation. In another group of 24 patients with normal renal function reflux appeared as a simple congenital abnormality. 5 patients had reflux secondary to TUR or ureteral reimplantation. The procedure was performed under general or epidural anesthesia. Ultrasound examination of kidneys was performed 24 hours after the procedure, cystography and UIV was performed after 30, 100 days and one year. No ureteral obstruction were observed. In the first group of patients (on dialysis) correction of reflux was effective in 40% of cases. In the second group (congenital vesicoureteral reflux) correction was observed in 85% of cases (30/35 controlled cases). In the third group correction of reflux was observed in 83% of cases (5/6). Results in the first group of patients may be due to technical difficulties while injecting of Teflon in small, thickened sclerotic bladders. Though longterm results are still to be evaluated. The sting may be beneficial in patients on dialysis waiting for a renal transplant as it obviates the need for bilateral nephrectomy. In simple congenital reflux short and middle term results are excellent.

Adult↗
PubMedDate not supplied

Clinical experience in pancreas transplantation in Lyon: long-term survival of duct injected pancreatic grafts.

Ninety-seven pancreatic grafts in 92 insulin-dependent diabetic patients were performed during the last 11 years. Eighty-three of these grafts were carried out after neoprene duct injection, the other patients underwent pancreato-duodenal transplantation. In 80 cases, a double pancreas and kidney graft was performed. Five different immunosuppressive protocols were subsequently applied. Actuarial survival of patients and pancreata was 75.1% and 47%, after one year and 54.6% and 22.1%, respectively, 4 years after transplantation. Slightly better results were observed in double pancreas and kidney transplantation. The survival of both patients and pancreas improved when the most recent immunosuppressive protocols including cyclosporin A and only small doses of steroids were applied. The main causes of loss of the pancreatic graft were rejection, vascular thrombosis and death of the patient with functioning organ. Metabolic studies showed good insulin secretion with normal or impaired glucose tolerance as well as good short and half-term glycemic control. Whole pancreas grafts with enteric diversion yielded prompter and higher insulin secretion but the incidence of surgical complications was increased. In comparison to the data recorded at 6 months after pancreas transplantation, 5 patients of our series with still functioning organ showed an equally satisfactory and unchanged glycemic control after more than 4 years from surgery. In these patients, the previously high insulinemic values decreased to normal levels. However, 3 of these patients showed a decrease in post-prandial peaks as confirmed also by OGTT. However, mean blood glucose level was not altered. In our series the suppression of exocrine pancreatic secretion by neoprene duct injection did not appear to represent a relevant cause of decrease in endocrine function. The results obtained do not yet allow us to draw definite conclusions as to the efficacy of pancreas transplantation in the treatment of degenerative complications in diabetic patients.

Adult↗