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Biomedical subjects

J L Fonseca

Publications and source records attributed to J L Fonseca.

11 recordsLinked to original sources
PubMed1992

Malignant fibrous histiocytoma of the aorta complicated by anuria.

Tumors of the aorta have been reported infrequently in the literature. We report a case of a 63-year-old woman diagnosed with malignant aortic fibrous histiocytoma (also known as fibroxanthosarcoma). She was referred to us with suspected occlusion of the right renal artery in a single functioning kidney, with a clinical picture of anuria during the previous 48 hours. We also review 31 previously published cases in the literature.

Anuria↗
PubMed1987

Aesthetic reduction of the upper lip.

The upper lip, given its surface anatomy and morphology, should be no more than 2 cm high. Therefore, to reduce the upper lip we propose an incision at its highest portion similar to the letter M which extends into the nasal vestibula. We aim at a real reduction of the height of the lip as well as restoration of its natural concavity through a scar situated obscurely, and which tends to disappear within a few months postoperatively. In patients in whom the upper lip is less than 2 cm high but the vermilion is minimal, we use Gillies' technique and make curvilinear incisions. We have also observed correction of the perioral wrinkles using this technique.

Humans↗
PubMed1983

Use of pericranial flap in scalp wounds with exposed bone.

We present two cases of traumatic loss of portions of the scalp, one by electrical burn and the other by avulsion. Both patients had large areas of osseous exposure, in which we made use of pericranial flaps taken from the back half of the skull in order to cover the exposed bone. At the same time, local flaps were made and skin grafted over the pericranial flap in a single surgical step using the usual surgical procedures.

Adult↗
PubMedDate not supplied

Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi.

Accidental transmission of Chagas' disease to man by blood transfusion is a serious problem in Latin-America. This paper describes the testing of several synthetic, semi-synthetic, and natural compounds for their activity against blood trypomastigotes in vitro at 4 degrees C. The compounds embody several types of chemical structures: benzoquinone, naphthoquinone, anthracenequinone, phenanthrenequinone, imidazole, piperazine, quinoline, xanthene, and simple benzenic and naphthalenic derivatives. Some of them are for the first time tested against Trypanosoma cruzi. The toxic effect of these compounds on this parasite was done by two quite distinct sets of experiments. In one set, the compounds were added to infected blood as ethanolic solution. In this situation the most active one was a furan-1,2-naphthoquinone, in the same range as gentian violet, a new fact to be considered in the assessment of structure-activity relationships in this class of compounds. In other set, we tentatively evaluated the biological activity of water insoluble compounds by adding them in a pure form without solvent into infected blood. In this way some appear to be very active and it was postulated that the effectiveness of such compounds must result from interactions between them and specific blood components.

Animals↗
PubMedDate not supplied

Direct surgery on the aorto-iliac area. Prostheses--endarterectomy?

Of the 365 surgical techniques performed on the aorto-iliac area in 354 patients, 448 extremities were revascularized by means of the insertion of a prosthesis as a by-pass, and 165 by thromboendarterectomy (TEA), either global or ilio-femoral. The patency rate at five years was 83% for prostheses, and 72% for TEAs, studied as a whole, or 75% for global TEAs, and 60% for ilio-femoral, once they had been individually analysed. The analysis of these results proves that the patency of the ravascularized aorto-iliac area depends more on the associated pathology in the femoro-popliteal distal area, than on the surgical technique that has been applied. There are no significant differences in relation to the early patency or mortality between the three groups, although as regards age, younger patients with fewer risk factors were selected for global TEA operations.

Aorta, Abdominal↗