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Biomedical subjects

J L Goldman

Publications and source records attributed to J L Goldman.

14 recordsLinked to original sources

Subglottic tuberculosis: a case report.

Granulomatous disorders of the larynx can take on many forms and usually represent the end stage of chronic disease. In the past, laryngeal granulomas were much more prevalent primarily because of the frequency of tuberculosis. Seldom is the larynx the site of origin for granulomatous disease, but it is usually a manifestation of a pulmonary entity such as histoplasmosis, blastomycosis, sarcoidosis, or tuberculosis. The actual diagnosis is frequently arrived at while trying to rule out carcinoma. Laryngeal tuberculosis, although rare in the United States, remains the most common granulomatous disease of the larynx. Its increasing incidence has paralleled the diminished incidence of tuberculosis in the general population. Specific clinical characteristics for diagnosis are few and diagnosis is arrived at through a high index of suspicion and biopsy. When biopsy is carried out, adequate tissue should be obtained for both histological sections, cultures, and sensitivities.

Aged

Indirect laryngoscopy.

Indirect laryngoscopy is one of the procedural methods used for achieving a histopathologic diagnosis of cancer of the larynx. A chronologic historical summary of the development of mirror laryngoscopy is presented. The details of the procedure employed for obtaining a biopsy with the aid of topical anesthesia is discussed.

Anesthesia, Intravenous

Combined pre-operative irradiation and surgery for advanced cancer of the larynx and laryngopharynx. (A 14 year correlative statistical and histopathological study).

A carefully planned clinical program of combined pre-operative radiation and surgery has been conducted by the Department of Otolaryngology at The Mount Sinai Hospital for 14 years in an effort to improve the survival rate for advanced cancer of the larynx and laryngopharynx. An extensive histopathological study of resected larynges and radical neck specimens was undertaken in 1961 in order to determine the effects of pre-operative radiation. A very careful statistical analysis has been made of the survival experience of this series of cases. The three and five year survival rates have been computed by the actuarial method. The histopathological study entailed a serial section study of 26 larynges and 21 radical neck dissection specimens. These studies have been most informative as to the nature of the radiobiologic process involved in the destruction of laryngeal cancer. In addition, the study has been revealing as to the ability of radiation to sterilize cancer in the neck specimens. The clinical correlate of this histologic finding has been the observation of reduced cervical recurrences in patients treated with combined therapy. In conclusion, our statistics seem to indicate that our combined therapy method has improved the survival rates of patients with advanced cancer of the larynx and laryngopharynx.

Evaluation Studies as Topic

Cyclic pharyngeal lymphoiditis: immunological considerations.

This communication presents the concept that recurrent infections of the lingual tonsils, lateral pharyngeal lymphoid bands and lymphoid follicles on the posterior pharyngeal wall, occurring with the same periodicity, is a cyclic clinical and immunological entity. These patients lacked resistance to the normal flora of the nasopharynx and pharynx. They were accordingly treated with a mixed respiratory bacterial vaccine, administered intradermally and according to a formulated program, to improve resistance or immunity of the lymphoid tissue. These patients showed definite improvement by this method of therapy. It is suggested that the effectiveness of therapy was accomplished through the immunological process of cell-mediated immunity. The immunobiologic development of cell-mediated immunity by T thymic-dependent cells and humoral immunity by B cells is briefly discussed.

Animals