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Biomedical subjects

J L Gupta

Publications and source records attributed to J L Gupta.

9 recordsLinked to original sources
PubMed1982

Epidemiology of burns in children.

This chapter deals with the magnitude of the problem of burns in a developing country and describes the epidemiology. The common causes of burn injury have been illustrated by suitable photographs. The author feels that a large percentage of both domestic and industrial burns are preventable by simple modification of the agents or environment, and by public education. He recommends that public, social workers, professional persons, industrialists, government and nongovernment agencies undertake a programme for prevention of such accidents.

Burns↗
PubMed1980

Controlled trial of Pseudomonas immunoglobulin and vaccine in burn patients.

In a controlled trial burn patients at risk of Pseudomonas aeruginosa septicaemia were passively immunised with an immunoglobulin prepared from plasma from healthy human volunteers vaccinated with a polyvalent pseudomonas vaccine; passively immunised and vaccinated; or only vaccinated. In children the mortality was lowest in those passively immunised (0%, 0/18); it was 21% (9/42) in controls. In adults the mortality rate of those receiving immunoglobulin or vaccine was 10% (3/30) or 8.3% (5/60), respectively, compared with 36% (22/61) in controls. Combined vaccine and immunoglobulin treatment gave rather less protection (mortality 13.6%, 3/22) than vaccine alone. Pseudomonas infection of burns was less common in patients who received immunoglobulin than in vaccinated or control patients.

Adolescent↗
PubMed1979

Controlled trials of a polyvalent pseudomonas vaccine in burns.

A polyvalent pseudomonas vaccine has been tested in controlled clinical trials at two burns units, in Birmingham and New Delhi, in children and adults with burns more than 15% full skin thickness. None of the vaccinated patients in either trial showed blood cultures containing Pseudomonas aeruginosa, and vaccinees showed raised titres of protective antibody and increased phagocytic activity against Ps. aeruginosa. In the New Delhi unit, where death from Ps. aeruginosa infection is common, the mortality in adults was reduced from 40.6% (13/32) in the unvaccinated group to 6.6% (2/30) in the vaccinated group, and in children from 20.8% (5/24) in the unvaccinated group to 4.8% (1/21) in the vaccinated group.

Adolescent↗