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Biomedical subjects

J L HARKINS

Publications and source records attributed to J L HARKINS.

6 recordsLinked to original sources
PubMed1964

CLINICAL AND LABORATORY ASSESSMENT OF A NEW PROGESTATIONAL AGENT.

Studies of the effects of megestrol (6-methyl, 6-dehydro, 17alpha-acetoxy progesterone) on human subjects indicated that this drug is a potent, orally effective progestational agent. The progestational effect was enhanced by estrogen. When combined with ethinyl estradiol satisfactory control of menstrual function and inhibition of ovulation were achieved. Increasing doses of this combination were effective in four patients with endometriosis. Side effects of the drug were minimal. No toxic effects on adrenal, hepatic or hematopoietic function were noted.

17-Ketosteroids↗
PubMed1964

A CLINICAL EVALUATION OF INTRAVENOUS DIMENHYDRINATE IN LABOUR.

Dimenhydrinate was administered intravenously to patients in spontaneous labour in order to evaluate its effect on the length of labour, its analgesic property, its potentiation of the effects of standard analgesics and its overall safety. The results of this study provided no evidence that labour was shortened or that uterine activity was increased in those receiving intravenous dimenhydrinate, nor did this drug decrease the need for conventional analgesics. There were no maternal or fetal complications. It is concluded that intravenous administration of dimenhydrinate has no advantage over analgesics administered by other routes and has a limited use in current obstetrical practice.

Administration, Intravenous↗