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Biomedical subjects

J L Hansen

Publications and source records attributed to J L Hansen.

80 records · Page 5Linked to original sources
PubMedDate not supplied

A scanning-slit x-ray videoabsorptiometric technique for bone mineral measurement.

An x-ray videoabsorptiometric technique was developed for measurement of bone mineral content (BMC) in vivo. The principle utility of this technique is the precise measurement of commonly fractured bones, such as the femoral neck, that are difficult to measure by other techniques because of repositioning problems. Scanning slits reduce scattered radiation and improve linearity of measurements. Heavily filtered, high-kVp beams are used to minimize errors from beam hardening, and data renormalization is employed to compensate for spatial nonuniformities of the beam and detector. Linearity of measured BMC over the range 0.8 to 5 g/cm2 is very good (r = 0.998) and compares well to single- and dual-photon absorptiometry. A 1.6% change in measured BMC is observed for a 10% change (approximately 2 cm) in tissue thickness while a 10% change in marrow type causes a 0.6%-0.8% change in BMC. Manual repositioning of a femur phantom revealed a variation of 0.84% over ten measurements when femur values were referenced to standards. A computer repositioning algorithm provides much easier identification of the region for analysis and yields comparable variation (0.9%).

Aged↗
PubMedDate not supplied

The influence of ionization chamber and phantom design on the measurement of lung dose in photon beams.

Lung dose correction factors, commonly defined as the ratios of ionization chamber readings in the heterogeneous and homogeneous phantoms, have been compared with those based on accurately determined doses. An analysis of stopping power values, Pwall values, and measurements in lunglike and waterlike materials showed that the wall material and thickness are not very critical in the determination of lung dose correction factors under conditions of electronic equilibrium. When lateral electronic equilibrium is not established due to the extended range of scattered electrons in the low density material, Prepl differs significantly from unity for ionization chambers with thick walls which do not match the lung material in density. An attempt has been made to characterize this effect as a function of photon energy, lung density, field size, and wall thickness.

Humans↗
PubMedDate not supplied

Pilot study of local hyperthermia, radiation therapy, etanidazole, and cisplatin for advanced superficial tumours.

Five patients (six hyperthermia sites) with advanced superficial tumours were treated with combined etanidazole, cisplatin, local hyperthermia, and radiation therapy as part of a Phase I pilot study. Treatment was given once weekly and consisted of etanidazole 3 gm/m2 IV bolus, cisplatin 50 mg/m2 IV bolus, hyperthermia for 60 min with a target temperature of 43 degrees C, and radiation therapy 500 cGy/fraction (median total dose 3000 cGy) for a total of six weeks. Blood levels of etanidazole were taken during treatment at week 1 and week 4. Etanidazole drug exposure was calculated using the trapezoidal rule and expressed as the area under the curve (AUC) of plasma concentration x time. Five of six treatment sites had received prior irradiation. Prior chemotherapy had been given in three patients and tamoxifen therapy given in the other two patients. The median follow-up time is 34 months; 3/5 patients have died of disease. The most significant toxicity was grade I or II nausea and vomiting associated with 19/32 treatments (59%) and a second degree burn in 2/6 fields. None of the five patients experienced peripheral neuropathy, skin ulceration, or needed surgical repair. In addition, there was mild renal toxicity; pharmacokinetic analysis showed a 28-75% increase in the week 1 to week 4 AUC in three patients, all of whom had a decrease in creatinine clearance over the same time of 15-47%. This pilot study suggests this combined modality therapy can be delivered without major complications and that renal function, determined by creatinine clearance, affects clearance of etanidazole and alters the AUC. Therefore, monitoring renal function is important in patients receiving etanidazole in addition to other nephrotoxic agents such as cisplatin. The impact of etanidazole on the therapeutic index of hyperthermia, radiation therapy and cisplatin may be worth of study, especially since a positive interaction between these modalities is found in laboratory models.

Adult↗
PubMedDate not supplied

Design of an ultrasonic therapy system for breast cancer treatment.

This paper describes the design of a novel ultrasonic therapy system dedicated to the breast cancer treatment and the theoretical investigation of the heating characteristics of the system. The applicator is a cylinder comprised of a stack of rings. Each ring has up to 48 transducers mounted on the inside of the ring and directed towards the centre. The transducers operate in one of two frequency bands (1.8-2.8 MHz and 4.3-40.8 MHz), arranged alternately in each ring. During treatment the patient is positioned in prone position, with the breast immersed in water and surrounded by this array. This design was modelled and optimized by 3-D simulations for a variety of treatment conditions. The simulated results demonstrate that the system has an excellent capability to achieve and maintain a temperature distribution (41.5-44 degrees C) in a quadrant to a whole breast. Initial experiments using a single ring of transducers has been performed to verify the power deposition calculation.

Breast Neoplasms↗
PubMedDate not supplied

Regulation of the onset of meiosis in the developing testis.

Meiotic division begins the process of spermatogenic maturation leading to sperm formation. In contrast to the ovary, in which meiosis is initiated early in development, onset of meiosis in the testis is delayed until the time of puberty. An assay procedure was utilized to evaluate factors responsible for the activation and prevention of meiosis in the developing rabbit testis. Testicular specimens from postnatal rabbits at different ages were used to determine if meiosis-activating substance (MAS) activity and meiosis-preventing substance (MPS) activity could be demonstrated prior to the onset of spermatogenesis. An in vitro system in which undifferentiated gonads from 11.5 day old mouse fetuses are cultured in test and control media was employed. The findings indicate that MAS activity is associated with the onset of spermatogenesis and is also present shortly after birth. Activity of MPS is present throughout much of the prespermatogenic period, with a decline to reach low levels at the onset of spermatogenesis.

Animals↗