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Biomedical subjects

J L Harris

Publications and source records attributed to J L Harris.

At least 19 recordsLinked to original sources

Upward mobility for LPNs: a vision made reality.

A recurrent theme in the nursing literature is the shortage of realistic, long-term solutions directed toward registered nurse (RN) recruitment and retention. If fragmentation of RN recruitment and retention is to be eliminated, innovative programs involving collaboration and use of existing resources will be required. This article provides an overview of how collaboration among nurses, administrators, educators, and a personnel specialist resulted in an upward mobility program for licensed practical nurses (LPNs) to become RNs. While the program is specific to one setting, there are numerous implications for other hospitals confronted with persistent recruitment and retention problems.

Career Mobility

Sociologic aspects of pregnancy.

Increasingly, social factors are recognized as having a major impact on pregnancy, childbearing, and prenatal care. This review examines some of the more recent societal developments that have influenced health care for pregnant women. Although human gestation is a biologic phenomena, it exists with the social context of personal needs, family, and community of the pregnant women. This social fabric determines the perception, management, and outcome of that gestation. Significant influences to examine include pregnant women in the work force; malpractice concerns of health care providers; issues related to the cost of health care in pregnancy; the legal rights of the pregnant woman versus the legal rights of the fetus; pregnancy and occupational health; and the role of stress in pregnancy outcome.

Career Choice

Haptic asymmetries in persons with and without mental retardation.

Adults with mild mental retardation and equal-MA children and adults without mental retardation were required to (a) tactually examine single letters, two-letter words, bigrams, and Chinese characters with their right or left index finger and (b) indicate whether a visually presented stimulus was the tactually examined stimulus by saying "same" or "different." The left hand was significantly better for "same" responses and the right hand, for "different" responses, suggesting that hemispheric processing is dependent on information-processing requirements rather than type of stimulus. A left hand advantage for "same" Chinese characters by the children and adults without mental retardation was due to an increase in right hand latencies rather than a decrease in left hand latencies, again suggesting that different types of analyses are employed by the two cerebral hemispheres. Adults with mental retardation had the poorest accuracy and slowest latencies for correct "different" responses and significantly less differentiation of "same" and "different" responses (A') for all stimulus types. They identified "same" letters, words, and bigrams significantly faster than Chinese characters with their left hand and showed a trend toward the differential processing of bigrams ("same" latencies) as a function of hand.

Adult

Diabetes mellitus in pregnancy.

The Council on Scientific Affairs of the California Medical Association presents the following inventory of items of progress in obstetrics and gynecology. Each item, in the judgment of a panel of knowledgeable physicians, has recently become reasonably firmly established, both as to scientific fact and important clinical significance. The items are presented in simple epitome, and an authoritative reference, both to the item itself and to the subject as a whole, is generally given for those who may be unfamiliar with a particular item. The purpose is to assist busy practitioners, students, researchers, or scholars to stay abreast of these items of progress in obstetrics and gynecology that have recently achieved a substantial degree of authoritative acceptance, whether in their own field of special interest or another. The items of progress listed below were selected by the Advisory Panel to the Section on Obstetrics and Gynecology of the California Medical Association, and the summaries were prepared under its direction.

Diabetes, Gestational

Universal self-care requisites as identified by homeless elderly men.

1. Given the current economic climate, the number of homeless persons, and the nature of their needs, nurses must be prepared to facilitate movement of all homeless persons toward self-care. 2. Nurses can contribute to the self-care of homeless elderly men by recognizing and eliciting requisites, associated actions, and nursing interventions that reinforce meeting of needs. 3. Study results support Orem's proposition that universal self-care requisites are common to all individuals regardless of age, sex, developmental level, health state, or internal or external conditions. 4. A number of participant's statements used to formulate themes suggested a relationship to more than one category of universal self-care requisites, which suggests that the categories are not mutually exclusive.

Aged

Monoterpene biosynthesis: specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves.

Microsomal preparations from the epidermal oil glands of Mentha piperita, Mentha spicata, and Perilla frutescens leaves catalyze the NADPH- and O2-dependent allylic hydroxylation of the monoterpene olefin (-)-limonene at C-3, C-6, and C-7, respectively, to produce the corresponding alcohols, (-)-trans-isopiperitenol, (-)-trans-carveol, and (-)-perillyl alcohol. These transformations are the key steps in the biosynthesis of oxygenated monoterpenes in the respective species, and the responsible enzyme systems meet most of the established criteria for cytochrome P450-dependent mixed function oxygenases. The reactions catalyzed are completely regiospecific and, while exhibiting only a modest degree of enantioselectivity, are highly specific for limonene as substrate. Of numerous monoterpene olefins tested, including several positional isomers of limonene, only the 8,9-dihydro analog served as an alternate substrate for ring (C-3 and C-6) hydroxylation, but not side chain (C-7) hydroxylation. In addition to the regiospecificity of the allylic hydroxylation, these enzymes are also readily distinguishable based on differential inhibition by substituted imidazoles.

Cyclohexenes

Self-care actions of chronic schizophrenics associated with meeting solitude and social interaction requisites.

Solitude becomes a way of life and social interaction a scarce commodity for many chronic schizophrenics who are in institutional settings. This article describes the self-care actions associated with meeting solitude and social interaction requisites as reported by 10 institutionalized chronic schizophrenics. Eighteen solitude self-care actions and 10 social interaction self-care actions emerged from the interview data. The solitude self-care actions clustered around two distinct categories: distancing and organizing. The social interaction self-care actions clustered around one category, managing situations. The implications of this study extend to anyone who is in the position of providing care and support to an individual diagnosed as a chronic schizophrenic. Additional research is suggested to increase the generalizability of the findings of this study and to isolate conditions related to Orem's (1985) sets of actions for maintenance of a balance between solitude and social interaction.

Adolescent

Microbiology and potential virulence of Sporothrix cyanescens, a fungus rarely isolated from blood and skin.

Sporothrix cyanescens has been recovered from blood and a finger lesion at several medical centers in the United States. The morphology and physiology of these and three additional isolates were studied. S. cyanescens was distinguished from S. schenckii and S. fungorum by white to lavender colonial pigmentation and from S. schenckii also by the formation of secondary conidia. All isolates of S. cyanescens grew well at 37 degrees C, were cycloheximide susceptible, strongly urease positive, and benomyl resistant, failed to hydrolyze starch, and were inhibited by sodium chloride in vitro at a concentration of greater than or equal to 12%. Study of S. cyanescens in a murine model by using intravenous inoculation failed to demonstrate an invasive pathogenic potential. The validity of the transfer of S. cyanescens to the new genus Cerinosterus Moore is discussed.

Cell Division

Metabolism of monoterpenes: demonstration of the hydroxylation of (+)-sabinene to (+)-cis-sabinol by an enzyme preparation from sage (Salvia officinalis) leaves.

A microsomal preparation from the epidermis of Salvia officinalis leaves catalyzed the NADPH- and O2-dependent hydroxylation of the monoterpene olefin (+)-sabinene to (+)-cis-sabinol. The reaction catalyzed is a key step in the biosynthesis of C3-oxygenated thujane monoterpenes, and the hydroxylase is highly specific for (+)-sabinene as substrate. The hydroxylase from leaf homogenates was solubilized and characterized with regard to reaction conditions, inhibitors, and activators. Activity was partially inhibited by rabbit anti-rat cytochrome P-450 and by CO, and the latter inhibition was reversed by 450 nm light. A CO-difference spectrum and type I substrate binding spectrum were obtained. The hydroxylase meets most of the established criteria for a cytochrome P-450-dependent mixed function oxygenase and represents one of very few enzyme systems of this type to be isolated from leaves of a higher plant.

Bicyclic Monoterpenes

Sensitization and hippocampal type 2 theta in the rat.

Previous research has consistently demonstrated that there are two types of theta which can be recorded from the hippocampus of a variety of species. Type 1 theta occurs during voluntary movements such as walking, running and rearing while type 2 theta occurs during alert immobility. Large amplitude irregular activity (LIA) occurs during more automatic behaviors such as grooming and chewing as well as during non-alert immobility. Type 2 theta can be readily elicited in the unrestrained guinea pig and rabbit. While spontaneous type 2 theta rarely occurs in the rat, short trains of type 2 theta have been observed during conditioning. The purpose of the present study was to examine the relationship between type 2 theta and inescapable shock when the temporal characteristics of the conditioning stimulus (CS) were varied. Three conditioning paradigms (delay, trace, random) were utilized. Type 2 theta production increased over time as a function of the number of shocks and was not due to conditioning. There were no differences in the three groups in the occurrence of type 2 theta during CS presentations or during the inter-stimulus intervals. Previously neutral sensory stimulation also produced type 2 theta after conditioning in all groups. The inescapable shocks placed the rat in a high state of arousal which subsequently sensitized the animal to produce type 2 theta. The data was used to support the hypothesis that a state of arousal is a necessary precursor for the production of type 2 theta.

Acoustic Stimulation

Modified method for fungal slide culture.

A modified slide culture method which combines advantages found in several slide culture methods is described. A block of inoculated nutrient agar sandwiched between two sterile cover glasses is placed in a plastic petri dish containing water agar. After adequate growth has occurred, the slide culture is disassembled and mounted in a conventional manner.

Culture Media

Efforts to improve AME performance through CME and annual performance reports.

Continuing medical education (CME) serves to maintain or increase the knowledge, interpretive proficiencies, and technical skills that a physician uses in his/her practice of medicine. Resulting improvement is frequently difficult to measure, particularly in aerospace medicine, but CME is required for relicensure and/or for medical society membership in 70% of states. The Civil Aeromedical Institute first received American Medical Association approval for Category I CME credit for attendance at FAA seminars in January 1973. We began preparing annual performance reports for each aviation medical examiner (AME) in 1979 to attempt to isolate the causes of, and to reduce, computer rejection of about one-fourth of all medical certification input because of omissions or procedural errors. A special analysis of 1983 AME performance data found that errors were significantly reduced with recent and frequent seminar attendance, larger volume of exams, and pilot and military flight surgeon experience.

Aerospace Medicine

Effect of parasympathetic and beta-adrenergic blockade on the umbilical circulation in the unanesthetized fetal sheep.

Parasympathetic and beta-adrenergic blocking agents were administered to near term chronically instrumented sheep. Parasympathetic blockade resulted in a significant increase in fetal heart rate and fetal arterial blood pressure, with a minimal nonsignificant increase in umbilical blood flow. beta-Adrenergic blockade resulted in a decrease in fetal heart rate and umbilical blood flow, though neither was statistically significant. There was no change in arterial blood pressure. The net result of parasympathetic and beta-adrenergic blockade on fetal heart rate suggests that the intrinsic rate is the same as when these influences are present.

Adrenergic beta-Antagonists

Interdisciplinary health education: a case study of fact and fancy.

Meeting the health needs of patients and providing comphrehensive health care services require the integration and coordination of several professional health services. Traditional methods for training students in the health professions independently are being challenged by the need for future practitioners to understand and to utilize effectively the skills offered by the other disciplines. However, the movement of educational institutions toward interdisciplinary training programs entails the careful assessment of program design, content, and basic philosophy. Two and one-half years of experience with such a program at one academic health center are reviewed.

Adult