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Biomedical subjects

J L Huffman

Publications and source records attributed to J L Huffman.

45 records · Page 3Linked to original sources
PubMed1984

Selective surface staining of bladder tumors by intravesical methylene blue with enhanced endoscopic identification.

Intravesical instillation of methylene blue resulted in selective surface staining of bladder tumors in vivo without staining the background of normal urothelium. Staining of human bladder tumors in vivo was accomplished by the intravesical instillation of 0.1% methylene blue in 0.9% saline through a foley catheter under 20 cm of hydrostatic pressure up to a maximum volume of 400 ml. After 5 minutes contact time, the methylene blue solution was drained, and the bladder was washed with saline. Thereafter, either endoscopic or open surgery was performed. The transitional cell carcinomas in 45 of 48 patients bound methylene blue to the surfaces of the tumors but not to normal urothelium. Higher grade tumors usually bound the dye more extensively than lower grades. The three patients, whose tumors did not bind methylene blue, had received previous chemotherapy, which might account for their being falsely negative. Carcinoma in situ and dysplasia did stain blue. Areas of hyperplasia and cystitis, however, did not bind methylene blue. In vivo intravesical staining with methylene blue has been a simple and safe procedure which has enhanced the endoscopic localization for biopsy and fulguration/resection of transitional cell carcinomas.

Carcinoma in Situ↗
PubMed1984

Ureteroscopy and ureteropyeloscopy.

Transurethral endoscopic access to the upper urinary tract using rigid optics is evolving into a significant addition to the specialty of urology. The basic endoscopic expertise urologists have perfected for use in the urethra, prostate, and bladder is readily transposed to the ureter and renal pelvis. Indications, precautions, instrumentation, and procedural techniques are detailed.

Cystoscopes↗
PubMed1983

Extending cystoscopic techniques into the ureter and renal pelvis. Experience with ureteroscopy and pyeloscopy.

The availability of extended-length, small-caliber endoscopes allows the use of many cystoscopic techniques in the ureter and renal pelvis. Although the instruments are rigid, they can be passed transurethrally in both male and female patients to allow the urologist to diagnose and treat many lesions of the upper urinary tract. The success of our series demonstrates the utility and safety of the technique, which often eliminates the need for surgical exposure of the lesions.

Adult↗
PubMed1983

Atraumatic perforation of bladder. Necessary differential in evaluation of acute condition of abdomen.

Perforation of the urinary bladder without history of antecedent trauma is a rare clinical occurrence. However, in patients with acute conditions of the abdomen, especially those with previous voiding symptoms, the diagnosis should be considered. Three cases are reported. Patients presented with an atraumatic bladder perforation and peritonitis secondary to chronic inflammation, bladder outlet obstruction, and transitional cell carcinoma. After review of the literature, a classification of atraumatic bladder perforation has been revised to include presently available reports of this entity.

Abdomen, Acute↗
PubMed1983

Transurethral removal of large ureteral and renal pelvic calculi using ureteroscopic ultrasonic lithotripsy.

Transurethral ultrasonic fragmentation of stones allows successful endoscopic removal of upper urinary calculi that otherwise would be considered too large to extract. We successfully extracted endoscopically 2 large renal pelvic and 5 large ureteral stones using transurethral ureteropyeloscopy and ultrasonic lithotripsy. The stone is visualized first with the ureteropyeloscope, and then engaged in a basket and either fragmented or disintegrated with the ultrasonic transducer. Any remaining small stone fragments can be retrieved with a stone basket or forceps. There has been little morbidity with this procedure and patients can return to normal activity after discharge from the hospital.

Adult↗
PubMed1983

Combined rigid and flexible ureteropyeloscopy.

The development of rigid and flexible ureteropyeloscopes has provided the means for direct visualization of the upper urinary collecting system. Each instrument has its own advantages and disadvantages. The combined use of these instruments extends the range of endoscopy throughout the intrarenal collecting system, permits irrigation and provides a working channel.

Adult↗
PubMed1983

In vivo urothelial surface histology by microscopic chromocystoscopy.

Microscopic chromocystoscopy is a new in vivo procedure that we have developed to aid in the detection and treatment of bladder tumors. Intravesical ionic dye chromocystoscopy was introduced by our group to permit cystoscopic viewing with ordinary light of selectively stained malignant urothelial surfaces by the cationic dye, methylene blue. With the recent availability of the Hamou hysteroscope, a microscopic endoscope, we have combined intravesical ionic dye chromocystoscopy with microscopic cystoscopy to give in vivo urothelial surface histology, with resolution of cytological detail. We herein describe our new method and preliminary results with this procedure, which we have designated in vivo urothelial surface histology by microscopic chromocystoscopy.

Cystitis↗