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J L Imbs

Publications and source records attributed to J L Imbs.

At least 163 records · Page 9Linked to original sources
PubMed1976

Effects of apomorphine and of pimozide on renin secretion in the anaesthetized dog.

This paper presents the results of a study of the receptors involved in renin hypersecretion induced by dopamine. Apomorphine induces renin hypersecretion without significantly modifying the renal blood flow. This renin hypersecretion is inhibited by haloperidol. However, pimozide, a selective dopaminolytic agent, is incapable of inhibiting the renin hypersecretion induced by dopamine. These results provide supplementary evidence for the existence of renal dopaminergic receptors which would appear to differ from the central dopaminergic receptors.

Animals↗
PubMed1976

[The effects of dl-sotalol on the urinary osmolarity of anesthetized dogs].

The effect of dl-sotalol (intrarenal perfusion of 19 mg/kg during 30 min) on urinary concentration was studied under pentobarbital anaesthesia in dehydrated dogs. Sotalol infusion decreased urinary osmolality and increased natriuresis and urine flow. This diuretic action was accompanied by the reduction of the renin hypersecretion elicited by water deprivation.

Animals↗
PubMed1975

Effect of dopamine on renin secretion in the anesthetized dog.

Intrarenal perfusion of dopamine (6 mug/kg/min for 10 min) caused a significant increase of renin secretion, together with a significant increase in renal blood flow. This renin hypersecretion is not accompanied by any significant alteration in renal perfusion pressure, kalemia or natriuresis. The role of intrarenal dopaminergic receptors has been studied: (a) Haloperidol (intrarenal perfusion of 50 mug/kg/min for 20 min) suppresses the renal vasodilation and renin hypersecretion induced by dopamine. (b) Propranolol (intrarenal perfusion of 1 mg/kg in 15 min, then of 4 mg/kg/hr) alters neither the renal vasodilation nor the renin hypersecretion induced by dopamine. These observations support the assumption that the dopaminergic receptors are brought into play in the two renal responses to dopamine studied by us.

Anesthesia↗
PubMed1975

beta-blocking drugs and renin secretion in the anaesthetized dog.

1. The effect of propranolol and sotalol on renin secretion was studied in the anaesthetized dog. 2. beta-adrenergic blockade did not modify basal renin secretion and did not affect the rise of renin secretion induced by haemorrhage or aortic constriction. 3. beta-adrenergic blockade diminished the rise in renin secretion induced by stimulation of the renal nerves.

Animals↗
PubMed1975

[Effect of d-1 propranolol on urinary osmolarity after furosemide in anesthesized dog].

The effects of propranolol (l mg/kg/H infused in the renal artery) on the diuretic action of furosemide (20 mg/kg i.v.) have been studied in pentobarbital anesthetized dogs. We obtained the 3 following results : the urine remained isotonic to the plasma during the 6 hours following the furosemide injection ; the urinary output of sodium and water, measured during 6 hours after furosemide injection, was increased ; the renin hypersecretion was inhibited.

Animals↗