Effect of hydrocortisone on the synthesis of DNA and histones and the acetylation of histones in regenerating liver.
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Acetates↗
Biomedical subjects
J L Irvin
Publications and source records attributed to J L Irvin.
Purification and characterization of a deoxyribonucleic acid polymerase from rat liver.
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Adenosine Triphosphate↗
Potential anticancer agents. VI. 5-Substituted pyrimidine-6-carboxaldehydes.
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Aldehydes↗
Changes in the physical state of DNA during replication in regenerating liver of the rat.
Evidence is presented which demonstrates that DNA synthesis in regenerating liver is discontinuous. In pulse-labeling experiments from 30 seconds to 10 minutes, the earliest detectable intermediate in DNA replication appears to be double-stranded DNA which has a significant degree of single-stranded character probably due to the existence of gaps in the newly synthesized strand. The label begins to move into completely double-stranded DNA 10-30 minutes after the commencement of labeling. The average molecular weight of the single-stranded "unit" of DNA replication is determined to be approximately 7.5 million. Smaller units may be produced but not observed as a result of imperfect synchronization of DNA synthesis.
Animals↗
Effects of exogenous histones upon the induction of tryptophan pyrrolase and tyrosine transaminase in liver and Morris hepatomas.
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Adrenal Glands↗
Inhibition of thymidine phosphorylation and DNA and histone synthesis in Ehrlich ascites carcinoma.
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Aldehydes↗
Potential anticancer agents. V. The synthesis and biochemical studies of 5-fluorinated pyrimidine-6-carboxaldehydes and derivatives.
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Aldehydes↗
Induction of hepatic tryptophan pyrrolase and tyrosine transaminase by histones and other polypeptides.
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Adrenal Glands↗
Effects of histones on induction of hepatic threonine dehydratase.
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Adrenal Glands↗
Structure and synthesis of 2-(4'-substituted phenyl)-delta1-pyrrolines from 4-phthalimidobutyryl chloride via Friedel-Crafts acylation.
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Benzene Derivatives↗
Inhibiton of calf thymus deoxyribonucleic acid polymerase by histones.
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Adenosine Triphosphate↗
Fluorinated pyrimidine aldehydes. Inhibition of nucleic acid and protein biosynthesis in Ehrlich ascites carcinoma cells in vitro.
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Animals↗
Peptides of pyrimidine amino acids.
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Amino Acids↗
Potential anticancer agents. IV. 5-Substituted pyrimidine-6-carboxaldehydes and derivatives.
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Aldehydes↗
Potential anticancer agents. 3. 2-Phthalimidoaldehydes and derivatives.
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Aldehydes↗
Synthesis and cytotoxicity of 4-aminobutyrophenone hydrochlorides and their substituted pyrimidinylhydrazones.
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Acetophenones↗
Inhibition of DNA polymerase by histones.
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Animals↗
THE BILIARY EXCRETION OF VARIOUS BILE ACIDS BY PATIENTS WITH CHOLEDOCHOSTOMY DRAINAGE, AND THE EFFECT OF ORAL ADMINISTRATION OF DESICCATED BILE OF THE OX AND THE HOG.
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Administration, Oral↗