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J L Lejonc

Publications and source records attributed to J L Lejonc.

At least 55 records · Page 3Linked to original sources
PubMed1980

Nov Presse Med.

Explore the source record for details and available documents.

Acute Kidney Injury↗
PubMed1980

[Paroxystic hypertension after ingestion of gruyere cheese during isoniazide treatment: a report on two cases (author's transl)].

Paroxystic hypertension was observed in two patients receiving isoniazide treatment, after they had ingested gruyere cheese. It is highly probable that isoniazide was responsible, as hypertension did not reoccur under the same conditions after interrupting treatment. One patient developed a vasomotor reaction identical to that which sometimes occurs after the eating of foods rich in tyramine by patients taking monoamine oxydase inhibitors. It could be that in our patients this phenomenon was consecutive to the inhibition of plasma monoamine oxydase by the isoniazide. It was not due to an overdose of isoniazide. This unusual reaction suggest that patients taking isoniazide should be questioned whether they have had post-prandial vasomotor flushes, and if so, advised to avoid foods rich in tyramine.

Adult↗
PubMed1979

Acquired von Willebrand's syndrome with IgM inhibitor against von Willebrand's factor.

This report describes a patient without evident underlying disease, in whom an acquired von Willebrand's syndrome was discovered before surgery. Coagulation abnormalities included a borderline bleeding time, a low retention of platelets on glass beads, decreased levels of factor VIII procoagulant activity (VIIIAHF), factor VIII-related antigen (VIIIAg), and ristocetin-induced agglutination cofactor (VIIIVWF). After cryoprecipitate infusion the patient did not have the expected rise and there was no secondary increment in VIIIAHF. The patient was treated with prednisone for three weeks without significant improvement in the laboratory findings. Spontaneous resolution was observed long after this therapy. The haemostatic abnormalities were attributable to the presence of an inhibitor directed against VIIIVWF. The inhibitor was found in the IgM fraction. Its autoimmune nature is probable although we failed to demonstrate any inhibitory effect of Fab obtained from the patient's purified IgM. Despite the lack of inhibitory effect against VIIIAHF and VIIIAg, the low levels of all three activities of the factor VIII complex could be explained by the short half-life of immune complexes between factor VIII and the inhibitor.

Aged↗
PubMed1976

The cellular distribution of erythrocyte and normoblast A1 and A antigens in normal and preleukemic states. An immunoelectron microscopy study.

A1 and A alloantigens were visualized on human erythrocytes and normoblasts by immunoelectron microscopy using peroxidase-coupled antibodies. Specimens were obtained from patients with preleukemia and associated antigen weakening, and from individuals with normal antigen values. Cells were fixed by glutaraldehyde and subsequently reacted with antibodies.

ABO Blood-Group System↗
PubMed1976

Surface features of cells in human lymphoproliferative disorders. An immunoelectron microscopy study.

Peroxidase conjugated antibodies were applied to cell suspensions in order to detect surface associated immunoglobulins. Cell suspensions were fixed prior to incubation with reagents, a procedure avoiding membrane alterations induced by antibodies to surface component. By immunoelectron microscopy an identification of B lymphocytes could be made with simultaneous observation of their surface architecture. Basic findings were that normal circulating human B lymphocytes had a villous surface. This relationship was not confirmed however by examinating samples from various B and T cell proliferations establishing that surface morphology is not sufficient to categorize cells in disease. Specimens from hairy cell leukemia were also examined. Despite salient surface characteristics as revealed by the present method, the categorization of cells remains unclear.

B-Lymphocytes↗
PubMed1976

[Heterogeneity of the cellular distribution of erythrocytic A antigens. Ultramicroscopic study].

A and A1 antigens have been detected on cells of the human erythrocyte series by immunoelectron microscopy. These antigens have been revealed by an indirect method involving various anti-A and anti-A1 antibodies (allo, auto, hetero-antibodies) and peroxidase-conjugated anti-immunoglobulin antibodies. Immunologic labelling has been carried out with erythrocyte or bone marrow cell suspensions which were fixed prior to incubation with reagents. Cells from various A phenotypes were examined. A and A1 antigens were visualized on maturing normoblasts, at every developmental stage. In addition cell to cell variations of the surface labelling of erythrocytes was found in normal phenotypes, suggesting the existence of several populations of cells according to antigenic load.

ABO Blood-Group System↗
PubMed1976

The heterogeneity of erythrocyte antigen distribution in human normal phenotypes: an immunoelectron microscopy study.

A and A1 antigen were detected on human blood erythrocytes by immunoelectron microscopy using peroxidase-conjugated antibodies. Cells were obtained from various normal A subgroups, including rare weak A phenotypes and infant (cord blood) samples. Erythrocytes were fixed prior to incubation with specific reagents. The detection of surface antigens was carried out by an indirect method involving anti-A and anti-A1 antibodies and conjugated anti-immunoglobulin antibodies. The surface labelling was seen as a diffuse dense layer. Haemperoxidase-like activity resulted in a faint background which did not interfere at the level of ultrathin sections, with surface staining due to exogeneous peroxidase. The most significant finding was the existence, in a given sample, of several populations of cells as revealed by their antibody-binding capacity. The distribution of the various populations varied from one sample to another according to its subgroup. The progressive weakening of phenotype expression which characterizes the various subgroups from A1 to A weak was paralleled by a decreasing number of "antigen rich" cells, which were still detectable in weak phenotypes as a minor population. This study confirms that a given normal phenotype in fact represents a mixture of antigenically different populations of erythrocytes.

ABO Blood-Group System↗
PubMed1975

[Application of the immunoperoxidase method to the study of the membrane of human lymphocytes].

Immunoelectron microscopy was applied to human lymphocytes exposed to purified peroxidase-conjugated anti-immunoglobulin. Indeed, detectable surface immunoglobulins are a salient feature of so-called " B " lymphocytes. On living cells, a rapid and massive internatization of the labelled membrane is observed. Prior glutaraldehyde cell fixation avoids such a phenomenon. Thus, exposure of fixed cells to conjugated anti-immunoglobulin allows the visualization of a dense and continuous specific membrane labelling. Immunoglobulin-bearing lymphocytes have a characteristic membrane surrounded with numerous microvilli. On the other hand, non-labelled lymphocytes have a smooth membrane. Intermediate forms are also noted among these extreme morphological features.

Adult↗