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Biomedical subjects

J L Leroux

Publications and source records attributed to J L Leroux.

At least 55 records · Page 3Linked to original sources
PubMed1988

Rheumatoid nodulosis: report of two new cases and discussion of diagnostic criteria.

Two patients with typical rheumatoid nodulosis are described and compared with 24 reported cases. Rheumatoid nodulosis is a particular variant of rheumatoid arthritis associated with palindromic rheumatism, subcutaneous rheumatoid nodules, mild or no systemic manifestation and a benign clinical course. Positive rheumatoid factor and radiologic subchondral bone cysts are usual, but their absence should not eliminate the diagnosis of rheumatoid nodulosis, particularly at the onset of the disease.

Adult↗
PubMed1983

[Fractures of the calcaneus during fluoride therapy of osteoporosis].

Two cases of calcaneum "stress" fractures are reported. The fracture, which was unilateral in the first case and bilateral in the second, occurred 15 and 18 months respectively after the initiation of fluoride treatment for osteoporosis. The simultaneous discovery of thyrotoxicosis in the second patient suggests that the role of hyperthyroidism in the occurrence of these fractures be discussed in addition to that of fluoride treatment.

Aged↗
PubMed1983

Ultrastructural and crystallographic study of calcifications from a patient with CREST syndrome.

An ultrastructural and crystallographic study was done on calcium deposits obtained from a patient with the CREST syndrome. Optical microscopy showed that large calcific cutaneous deposits seemed to have developed in a dense connective tissue without any inflammatory reaction. The oldest lesions contained heterotopic bone. Electron microscopy showed that calcium deposit, in the slightly mineralized fibers, was located at the center of the elastic fibers. The calcifications were surgically removed and studies were performed on the rough products and, after heating, using x-ray crystallography, differential thermal analysis and quantitative chemical analysis. Our results showed that this cutaneous calcification is a B type carbonated apatite.

Aged↗
PubMed1982

[The hemophilic femoropatellar joint].

The knee is the joint most frequently involved in haemophilia. Femoro-tibial damage in chronic arthropathies has been perfectly described. By contrast, lesions of the patella (with the exception of "squaring") have been reported in only a few scanty publications. An attempt was made to define the characteristics by clinical and radiological study (including in addition to lateral films, an analysis of 30, 60 and 90 degrees axial views, even though these were often made difficult by flexion deformity and joint limitation). Femoro-patellar involvement was seen to be very frequent with various lesions: rarely "squaring", and more often patellar erosions or femoro-patellar incongruence (either pre-existing dysplasia or secondary to haemarthrosis) and sometimes actual incarceration (described as "locked patella" by anglo-saxon authors). These concepts are left to have practical consequences in the management of physiotherapy, synoviorthesis and surgery.

Adolescent↗
PubMed1982

[Rehabilitation and algodystrophies].

Based on 20 years experience, and a personal series of 272 cases of reflex dystrophy (84 cases involving upper limbs, 188 cases involving lower limbs) admitted under a rheumatology unit equipped with all the available techniques of rehabilitative medicine, the authors stress the value of well conducted functional rehabilitation which, even alone, can obtain excellent results in the treatment of this disease, whatever the stage. The authors detail the modalities of this treatment. A local intra-articular or intra-canal injection of corticosteroids permits pain-free physiotherapy. The mobilisation of the lower limb is an urgent priority. Non-aggressive physiotherapeutic techniques should be adapted to the stage and the site of reflex dystrophy. Hydrokinesitherapy and the adaptation of craft techniques to occupational therapy also play an important part.

Exercise Therapy↗
PubMed1981

[Narrow lumbar canal syndrome. Symptomatology and evolutionary aspects].

The authors report a retrospective study of 77 patients with a narrow lumbar canal syndrome (NLC). They recall the semiology, and the clinical and radiological findings which permit one to make the diagnosis and discuss, with an average follow-up of two years, the results of medical treatment (42 cases) or surgical treatment (35 cases), and the management which should be adopted. Medical treatment appears to be indicated in the mild forms of NLC, 34% of patients in this series (functional symptoms reduced and normal neurological examination at rest and after effort) where one may observe 80% of good results. Similarly, medical treatment should be attempted in certain more severe symptomatic forms where are still obtained 26% of good results permitting one to await surgery, and then reserve surgical treatment for failures or relapses. Operation is however definitely indicated in the forms where there are marked neurological signs. Under these conditions, the results of surgery and medical treatment seem comparable and one may note on the whole 60% of good results.

Adult↗
PubMedDate not supplied

Celecoxib is as efficacious as naproxen in the management of acute shoulder pain.

This study compared the analgesic efficacy and safety of the cyclo-oxygenase-2 specific inhibitor celecoxib with the non-specific non-steroidal anti-inflammatory drug, naproxen, in patients with acute shoulder pain. Adult patients with shoulder pain, onset within the previous 14 days and shoulder pain of > or = 40 mm on a 100 mm visual analogue scale (VAS), were treated with oral doses of celecoxib or naproxen for 14 days and followed by a visit at day 42 in a double-blind, randomized study. The primary efficacy assessment was change in maximum pain at rest on a 100 mm VAS at day 14 compared with baseline. In addition, secondary efficacy pain and functional assessments were analysed at baseline, day 14 and day 42. A total of 202 patients were included in the trial (99 celecoxib 400 mg/day; 103 naproxen 1 g/day). The difference in change from baseline at day 14 in maximum pain at rest was not statistically significant between the two treatment groups, but was numerically higher for celecoxib than for naproxen (-47.9 +/- 2.5 versus -42.3 +/- 2.5, respectively). According to the limits of the 95% confidence interval of the difference between groups (-12.52; 1.38), celecoxib appeared to be at least as effective as naproxen. All secondary efficacy measures followed the same pattern, showing similarity between the two treatments with a trend in favour of celecoxib. The incidences of adverse events were similar for both groups. Fewer patients experienced epigastric pain with celecoxib (seven patients versus 14 with naproxen). This adverse event led to discontinuation in two patients receiving celecoxib and five receiving naproxen. Celecoxib 400 mg/day was at least as effective as naproxen 1 g/day in managing pain in this condition.

Acute Disease↗