Biomedical subjects

J L Lozano

Publications and source records attributed to J L Lozano.

22 records · Page 2Linked to original sources

PubMedDate not supplied

[Verrucous carcinoma of the penis. Presentation of 3 new cases].

Penis carcinoma shows an incidence between 0.3-1% of all male neoplasias. The verruciform variety represents 5-10% of total penis carcinoma. Verruciform carcinoma is a variety of squamous carcinoma presenting a usually benign behaviour and related to some virus species (H.P.V.). Three cases are presented with ages ranging between 47-87 years-old, all of which undergoing partial penectomy, their progression being monitored for two years.

Aged↗

PubMedDate not supplied

[Cavernous angioma of the testis. Presentation of a new case].

We present a fresh case of testicular angioma in a 15-year-old patient. The symptomatology displayed, along with the scrotal echograph, made us suspect the existence of testicular tumoration, which led us to carry out surgical exploration. After orchiectomy, it is Pathological Anatomy that provides us with the final diagnosis. We comment on the different histological patterns and make a review of the literature.

Adolescent↗

PubMedDate not supplied

Role of prostaglandins on lymphocyte transformation in Crohn's disease.

We analyzed the response to phytohemagglutinin (PHA) of peripheral blood (PBL), intraepithelial (IEL) and lamina propia (LPL) lymphocytes in eight patients with Crohn's disease (CD). We also studied the effect of indomethacin, a prostaglandin synthetase inhibitor, and monocyte depletion on mitogen-induced stimulation of these cells. The blastic stimulation index was significantly lower in PBL and intestinal mucosa lymphocytes of CD than in controls (p less than 0.001). This index increased after addition of indomethacin in PBL and LPL and after monocyte depletion in PBL. The suppressor index on blastic stimulation, obtained when indomethacin had been added to the cultures was higher in PBL and intestinal mucosa lymphocytes of patients with CD than in controls. After monocyte depletion, this suppressor index decreased significantly in PBL and did not change in controls. These data suggest that prostaglandins could be one of the responsible factors for hyporesponsiveness of lymphocytes in CD.

Adult↗

PubMedDate not supplied

Intestinal and peripheral blood lymphocyte subpopulations in Crohn's disease.

Cellular immunity has been implicated in the pathogenesis of Crohn's disease. In the present work, we have studied T-lymphocytes subsets in peripheral blood and intestinal mucosa of eight patients with active disease, using monoclonal antibodies. Intraepithelial and lamina propia OKT-3 +ve cells were significantly lower than in peripheral blood (p less than 0.001). We have found an increase of B cells and OKT-8 +ve cells in intestinal mucosa with a significant decrease in helper/suppressor ratio. These findings are in accordance with a high suppressor-cytotoxic function in patients with active diseases.

Adolescent↗