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Biomedical subjects

J L Módena

Publications and source records attributed to J L Módena.

15 recordsLinked to original sources
PubMed1986

Simple suture with or without proximal gastric vagotomy for perforated duodenal ulcer.

To assess the results of proximal gastric vagotomy (PGV) in the definitive treatment of perforated duodenal ulcers, a prospective study was carried out comparing PGV in association with omental patch suture (PGV + S) with the simple omental patch suture procedure (S). The PGV + S series consisted of 38 consecutive patients with perforated duodenal ulcer and the S series consisted of 38 survivors of a similar series of 41 consecutive patients. Surgical mortality was zero in the PGV + S series. The patients were followed up for 1 to 7 years. No cases of dumping or diarrhoea were observed. Thirty-three patients in the PGV + S series (87 per cent) were classified as Visick grade I and only two (5 per cent) as Visick grade IV. In contrast, 11 patients (29 per cent) were Visick grade I and 22 (58 per cent) were Visick grade IV in the S series. Recurrent ulcer was detected endoscopically in 58 per cent of the patients who had been treated with simple suture and in only 5 per cent after suture plus PGV. PGV is a safe operation with a negligible morbidity rate and with a significant rate of effective control of ulcer disease. Depending on the general condition of the patient and on the surgeon's skill, it appears preferable to treat not only the acute perforation but also the ulcer disease by PGV.

Adult↗
PubMed1972

[Gastric syphilis].

Explore the source record for details and available documents.

Diagnosis, Differential↗
PubMedDate not supplied

[Gastric paracoccidioidomycosis. A case report and considerations on the pathogenesis of this disease].

The authors report an unusual case of fungal gastric lesion in a patient with the chronic form of paracoccidioidomycosis. For a period of 8 months the major symptoms of the patient were abdominal pain and body weight loss. The endoscopic evaluation of the upper gastrointestinal tract showed a partial gastrectomy made previously, a great and irregular ulcer in the stomach and a granulated aspect of the duodenal mucosa. A granulomatous process and Paracoccidioides brasiliensis were observed in the histopathological examination of the gastric and duodenal biopsy tissue. New endoscopic evaluation 4 months after treatment with sulfadiazine revealed healing of the gastric ulcer. It was suggested that abdominal lymph nodes involvement, duodenal infection and anatomical and atrophic alterations of the stomach were predisposing factors for the gastric paracoccidioidomycosis.

Chronic Disease↗
PubMedDate not supplied

[Tissue levels of 6-ketoprostaglandin Fl alpha and integrity of gastric mucosa in patients with Chagas disease].

An increased prevalence of chronic gastritis has been reported in patients with chronic Chagas' disease (American trypanosomiasis), which is regarded to be model of intrinsic denervation of the gastrointestinal tract. In order to investigate whether this condition is associated with a reduction of prostaglandin levels in gastric mucosa, we studied 14 Chagas' disease patients with megaesophagus and/or megacolon and compared them with 10 control subjects. All patients and controls underwent an upper gastrointestinal tract endoscopy where biopsies were collected from the antrum for histology and for 6-keto-PGF 1 alpha radioimmunoassay. In the Chagas' disease group, the proportion of patients with either moderate or severe gastritis (7/14) was significantly higher (p < 0.01) than in the control group (0/10). Values for antral 6-keto-PGF 1 alpha in Chagas' disease patients (median: 80.75 ng/g; range 36.5-245.6 ng/g) were slightly lower than those obtained in controls (median: 116.2 ng/g; range: 13.1-269 ng/g), but the difference was not statistically significant (p > 0.10). These results confirm previous observations suggestive of an increased prevalence of chronic gastritis in Chagas' disease, but do not support the view that chronic destruction of the intramural neurons of the gut, which is known to occur in this condition, is associated with a reduction of prostaglandin levels in gastric antral mucosa.

6-Ketoprostaglandin F1 alpha↗
PubMedDate not supplied

Immediate effects of the endoscopic sphincterotomy on the motility of the sphincter of Oddi.

An endoscopic manometric technique was used to determine the CBD-duodenum junction pressure profile before and immediately after endoscopic sphincterotomy in 13 patients with common bile duct stones. Premedication (meperidine, atropine, and diazepam) was given to all patients and endoscopic retrograde cholangiopancreatography was performed before endoscopic sphincterotomy. In the patients with intact papilla the features of the sphincter of Oddi motility were similar to those previously described for patients not given premedication or submitted to cholangiography before endoscopic sphincterotomy. Endoscopic sphincterotomy which was successful for immediate stone removal in 9 of 13 patients caused an immediate reduction of sphincter of Oddi motility in all patients, but abolished it in only 2 of them. The present results show that successful common bile duct stone extraction by means of endoscopic sphincterotomy can be accomplished without total abolition of sphincter of Oddi motility.

Aged↗
PubMedDate not supplied

[Endoscopic evaluation of the involvement of the esophagus, stomach and duodenum in human paracoccidioidomycosis].

The upper gastrointestinal tract was investigated endoscopically in 30 patients with paracoccidioidomycosis. Esophagus, stomach and duodenum showed, respectivelly, 40%, 53% and 43% of endoscopic alterations. The histopathological examination of biopsy tissue revealed no specific lesions in esophagus and stomach, but P. brasiliensis was observed in three cases of duodenal lesions: two cases with mucosal diffuse erosions and one case of duodenal polyp. It is concluded that duodenal paracoccidioidomycosis is not rare and could be revealed by endoscopic examination in patients with disseminated disease.

Adolescent↗