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J L Martín-Lorente

Publications and source records attributed to J L Martín-Lorente.

7 recordsLinked to original sources
PubMed2006

[Microhematuria secondary to mucocele and appendicular cystoadenoma].

Appendiceal mucocele is a rare entity consisting of cystic dilatation of the appendix as a result of increased mucus production. Most cases are related to the presence of a cystadenoma. This appendiceal neoplasm is frequently associated with other extraintestinal and colonic tumors and therefore adequate abdominal examination is necessary. The clinical presentation is nonspecific and varies from asymptomatic forms to abdominal discomfort and, less frequently, to urological manifestations. We describe the case of a woman with hematuria associated with an appendiceal mucocele. Only a few cases have been reported in the medical literature. The treatment of choice of cystadenoma is surgery and simple mucocele cannot be macroscopically differentiated from cystadenoma and cystadenocarcinoma. Survival in patients with appendiceal cystadenoma is excellent. The 5-year survival rate is reduced by at least half in patients with cystadenocarcinoma associated with pseudomyxoma peritonei.

Appendiceal Neoplasms↗
PubMed2003

[Ulcerative colitis associated with idiopathic thrombocytopenic purpura].

Multiple hematological anomalies have been described in association with chronic inflammatory bowel disease. Idiopathic thrombocytopenic purpura is an autoimmune disease characterized by the presence of isolated thrombopenia with a normal or increased number of megakaryocytes in bone marrow and absence of splenomegaly. Several case reports of idiopathic thrombocytopenic purpura associated with chronic inflammatory bowel disease, mostly ulcerative colitis, have been published in the literature. The pathogenic mechanism through which these entities are associated is unknown. Several treatments have been used, varying from short courses of steroids to the use of immunosuppressive agents and splenectomy, depending on the severity of the symptoms. We describe the case of a woman with ulcerative colitis and idiopathic thrombocytopenic purpura, in which the latter first presented when the patient was undergoing treatment with corticosteroids and cyclosporin, one of the therapeutic options for controlling thrombopenic purpura. Platelet deficiency persisted despite treatment with azathioprine and colectomy, also described as a possible curative treatment.

Adult↗
PubMed1998

Influence of the transmission route and disease duration in the histopathology of chronic hepatitis C: a study of 101 patients.

OBJECTIVE: Different studies have demonstrated that factors such as transmission route, disease duration and age at the time of infection can influence the histological evolution of chronic hepatitis by the hepatitis C virus (HCV). The aim of this study was to determine if epidemiological factors such as disease duration and transmission route influence the severity of the histological lesions of patients with chronic hepatitis by HCV. DESIGN: A prospective study. METHODS: The hepatic biopsies of 101 patients diagnosed with chronic hepatitis by HCV were studied. The patients were divided into three groups according to transmission mode: (1) post-transfusional (n = 28), (2) associated with the use of drugs by parenteral route or intravenous drug use (n = 28), and (3) sporadic hepatitis (n = 45). RESULTS: We found more severe forms of hepatopathy in post-transfusional hepatitis and sporadic groups than in the intravenous drug user group of patients. The disease evolution time was significantly higher in patients diagnosed as having chronic active hepatitis with or without cirrhosis (13.8 +/- 9 years) than in patients with chronic persistent hepatitis (8 +/- 4 years), P < 0.01. We found a significant correlation between the evolution time of the infection by HCV and the Histology Activity Index (P < 0.01). The multivariate analysis showed that only the transmission route and the disease evolution time are predictive variables of Histology Activity Index in chronic hepatitis C. CONCLUSION: These results suggest that the post-transfusional and sporadic transmission routes and a greater evolution time of the disease are epidemiological variables that are associated with the presence of more severe histological lesions in chronic hepatitis C.

Adolescent↗