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Biomedical subjects

J L Marti-Vilalta

Publications and source records attributed to J L Marti-Vilalta.

9 recordsLinked to original sources

[Carotid thrombus and cerebral infarction as the initial clinical manifestation of polycythemia vera].

Polycythemia vera (PV) can produce cerebral infarction. The mechanisms proposed by most authors are hyperviscosity-related diminished cerebral blood flow and platelet function abnormalities. We present a 36-year-old woman whose initial clinical manifestation of PV consisted of cerebral ischemia due to a carotid thrombus, as well as occlusion of the middle cerebral artery and cortical branches of the anterior cerebral artery demonstrated by angiography. To our knowledge, this is the first published case of cerebral infarction in PV caused by a thrombus of an extracranial artery. Therefore, PV can produce ischemic stroke due to thrombosis not only in small distal arteries or arterioles but also in the carotid artery or main branches. Treatment of intraluminal thrombus in non-arteriosclerotic carotid artery is discussed. Myeloproliferative disorders, including PV, must be suspected in all stroke patients with an elevated platelet count, even in those who have potential causes of reactive thrombocytosis.

Adult↗

[Lobar cerebral hemorrhage. Clinical aspects, etiology and course. Review of 58 cases].

Fifty eight patients with spontaneous lobar hemorrhage of a 264 patients series with intracerebral hemorrhage seen during a six years period are reviewed. Twenty nine had arterial hypertension, 9 had other etiologies, and in the remaining 20 cases no apparent etiology was detected. Headache was a prominent symptom and occurred in 56%. Seizures occurred in 12%. Coma was infrequent. Clinical findings on admission depended on the location of the hematoma. Lobar hemorrhage occurred most commonly in the parietal region. Mortality rate was 8.6%. Size of hematoma (larger than 4 cm) on CT and altered consciousness on admission correlated with poor outcome.

Adult↗

Leuko-araiosis on magnetic resonance imaging and speed of mental processing.

The clinical significance of white matter abnormalities seen in brain imaging studies, termed leuko-araiosis (LA), still remains uncertain. Leuko-araiosis has been associated with a global decline in cognitive performance, although little is known about the cognitive functions that LA may account for. We present the correlates between LA severity on magnetic resonance imaging and mental deterioration in a selected sample of 41 elderly patients with vascular risk factors. We found that LA was related to performance on tasks measuring the speed of information processing and, in particular, on those that involve complex processes. This impairment can be important in producing reduction in daily living activities as it is in the support to the relationship found with some commonly used behavioral rating scales. Leuko-araiosis is also related to the presence of some primitive reflexes, suggesting that their disinhibition may be due to diffuse corticofugal fibers damage.

Aged↗

The palmomental reflex. Clinical study of 300 cases.

In 300 subjects divided into three equal series of healthy adults, healthy newborn children and adults with neurological diseases, a clinical study of the palmomental reflex (PMR) is carried out, showing its methodology for the examination and appraisal of the reflex response. The PMR appears in 11% of the healthy adults, in 25% of the healthy newborn children and in 72% of the adults with neurological diseases. Habituation to the reflex response is significantly different in the three series, and this is the most important data to consider whether the PMR is physiological or pathological. No significant difference was objectified on evoking the reflex response by stimulation of the thenar region or the thumb.

Adult↗

Thalamic hemorrhage. A study of 23 patients with diagnosis by computed tomography.

A series of 23 patients with thalamic hemorrhage with computed tomography confirmation is reported. Nine of these died, all had hematomas larger than 3.3 cm. The value of the syndrome of downward and convergent ocular deviation is stressed, and its possible mechanisms are analyzed. The characteristics and mechanisms of the pupillary abnormalities are reported, as well as the speech abnormalities observed in patients with lesions of the dominant hemisphere. Prognostic conclusions are drawn.

Adult↗