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Biomedical subjects

J L Mas

Publications and source records attributed to J L Mas.

At least 109 records · Page 6Linked to original sources
PubMed1988

Prevalence of patent foramen ovale in patients with stroke.

The cause of ischemic stroke in younger adults is undefined in as many as 35 percent of patients. We studied the prevalence of patent foramen ovale as detected by contrast echocardiography in a population of 60 adults under 55 years old with ischemic stroke and a normal cardiac examination. We compared the results with those in a control group of 100 patients. The prevalence of patent foramen ovale was significantly higher in the patients with stroke (40 percent) than in the control group (10 percent, P less than 0.001). Among the patients with stroke, the prevalence of patent foramen ovale was 21 percent in 19 patients with an identifiable cause of their stroke, 40 percent in 15 patients with no identifiable cause but a risk factor for stroke, such as mitral valve prolapse, migraine, or use of contraceptive agents, and 54 percent in 26 patients with no identifiable cause (P less than 0.10). These results suggest that because of the high prevalence of clinically latent venous thrombosis, paradoxical embolism through a patent foramen ovale may be responsible for stroke more often than is usually suspected.

Adult↗
PubMed1988

Duplex scanning in extracranial vertebral artery dissection.

Ultrasonic (duplex scanning and continuous-wave Doppler) and angiographic findings in three patients with bilateral extracranial vertebral artery dissection are reported. A pattern of ultrasonic anomalies diagnostic of dissection is described, including association of a localized increase in diameter of the artery with hemodynamic signs of stenosis or occlusion at the same level and decreased pulsatility and presence of intravascular echoes in the enlarged segment.

Adult↗
PubMed1987

Prevalence of asymptomatic internal carotid artery stenosis.

The prevalence of internal carotid artery stenosis was studied with continuous wave Doppler and Duplex scanning in 526 subjects aged 45-84 years of age. They were devoid of any cerebrovascular symptoms or signs and were not referred to us because of risk factors or manifestations of atherosclerosis. The prevalence of stenosis, whatever the grade, was low in both sexes aged under 65 years: 2.4% in males aged 55-64 years. It increased sharply with age, reaching 30.3% for stenosis of less than 50% and 6.1% for stenosis of greater than 50% in males aged 75-84 years. The prevalence of minimal lesion (plaque with less than 15% diameter reduction) was high: 32.1% in males aged 45-54 years and 48.5% in the 75- to 84-year age range.

Aged↗
PubMed1987

[Epidemiology of Alzheimer's type dementia].

Although still fragmentary, currently available epidemiologic data allow an analysis of the magnitude of the problem raised by Alzheimer type dementia. Its prevalence after 65 years of age varies between 1 and 5.8 p. 100, increasing markedly with advancing age to reach, from about 0.1 p. 100 between 55 and 65 years, 1 p. 100 between 65 and 74 and 10 p. 100 beyond 85 years. Based on these data it can be estimated that there are presently about 300,000 patients 60 years of age or over with Alzheimer type dementia (ATD) in France. The only risk factor for ATD identified at the present time is age but a family history of dementia could constitute a further risk factor for the disease. Progress in the field of epidemiology of ATD requires the development and validation of diagnostic criteria and standardized measuring instruments, allowing comparison of results of studies conducted by different teams in different countries, nearly impossible up to the present.

Aged↗
PubMed1987

[Dissecting aneurysm of the extracranial vertebral arteries and pregnancy].

A 32-year-old woman was at the end of her first and-until then normal-pregnancy, when she abruptly experienced a severe neck pain. Delivery was provoked two days later but a week after she suddenly developed a left lateral medullary syndrome. Angiography disclosed a severe diffuse and irregular narrowing of both vertebral arteries in their second and third segments, typical of dissecting aneurysm. The patient was treated with heparin and made a partial recovery. A second angiography nine months later showed a normal left vertebral artery while the right one was probably occluded.

Adult↗
PubMed1986

Mortality from stroke in France 1968-1982.

Mortality data collected from 1968 to 1982 were screened in order to identify all death certificates listing stroke as underlying cause of death. Annual age- and sex-specific death rates were calculated using population data obtained from the 1968, 1975 and 1982 census of the French population. Data showed that stroke mortality has been declining by more than 30%, in most age groups both in men and women. There was a slight trend for this decline to be greater between 50 and 75 years of age in both sexes. A small increase was observed in women under 40 years of age. Large and stable variations in stroke mortality were found within France.

Adult↗
PubMed1985

Chorea and polycythaemia.

Two patients with chorea and polycythaemia vera are described. The literature on this rare association is reviewed and its pathophysiology discussed.

Aged↗
PubMed1985

Hyperlipidemic dementia.

The dementia of a patient with hyperlipidemia improved dramatically on treatment with diet and fenofibrate. Rheologic study showed an abnormality of rouleaux disaggregation, and this disappeared as plasma lipid levels fell and mental state improved.

Clofibrate↗
PubMed1984

[Central nervous system involvement in systemic lupus erythematosus].

Three cases are presented, in two of which the CNS lesions revealed the presence of systemic lupus erythematosus (SLE). The diagnosis of SLE was certain according to the criteria of the ARA, and it was further confirmed by results of renal needle puncture biopsy. Case 1: A 16-year-old adolescent developed choreic movements followed, one month later, by psychotic symptoms suggesting a mixed hebephrenic-catatonic schizophrenic affection. Cutaneous lesions and signs of renal insufficiency 3 months later established that these disorders were related to SLE. A favourable outcome was observed rapidly for the systemic signs, recovery from neuropsychic symptoms being obtained after 3 months only but then in a few days. This course suggests the diagnosis of a "functional psychosis" of lupus origin. Case 2: A 24-year-old woman developed left hemiparesis followed by febrile coma. The slowly favourable course of the disease led to the appearance of a progressive dementia, with numerous epileptic seizures. Although tests for antinuclear antibodies were negative and the ESR was normal, several minor biological anomalies were suggestive of a systemic disease and the diagnosis of SLE was finally established. Corticotherapy produced only slight transient improvement. This progression towards dementia with progressive cerebral atrophy is most probably related to cerebral lupus lesions, the initial coma in the absence of any other apparent cause possibly being the first sign. Case 3: A 47-year-old woman developed simultaneously or separately episodes of arthralgia and uveitis of unknown origin over a 12-year period, and attacks of regressive multilocular neurological deficiency over a 15-year period.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗