Biomedical subjects

J L Mastboom

Publications and source records attributed to J L Mastboom.

13 recordsLinked to original sources

PubMed1985

Absorption of 17 beta-estradiol in a neovagina constructed from the peritoneum.

Estrogen absorption from the neovagina was studied by administering 2.0 mg of micronized 17 beta-estradiol (E2) neovaginally to 6 patients. The neovagina in each patient was constructed by using the peritoneum from the pouch of Douglas. A mean peak of circulating E2 concentrations more than 15-times the basal level was achieved 90 min after the application. Until 12.5 h after the application, the E2 levels were significantly (P less than 10(-6)) elevated. FSH levels were significantly (P = 0.003) changed in comparison to the basal serum concentration. There was no significant (P = 0.08) change in LH levels. The resorption of estradiol from the neovagina is similar to that seen in women with normal vaginas.

Administration, Topical↗

PubMed1982

Artificial vaginas: possible sources of epithelialization.

Biopsy specimens from surgically created peritoneium-lined vaginas in 23 patients with complete vaginal agenesis showed squamous metaplastic epithelium lining the vaginal canal. In nine of the patients, histologic or cytologic evidence, or both, suggested that the metaplastic squamous epithelium could be derived from pre-existing glandular epithelium - sebaceous, paramesonephric (mullerian), or urogenital sinus. The histologic and cytologic features in six patients with paramesonephric-like gland elements in the mucosa and submucosa of the neovagina were similar to the features seen in milder forms of vaginal adenosis.

Biopsy↗

PubMed1977

Restriction on the indications for metroplasty.

When a congenital uterine anomaly has been diagnosed, surgical correction of the malformed uterus is usually carried out. However, minor disturbances of glucose metabolism are easily overlooked in the presence of major congenital uterine malformation. In this paper we studied the obstetrical histories of 76 patients with congenital uterine anomalies. In the group with repeated pregnancy failure we found significantly more disturbances in carbohydrate metabolism than in the group with uneventful pregnancies (P less than 0.001). Treatment of any disturbances of carbohydrate metabolism greatly improves the fetal outcome. This suggests that such treatment is essential in the management of patients with a bad obstetrical history and may even make surgical correction unnecessary.

Abortion, Habitual↗

PubMed1973